Checkpoint kinase 1 in DNA damage response and cell cycle regulation
Open accessAbstract
Originally identified as a mediator of DNA damage response (DDR), checkpoint kinase 1 (Chk1) has a broader role in checkpoint activation in DDR and normal cell cycle regulation. Chk1 activation involves phosphorylation at conserved sites. However, recent work has identified a splice variant of Chk1, which may regulate Chk1 in both DDR and normal cell cycle via molecular interaction. Upon activation, Chk1 phosphorylates a variety of substrate proteins, resulting in the activation of DNA damage checkpoints, cell cycle arrest, DNA repair, and/or cell death. Chk1 and its related signaling may be an effective therapeutic target in diseases such as cancer.
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Active Chk1 phosphorylates Rad51, a protein involved in homologous recombination repair of double-strand breaks.
“activated Chk1 phosphorylates its own substrates such as protein Rad51, which is involved in the DSB repair by HR [193–195]”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [193]
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References 103 · Cited by 317
- Authors
- Patil, M., Pabla, N., & Dong, Z.
- Affiliations
- Augusta University (US)
- St. Jude Children's Research Hospital (US)
- Central South University (CN)
- Corresponding author
- Dong, Zheng
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2013-03-19
- Volume
- 70
- Issue
- 21
- Pages
- 4009-4021
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC3731415
- OpenAlex
- W2011923111
- Cited by
- 317
- References
- 103
- Citations by year
- 2026: 24 · 2025: 35 · 2024: 28 · 2023: 24 · 2022: 27 · 2021: 44 · 2020: 38 · 2019: 24 · 2018: 20 · 2017: 17 · 2016: 14 · 2015: 12 · 2014: 9 · 2013: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX000319)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK087843, R01DK058831)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- Chk1, DNA damage response, cell cycle regulation, DNA damage checkpoint, cell cycle arrest, DNA repair, cell death, Chk1 phosphorylation, therapeutic target, cancer
- MeSH terms
- Checkpoint Kinase 1, Amino Acid Sequence, Animals, DNA Damage, DNA Repair, Humans, Molecular Sequence Data, Neoplasms, Phosphorylation, Protein Binding, Protein Kinases, Species Specificity, Signal Transduction, Sequence Homology, Amino Acid, Cell Cycle Checkpoints
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