The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
MITF in melanoma: mechanisms behind its expression and activity
Open accessAbstract
MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-specific transcription factor whose role is profoundly extended in malignant melanoma. Over the last few years, the function of MITF has been tightly connected to plasticity of melanoma cells. MITF participates in executing diverse melanoma phenotypes defined by distinct gene expression profiles. Mutation-dependent alterations in MITF expression and activity have been found in a relatively small subset of melanomas. MITF activity is rather modulated by its upstream activators and suppressors operating on transcriptional, post-transcriptional and post-translational levels. These regulatory mechanisms also include epigenetic and microenvironmental signals. Several transcription factors and signaling pathways involved in the regulation of MITF expression and/or activity such as the Wnt/β-catenin pathway are broadly utilized by various types of tumors, whereas others, e.g., BRAF(V600E)/ERK1/2 are more specific for melanoma. Furthermore, the MITF activity can be affected by the availability of transcriptional co-partners that are often redirected by MITF from their own canonical signaling pathways. In this review, we discuss the complexity of a multilevel regulation of MITF expression and activity that underlies distinct context-related phenotypes of melanoma and might explain diverse responses of melanoma patients to currently used therapeutics.
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MITF: master regulator of melanocyte development and melanoma oncogene
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The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma
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Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
Haq, R., Shoag, J., Andreu-Perez, P., Yokoyama, S., Edelman, H., Rowe, G. C., Frederick, D. T., Hurley, A. D., Nellore, A., Kung, A. L., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.003 · Cited by 818
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Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene
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Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
Carreira, S., Goodall, J., Denat, L., Rodriguez, M., Nuciforo, P., Hoek, K. S., Testori, A., Larue, L., & Goding, C. R. (2006) · Genes & Development · doi:10.1101/gad.406406 · Cited by 608
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Aibar, S., González-Blas, C. B., Moerman, T., Huynh-Thu, V. A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.-C., Geurts, P., Aerts, J., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4463 · Cited by 6,520
Bai, X., Fisher, D. E., & Flaherty, K. T. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0204-6 · Cited by 107
TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF
Seberg, H. E., Van Otterloo, E., Loftus, S. K., Liu, H., Bonde, G., Sompallae, R., Gildea, D. E., Santana, J. F., Manak, J. R., Pavan, W. J., et al. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006636 · Cited by 85
Selective Wnt/β-catenin Small-molecule Inhibitor CWP232228 Impairs Tumor Growth of Colon Cancer
KIM, J. Y., PARK, G., KRISHNAN, M., HA, E., & CHUN, K.-S. (2019) · Anticancer Research · doi:10.21873/anticanres.13514 · Cited by 18
Seo, J., Jeong, C., Oh, S., Lee, S.-Y., Park, H., Seo, D., Yoo, D., Sim, W.-J., Lim, T.-G., Park, J. H. Y., et al. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5454 · Cited by 6
Metadata
- Authors
- Hartman, M. L., & Czyz, M.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2014-11-30
- Volume
- 72
- Issue
- 7
- Pages
- 1249-1260
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W2075240818
- Cited by
- 320
- References
- 139
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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