Proteogenomics: emergence and promise
Open accessAbstract
Proteogenomics, or the integration of proteomics with genomics and transcriptomics, is emerging as the next step towards a unified understanding of cellular functions. Looking globally and simultaneously at gene structure, RNA expression, protein synthesis and post-translational modifications have become technically feasible and offer a new perspective to molecular processes. Recent publications have highlighted the value of proteogenomics in oncology for defining the molecular signature of human tumors, and translation to other areas of biomedicine and life sciences is anticipated. This mini-review will discuss recent developments, challenges and perspectives in proteogenomics.
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References 24 · Cited by 36
- Authors
- Faulkner, S., Dun, M. D., & Hondermarck, H.
- Affiliations
- Hunter Medical Research Institute (AU)
- Corresponding author
- Hondermarck, Hubert
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2015-01-22
- Volume
- 72
- Issue
- 5
- Pages
- 953-957
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11113406
- OpenAlex
- W2091921928
- Cited by
- 36
- References
- 24
- Citations by year
- 2023: 4 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 5
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Funders
- Hunter Cancer Research Alliance
- University of Newcastle Australia
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- proteogenomics, proteomics, genomics, transcriptomics, post-translational modification, gene structure, RNA expression, protein synthesis, tumor molecular signatures
- MeSH terms
- Humans, Neoplasms, Proteins, RNA, Messenger, Genomics, Proteomics, Metabolomics
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