The DOI matches its Crossref record; 273 of the 273 references it cites were found in a registry or an index.
The role of the prolactin/vasoinhibin axis in rheumatoid arthritis: an integrative overview
Open accessAbstract
Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease destroying articular cartilage and bone. The female preponderance and the influence of reproductive states in RA have long linked this disease to sexually dimorphic, reproductive hormones such as prolactin (PRL). PRL has immune-enhancing properties and increases in the circulation of some patients with RA. However, PRL also suppresses the immune system, stimulates the formation and survival of joint tissues, acquires antiangiogenic properties upon its cleavage to vasoinhibins, and protects against joint destruction and inflammation in the adjuvant-induced model of RA. This review addresses risk factors for RA linked to PRL, the effects of PRL and vasoinhibins on joint tissues, blood vessels, and immune cells, and the clinical and experimental data associating PRL with RA. This information provides important insights into the pathophysiology of RA and highlights protective actions of the PRL/vasoinhibin axis that could lead to therapeutic benefits.
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“Other inflammation-related genes dysregulated in hEDS/HSD include SPON2, up-regulated in patients’ cells, which encodes an ECM protein with multifunctional properties in the innate immune system and inflammatory cell recruitment [152,153,154], and PRLR, showing a decreased expression in hEDS/HSD cells, which encode the prolactin receptor implicated in inflammatory responses and immune cells”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [155]
In the citing paper
“Other inflammation-related genes dysregulated in hEDS/HSD include SPON2, up-regulated in patients’ cells, which encodes an ECM protein with multifunctional properties in the innate immune system and inflammatory cell recruitment [152,153,154], and PRLR, showing a decreased expression in hEDS/HSD cells, which encode the prolactin receptor implicated in inflammatory responses and immune cells”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [155]
Citations
Cites
Items 201–273 of 273
Stress in Autoimmune Disease Models
Harbuz, M. S., Richards, L. J., Chover-González, A. J., Martı́, O., & Jessop, D. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1351.005 · Cited by 37
Raised serum prolactin in rheumatoid arthritis: genuine or laboratory artefact?
Ram, S. (2004) · British journal of rheumatology · doi:10.1093/rheumatology/keh307 · Cited by 37
Insight into the mechanism by which metoclopramide improves immune functions after trauma-hemorrhage
Knöferl, M. W., Angele, M. K., Ayala, A., Cioffi, W. G., Bland, K. I., & Chaudry, I. H. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.1.c72 · Cited by 36
Bu, G., Wang, C. Y., Cai, G., Leung, F. C.-C., Xu, M., Wang, H., Huang, G., Li, J., & Wang, Y. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.001 · Cited by 36
Prolactin Treatment Improves Engraftment and Function of Transplanted Pancreatic Islets
Johansson, M., Olerud, J., Jansson, L. E., & Carlsson, P. (2008) · Endocrinology · doi:10.1210/en.2008-1318 · Cited by 36
Angiogenesis as a Therapeutic Target in Arthritis: Lessons from Oncology
Bainbridge, J., Sivakumar, B., & Paleolog, E. M. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777698747 · Cited by 36
Antiangiogenesis for Rheumatoid Arthritis
Roccaro, A. M., Russo, F., Cirulli, T., Pietro, G., Vacca, A., & Dammacco, F. (2005) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010053622911 · Cited by 36
Prolactin as an immunoreactive agent
Drača, S. (1995) · Immunology and Cell Biology · doi:10.1038/icb.1995.77 · Cited by 36
Prolactin and prolactin-like polypeptides in rheumatoid arthritis
Neidhart, M., Gay, R. E., & Gay, S. (1999) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(99)80091-2 · Cited by 35
Marcenaro, M., Prete, C., Badini, A., SULLI, L., MAGI, E., & Cutolo, M. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07666.x · Cited by 34
Lotinun, S., Limlomwongse, L., Sirikulchayanonta, V., & Krishnamra, N. (2003) · Endocrine · doi:10.1385/endo:20:1-2:163 · Cited by 34
Prolactin modulates survival and cellular immune functions in septic mice
Oberbeck, R., Schmitz, D., Wilsenack, K., Schuler, M. H. H., Biskup, C., Schedlowski, M., Nast-Kolb, D. C., & Exton, M. S. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00214-2 · Cited by 33
Spector, T. D., & Hochberg, M. C. (1989) · Lara D. Veeken · doi:10.1093/rheumatology/xxviii.suppl_1.11 · Cited by 32
Bromocriptine induces immunological changes related to disease parameters in rheumatoid arthritis
Figueroa, F. E., Carrión, F., Martinez, M. E., Rivero, S., & Mamani, I. L. (1997) · Lara D. Veeken · doi:10.1093/rheumatology/36.9.1022 · Cited by 32
Krishnamra, N., & SEEMOUNG, J. (1996) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-74-10-1157 · Cited by 32
Gender differences and protective effects of testosterone in collagen induced arthritis in rats
Ganesan, K., Selvam, R., Abhirami, R., Raju, K. N. N., Manohar, B. M., & Puvanakrishnan, R. (2008) · Rheumatology International · doi:10.1007/s00296-007-0446-y · Cited by 32
Charoenphandhu, N., Teerapornpuntakit, J., Methawasin, M., Wongdee, K., Thongchote, K., & Krishnamra, N. (2008) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y08-037 · Cited by 31
Adrenaline-induced immunological changes are altered in patients with rheumatoid arthritis
Kittner, J. M. (2002) · British journal of rheumatology · doi:10.1093/rheumatology/41.9.1031 · Cited by 31
Serum Prolactin Concentrations in Male Patients with Rheumatoid Arthritis
SERIOLO, B., Ferretti, V., Sulli, A., FASCIOLO, D., & Cutolo, M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04224.x · Cited by 31
Adverse Pregnancy Outcomes and Risk of Subsequent Rheumatoid Arthritis
Ma, K. K., Nelson, J. L., Guthrie, K. A., Dugowson, C. E., & Gammill, H. S. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38247 · Cited by 30
Lotinun, S., Limlomwongse, L., & Krishnamra, N. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-76-2-218 · Cited by 30
Krishnamra, N., & SEEMOUNG, J. (1996) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y96-123 · Cited by 30
Why the gender difference in susceptibility to rheumatoid arthritis?
Brennan, P. M., & Silman, A. J. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.9.694 · Cited by 29
Prolactin in Ovarian Follicular Fluid Stimulates Endothelial Cell Proliferation
Castilla, A., García, C., Cruz-Soto, M. E., de la Escalera, G. M., Thébault, S. C., & Clapp, C. (2009) · Journal of Vascular Research · doi:10.1159/000231720 · Cited by 29
Self-citationGuy, M., McFadden, T. B., Cockrell, D. C., & Besser, T. E. (1994) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(94)77302-1 · Cited by 28
Prolactin inhibits the apoptosis of chondrocytes induced by serum starvation
Zermeño, C., Guzmán‐Morales, J., Macotela, Y., Nava, G., López-Barrera, F., Kouri, J. B., Lavalle, C. M., de la Escalera, G. M., & Clapp, C. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06766 · Cited by 27
Self-citationParity Status and the Development of Rheumatoid Arthritis
Silman, A. J. (1992) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1992.tb00799.x · Cited by 27
Bromocriptine and cyclosporin a combination therapy in rheumatoid arthritis
Dougados, M., Duchesne, L., & Amor, B. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780311022 · Cited by 27
Jørgensen, K. T., Harpsøe, M. C., Jacobsen, S., Jess, T., & Frisch, M. (2014) · Lara D. Veeken · doi:10.1093/rheumatology/keu150 · Cited by 27
Phenotypic and functional abnormalities of T lymphocytes in pathological hyperprolactinemia
Gerli, R., Riccardi, C., Nicoletti, I., Orlandi, S., Cernetti, C., Spinozzi, F., & Rambotti, P. (1987) · Journal of Clinical Immunology · doi:10.1007/bf00915056 · Cited by 26
Lotinun, S., Limlomwongse, L., & Krishnamra, N. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y98-016 · Cited by 26
The neuroendocrine immunology of rheumatoid arthritis
Chikanza, I. C. (1996) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(96)80018-5 · Cited by 25
The PRL –1149 G/T polymorphism and rheumatoid arthritis susceptibility
Lee, Y., Raychaudhuri, S., Cui, J., Vivo, I. D., Ding, B., Alfredsson, L. S., Padyukov, L., Costenbader, K. H., Seielstad, M. T., Graham, R., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24468 · Cited by 25
ZIMMER, J. P., Garza, C., Butte, N. F., & Goldman, A. S. (1998) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1998.tb00389.x · Cited by 24
Vasoinhibins regulate the inner and outer blood-retinal barrier and limit retinal oxidative stress
Zamarripa, D. A., Díaz‐Lezama, N., García, R. M., Balderas, J. C., Adán, N., Ledesma-Colunga, M. G., Arnold, E., Clapp, C., & Thébault, S. C. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00333 · Cited by 24
Self-citationThe Short Prolactin Receptor Predominates in Endothelial Cells of Micro- and Macrovascular Origin
Ricken, A. M., Traenkner, A., Merkwitz, C., Hummitzsch, K., Grosche, J., & Spanel‐Borowski, K. (2006) · Journal of Vascular Research · doi:10.1159/000097892 · Cited by 24
Rovenský, J., BAKOŠOVÁ, J., Koška, J., KSINANTOVA, L., Ježová, D., & Vigas, M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04225.x · Cited by 23
Eijsbouts, A. M. M., van den Hoogen, F. H. J., Laan, R. F. J. M., Sweep, F. C. G. J., Hermus, A. R. M. M., & van de Putte, L. B. A. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2002.001347 · Cited by 23
16K prolactin induces NF-kappaB activation in pulmonary fibroblasts
Macotela, Y., Mendoza-Milla, C., Corbacho, A., Cosı́o, G., Eiserich, J., Zentella‐Dehesa, A., de la Escalera, G. M., & Clapp, C. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.175r013 · Cited by 23
Self-citationKo, J., Ahn, Y.-L., & Cho, B.-N. (2003) · Molecules and Cells · doi:10.1016/s1016-8478(23)13736-8 · Cited by 23
Treatment of rheumatoid arthritis with the dopamine agonist quinagolide.
Eijsbouts, A. M. M., van den Hoogen, F. H. J., Laan, R. F. J. M., Hermus, A. R. M. M., Sweep, F. C. G. J., & van de Putte, L. B. A. (1999) · PubMed · Cited by 22
Prolactin and Growth Hormone Secretion in Stress
Reichlin, S. (1988) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2064-5_28 · Cited by 20
Short-term hyperprolactinemia decreases allergic inflammatory response of the lungs
Ochoa-Amaya, J. E., Hamasato, E. K., Tobaruela, C. N., Queiroz‐Hazarbassanov, N., Franci, J. A. A., Palermo‐Neto, J., Greiffo, F. R., Britto, A., Vieira, R. P., de Oliveira, A. P. L., et al. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.10.016 · Cited by 20
Breastfeeding-related Onset, Flare, and Relapse of Rheumatoid Arthritis
Hampl, J. S., & Papa, D. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2001.tb05511.x · Cited by 20
Kullich, W., & Klein, G. (1998) · Clinical Rheumatology · doi:10.1007/bf01451064 · Cited by 20
Mattsson, R., Mattsson, A., Hansson, I., Holmdahl, R., Rook, G. A. W., & Whyte, A. (1992) · Autoimmunity · doi:10.3109/08916939209035151 · Cited by 20
Tumour necrosis factor-α and apoptosis in the rat temporomandibular joint
Spears, R. D., Oakes, R., Bellinger, L. L., & Hutchins, B. (2003) · Archives of Oral Biology · doi:10.1016/s0003-9969(03)00175-4 · Cited by 19
Control of unremitting rheumatoid arthritis by the prolactin antagonist cabergoline
Erb, N. (2001) · British journal of rheumatology · doi:10.1093/rheumatology/40.2.237 · Cited by 19
Lemini, M., Ruíz‐Herrera, X., Ledesma-Colunga, M. G., Díaz‐Lezama, N., Ríos, E. A. D. L., López-Barrera, F., Méndez, I. G., de la Escalera, G. M., Macotela, Y., & Clapp, C. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2014 · Cited by 18
Self-citationToo, C. K. L., Knee, R., Pinette, A. L., Li, A. W., & Murphy, P. R. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)00240-2 · Cited by 18
Roman, O., Šereš, J., Herichová, I., Zeman, M., & Jur̀čovičová, J. (2003) · Chronobiology International · doi:10.1081/cbi-120021085 · Cited by 18
Jur̀čovičová, J., Stančíková, M., Švík, K., Ondrejicková, KRSOVÁ, D., Šereš, J., & Rokyta, R. (2001) · PubMed · Cited by 18
Nakajima, R., Ishida, M., Kamiya, C., Yoshimatsu, J., Suzuki, M., Hirota, A., Ikeda, T., & Harigaya, T. (2015) · Hypertension Research · doi:10.1038/hr.2015.99 · Cited by 16
The role of bromocriptine in the treatment of patients with active rheumatoid arthritis
Salesi, M., Sadeghi, S., Nasri, P., Namdarigharaghani, N., Farajzadegan, Z., & Hajalikhani, M. (2013) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12015 · Cited by 14
The effect of cabergoline on clinical and laboratory findings in active rheumatoid arthritis.
Mobini, M., Kashi, Z., Pour, A. R. M., & Adibi, E. (2011) · Europe PMC (PubMed Central) · Cited by 13
Reyes-Castillo, Z., Pereira-Suárez, A. L., Palafox‐Sánchez, C. A., Rangel‐Villalobos, H., Estrada‐Chávez, C., Oregon‐Romero, E., Angel-Chávez, L. I., Muñóz-Barrios, S., Bueno‐Topete, M. R., & Muñóz-Valle, J. F. (2013) · Gene · doi:10.1016/j.gene.2013.04.068 · Cited by 13
Kinetics of prolactin release in rheumatoid arthritis.
Jørgensen, C., Maziad, H., Bologna, C., & Sany, J. (1995) · PubMed · Cited by 13
Mg, G. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01268.x · Cited by 12
Thébault, S. C., González, C., García, C., Zamarripa, D. A., Nava, G., Vaca, L. A., López‐Casillas, F., de la Escalera, G. M., & Clapp, C. (2011) · Pharmaceuticals · doi:10.3390/ph4071052 · Cited by 12
Self-citationProlactinoma and systemic lupus erythematosus: do serum prolactin levels matter?
Li, M., Keiser, H. D., & Peeva, E. (2006) · Clinical Rheumatology · doi:10.1007/s10067-005-0117-x · Cited by 11
Rovenský, J., Imrich, R., Rádiková, Ž., Simorova, E., Greguska, O., Vigas, M., & Macho, L. (2005) · PubMed · Cited by 10
Arthritis and prolactin: A phylogenetic viewpoint
Adán, N., Ledesma-Colunga, M. G., Reyes-López, A. L., de la Escalera, G. M., & Clapp, C. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.01.011 · Cited by 9
Self-citationSubchondral vascularisation and osteoarthritis
Graf, J., Neusel, E., Freese, U., Simank, H.-G., & Niethard, F. U. (1992) · International Orthopaedics · doi:10.1007/bf00180198 · Cited by 9
Oral Contraceptives, Replacement Oestrogens and the Risk of Rheumatoid Arthritis
Hernández‐Ávila, M., Liang, M. H., Willett, W. C., Stampfer, M. J., Colditz, G. A., ROSNER, B. A., Chang, R. W., Hennekens, C. H., & Speizer, F. E. (1989) · Lara D. Veeken · doi:10.1093/rheumatology/xxviii.suppl_1.31 · Cited by 9
Krishnamra, N., & Cheeveewattana, V. (1994) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y94-218 · Cited by 8
Prolactin, growth hormone, and IGF-1 in ankles and plasma of adjuvant arthritic rats
Elhassan, A. A. A. (1999) · Scandinavian Journal of Rheumatology · doi:10.1080/03009749950155364 · Cited by 7
Serum prolactin levels in women with rheumatoid arthritis
Ghule, S., Dhotre, A., Gupta, M. M., Dharme, P. V., & Vaidya, S. (2009) · Cited by 6
A Novel Megakaryocyte Differentiation Factor from Mouse Placenta
Lin, J. D. (1999) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(99)00026-2 · Cited by 5
Does rheumatoid arthritis represent an adaptive, thrifty condition?
Reser, J. E., & Reser, W. W. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.07.041 · Cited by 3
Serum-Prolactin and the Association to Disease Activity in Patients with Rheumatoid Arthritis
Haga, H., Moreno, A., Andersen, D. T., & Peen, E. (2014) · Research in Endocrinology · doi:10.5171/2014.396352 · Cited by 3
Ho (2001) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200110)44:10 · Cited by 3
Yoshikawa, H., Nara, K., & Suzuki, N. (2006) · Current Rheumatology Reviews · doi:10.2174/157339706776876116 · Cited by 3
Parara, S., Seres, J., Rokyta, R., Stančíková, M., & Jurčovičová, J. (2003) · PubMed · Cited by 1
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“PRL has been reported to exhibit both pro-and antiinflammatory actions in different cell types (43).”
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Metadata
- Authors
- Clapp, C., Adán, N., Ledesma-Colunga, M. G., Solís-Gutiérrez, M., Triebel, J., & Martínez de la Escalera, G.
- Affiliations
- Universidad Nacional Autónoma de México (MX)
- Paracelsus Medizinische Privatuniversität (DE)
- Corresponding author
- Clapp, Carmen
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2016-03-29
- Volume
- 73
- Issue
- 15
- Pages
- 2929-2948
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11108309
- OpenAlex
- W2321665593
- Cited by
- 38
- References
- 272
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 1 · 2017: 3 · 2016: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dirección General Asuntos del Personal Académico, Universidad Nacional Autónoma de México (MX) (IN201315)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- rheumatoid arthritis, prolactin, vasoinhibin, sex differences, reproductive hormones, immune regulation, antiangiogenic activity, joint destruction, risk factors, therapeutic target
- MeSH terms
- Animals, Arthritis, Rheumatoid, Cartilage, Articular, Female, Humans, Immune Tolerance, Immunity, Cellular, Inflammation, Joints, Male, Prolactin, Reproduction, Sex Factors, Stress, Physiological, Stress, Psychological, Angiogenesis Inhibitors
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