The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Mitochondrial dynamics as regulators of cancer biology
Open accessAbstract
Mitochondria are dynamic organelles that supply energy required to drive key cellular processes, such as survival, proliferation, and migration. Critical to all of these processes are changes in mitochondrial architecture, a mechanical mechanism encompassing both fusion and fragmentation (fission) of the mitochondrial network. Changes to mitochondrial shape, size, and localization occur in a regulated manner to maintain energy and metabolic homeostasis, while deregulation of mitochondrial dynamics is associated with the onset of metabolic dysfunction and disease. In cancers, oncogenic signals that drive excessive proliferation, increase intracellular stress, and limit nutrient supply are all able to alter the bioenergetic and biosynthetic requirements of cancer cells. Consequently, mitochondrial function and shape rapidly adapt to these hostile conditions to support cancer cell proliferation and evade activation of cell death programs. In this review, we will discuss the molecular mechanisms governing mitochondrial dynamics and integrate recent insights into how changes in mitochondrial shape affect cellular migration, differentiation, apoptosis, and opportunities for the development of novel targeted cancer therapies.
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During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
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“However, while the mechanism underlying Mfn1 −/− lethality required further investigation, Mfn2 −/− mice died mid-gestation due to reduced trophoblast giant cells in the placenta and resulted in improper placental development, indicating that Mfn1 and Mfn2 are not functionally redundant [6, 7].”
Cited by
Keoh, L. Q., Chiu, C.-F., & Ramasamy, T. S. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10956-y · Cited by 66
Metadata
- Authors
- Trotta, A. P., & Chipuk, J. E.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2017-01-12
- Volume
- 74
- Issue
- 11
- Pages
- 1999-2017
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W2577310139
- Cited by
- 222
- References
- 31
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
