The DOI matches its Crossref record; 248 of the 249 references it cites were found in a registry or an index.
Mechanisms and consequences of intestinal dysbiosis
Open accessAbstract
The composition of the gut microbiota is in constant flow under the influence of factors such as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota itself. Natural variations in the gut microbiota can deteriorate to a state of dysbiosis when stress conditions rapidly decrease microbial diversity and promote the expansion of specific bacterial taxa. The mechanisms underlying intestinal dysbiosis often remain unclear given that combinations of natural variations and stress factors mediate cascades of destabilizing events. Oxidative stress, bacteriophages induction and the secretion of bacterial toxins can trigger rapid shifts among intestinal microbial groups thereby yielding dysbiosis. A multitude of diseases including inflammatory bowel diseases but also metabolic disorders such as obesity and diabetes type II are associated with intestinal dysbiosis. The characterization of the changes leading to intestinal dysbiosis and the identification of the microbial taxa contributing to pathological effects are essential prerequisites to better understand the impact of the microbiota on health and disease.
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“Regardless of balance, intestinal microbiota affects the functionality of various organs such as brain, liver, pancreas, intestine, and heart (60, 61).”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [61]
In the citing paper
“In addition, the immune system and the intestinal microbiota play a symbiotic function, maintaining a picture of non-inflammatory homeostasis: in cases of intestinal dysbiosis, there is an activation of the immune system, which leads to changes in the host's immunity.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [61]
In the citing paper
“These changes can impair the maturation of the innate immune system or lead to autoimmune diseases, such as type 1 diabetes (61).”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [61]
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Cites
2 retracted
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Cited by
Sorted by citations
Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review
Di Vincenzo, F., Del Gaudio, A., Petito, V., Lopetuso, L. R., & Scaldaferri, F. (2024) · Internal and Emergency Medicine · doi:10.1007/s11739-023-03374-w · Cited by 1,498
Hays, K. E., Pfaffinger, J. M., & Ryznar, R. J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2393270 · Cited by 541
Layered defense: how mucus and tight junctions seal the intestinal barrier
Capaldo, C., Powell, D. N., & Kalman, D. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1557-x · Cited by 387
Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling
Hamamah, S., Aghazarian, A., Nazaryan, A., Hajnal, A. S., & Covașă, M. (2022) · Biomedicines · doi:10.3390/biomedicines10020436 · Cited by 327
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy
Shen, Y., Fan, N., Ma, S., Cheng, X., Yang, X., & Wang, G. (2025) · MedComm · doi:10.1002/mco2.70168 · Cited by 404
Metadata
- Authors
- Weiss, G. A., & Hennet, T.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Hennet, Thierry
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2017-03-28
- Volume
- 74
- Issue
- 16
- Pages
- 2959-2977
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11107543
- OpenAlex
- W2599453585
- Cited by
- 775
- References
- 249
- Citations by year
- 2026: 86 · 2025: 145 · 2024: 124 · 2023: 112 · 2022: 121 · 2021: 72 · 2020: 59 · 2019: 30 · 2018: 18 · 2017: 7
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CRSII3_154488/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut dysbiosis, gut microbiota, microbial diversity, oxidative stress, bacteriophage induction, bacterial toxins, inflammatory bowel disease, obesity, type 2 diabetes, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Animals, Diet, Pharmaceutical Preparations, Humans, Immunity, Intestinal Mucosa, Intestines, Oxidative Stress, Inflammasomes, Dysbiosis
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