Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation
Open accessAbstract
Once viewed as a passive physiological state, sleep is a heterogeneous and complex sequence of brain states with essential effects on synaptic plasticity and neuronal functioning. Rapid-eye-movement (REM) sleep has been shown to promote calcium-dependent plasticity in principal neurons of the cerebral cortex, both during memory consolidation in adults and during post-natal development. This article reviews the plasticity mechanisms triggered by REM sleep, with a focus on the emerging role of kinases and immediate-early genes for the progressive corticalization of hippocampus-dependent memories. The body of evidence suggests that memory corticalization triggered by REM sleep is a systemic phenomenon with cellular and molecular causes.
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The ATP reduction was most pronounced in the RSC, a region that strongly synchronizes with the hippocampus during REM sleep, plays a central role in spatial memory formation, and is implicated in both the initiation and maintenance of REM sleep.
“This interpretation is supported by our observation that the ATP reduction was most pronounced in the RSC, a region that strongly synchronizes with the hippocampus during REM sleep, plays a central role in spatial memory formation, and is implicated in both the initiation and maintenance of REM sleep59,64.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [64]
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References 298 · Cited by 38
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- Authors
- Almeida-Filho, D. G., Queiroz, C. M., & Ribeiro, S.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Corresponding author
- Ribeiro, Sidarta
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2018-07-27
- Volume
- 75
- Issue
- 20
- Pages
- 3715-3740
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11105475
- OpenAlex
- W2883423584
- Cited by
- 38
- References
- 298
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 9 · 2017: 1
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (308775/20155, 408145/2016-1)
- Fundação de Amparo à Pesquisa do Rio Grande do Norte (003/2011)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2013/07699-0)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (783/13)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- REM sleep, memory consolidation, hippocampal-dependent memory, synaptic plasticity, calcium-dependent plasticity, kinases, immediate early genes, postnatal development, cerebral cortex
- MeSH terms
- Memory Consolidation, Animals, Hippocampus, Humans, Neuronal Plasticity, Sleep, REM, Synapses, Receptors, Neurotransmitter, Early Growth Response Protein 1
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