The DOI matches its Crossref record; 254 of the 254 references it cites were found in a registry or an index.
Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses
Open accessAbstract
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have shown the therapeutic potential effect of MSC or their derived products. However, the functional heterogeneity of MSC constitutes an important barrier for transferring these capabilities to the clinic. MSC heterogeneity depends on their origin (biological niche) or the conditions of potential donors (age, diseases or unknown factors). It is accepted that many culture conditions of the artificial niche to which they are subjected, such as O 2 tension, substrate and extracellular matrix cues, inflammatory stimuli or genetic manipulations can influence their resulting phenotype. Therefore, to attain a more personalized and precise medicine, a correct selection of MSC is mandatory, based on their functional potential, as well as the need to integrate all the existing information to achieve an optimal improvement of MSC features in the artificial niche.
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Cites
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Cited by
Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment
Yang, X., Li, Q., Liu, W., Zong, C., Wei, L., Shi, Y., & Han, Z. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-00983-5 · Cited by 120
Wu, M., Liu, X., Li, Z., Huang, X., Guo, H., Guo, X., Yang, X., Li, B., Xuan, K., & Jin, Y. (2021) · Cell Proliferation · doi:10.1111/cpr.13074 · Cited by 118
The potency of mesenchymal stem/stromal cells: does donor sex matter?
Maged, G., Abdelsamed, M. A., Wang, H., & Lotfy, A. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03722-3 · Cited by 42
Kawatani, K., Omana Suarez, G., Perkerson, R. B., Parent, E. E., Nambara, T., Knight, J. A., Parsons, T. M., Gupta, K., Shue, F., Alnobani, A., et al. (2025) · The Journal of Neuroscience · doi:10.1523/jneurosci.0606-24.2024 · Cited by 18
Mesenchymal Stem Cells and Reticulated Platelets: New Horizons in Multiple Myeloma
Mera Azaín, C. A., Vargas Pasquel, J. L., Quijano Gómez, S. M., & Rodríguez-Pardo, V. M. (2024) · Hematology Reports · doi:10.3390/hematolrep16040070 · Cited by 1
“First isolated from the BM, MSCs are also found in adipose tissue, endometrium, amniotic fluid, and umbilical cord, supporting hematopoiesis, immunity, and tissue regeneration [16,17].”
Metadata
- Authors
- Costa, L. A., Eiro, N., Fraile, M., Gonzalez, L. O., Saá, J., Garcia-Portabella, P., Vega, B., Schneider, J., & Vizoso, F. J.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2020-07-22
- Volume
- 78
- Issue
- 2
- Pages
- 447-467
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W3043859986
- Cited by
- 313
- References
- 254
- FWCI
- 17.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Costa, L. A., Eiro, N., Fraile, M., Gonzalez, L. O., Saá, J., Garcia-Portabella, P., Vega, B., Schneider, J., & Vizoso, F. J. (2021). Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-020-03600-0
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