Glycoconjugates in sperm function and gamete interactions: how much sugar does it take to sweet-talk the egg?
Open accessAbstract
Glycoconjugates in the mammalian reproductive tract are critical components of the molecular mechanisms that control sperm maturation, sperm transport and gamete interactions. In the oviduct of many species, sperm transport and maturation are regulated by protein-carbohydrate interactions that form a sperm reservoir. Subsequently, gamete interactions are mediated by the binding of lectin-like sperm proteins with carbohydrate moieties on the zona pellucida. The sperm glycocalyx is extensively modified during sperm transport and maturation. Multiple functions have been proposed for this dense carbohydrate layer overlying the sperm plasmalemma, and sperm-surface carbohydrates have been implicated in immune-mediated human infertility. The structure and function of glycoconjugates in the oviductal sperm reservoir, the zona pellucida, and on the sperm surface are reviewed.
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Glycan-recognition processes are a critical part of many sperm-egg interactions.
“Many early studies suggested that glycan-recognition processes were a critical part of many sperm -egg interactions (75, 938 -939).”
From Biological roles of glycans (2017) · cites this paper as [939]
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References 85 · Cited by 92
Research works printed but not linked: 4
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- Kirchhoff C. and Schröter S. (2001) New insights into the ori- gin, structure and role of CD52: a major component of the mammalian sperm glycocalyx [In Process Citation]. Cells Tis- sues Organs 168: 93 -104
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- CMLS, Cell. Mol. Life Sci. Vol. 60, 2003 Multi-author Review Article three differently charged CD52 forms, two of which remain sta- bly bound to sperm after capacitation. Mol. Reprod. Dev. 60: 89-96
- Authors
- Diekman, A. B.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- Corresponding author
- Diekman, A. B.
- Venue
- Cellular and Molecular Life Sciences CMLS
- Published
- 2003-02
- Volume
- 60
- Issue
- 2
- Pages
- 298-308
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11146057
- OpenAlex
- W1993235105
- Cited by
- 92
- References
- 85
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 11 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 4
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r03hd041524-02)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03 HD41524)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- glycoconjugates, sperm function, gamete interaction, sperm maturation, sperm transport, oviduct, sperm reservoir, zona pellucida, carbohydrate-protein interactions
- MeSH terms
- CD52 Antigen, Animals, Antigens, Neoplasm, Antigens, Surface, Female, Glycoconjugates, Glycoproteins, Humans, Infertility, Male, Models, Biological, Oviducts, Ovum, Sperm-Ovum Interactions, Spermatozoa, Zona Pellucida, Antigens, CD, Glycocalyx
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