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Cited by 96Pancreatic function and diabetesPluripotent Stem Cells ResearchDiabetes and associated disorders

The promise of stem cell-derived islet replacement therapy

Open access
Melton, Douglas·2021·Diabetologia
DOI 10.1007/s00125-020-05367-2PMC PMC8012315
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Abstract

Present-day treatments for people that are insulin dependent require multiple insulin injections, sometimes with an insulin pump, coupled with regular blood glucose monitoring. The availability of modified insulins, each with peaks of activity at varying times, has improved diabetes management. On the other hand, there have been impressive results leading to insulin independence by transplantation of cadaveric islets coupled with immune suppression. This review focuses on the possibility of treating diabetes with cellular transplants, specifically with the use of pluripotent stem cells, to produce a virtually unlimited and uniform supply of human islet-like clusters by directed differentiation. Prospects for improving the in vitro differentiation of human endocrine cells for the study of endocrine function and their possible clinical uses are also discussed. Graphical abstract

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Authors
Melton, D.
Affiliations
Harvard University (US)
Corresponding author
Melton, Douglas
ORCID
Melton, Douglas
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
2021-01-16
Volume
64
Issue
5
Pages
1030-1036
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/s00125-020-05367-2
PMC
PMC8012315
OpenAlex
W3125204220
Cited by
96
References
46
Citations by year
2026: 12 · 2025: 10 · 2024: 18 · 2023: 22 · 2022: 19 · 2021: 15
FWCI
4.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetologia (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Harvard Stem Cell Institute
  • JPB Foundation
  • JDRF
  • Howard Hughes Medical Institute
  • NIH
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
stem cell-derived islets, type 1 diabetes, pluripotent stem cells, directed differentiation, islet-like clusters, endocrine differentiation, insulin independence, islet transplantation, cell transplantation
MeSH terms
Animals, Cell Differentiation, Diabetes Mellitus, Humans, Islets of Langerhans, Islets of Langerhans Transplantation, Pluripotent Stem Cells

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