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A novel diabetes typology: towards precision diabetology from pathogenesis to treatment
Open accessAbstract
The current classification of diabetes, based on hyperglycaemia, islet-directed antibodies and some insufficiently defined clinical features, does not reflect differences in aetiological mechanisms and in the clinical course of people with diabetes. This review discusses evidence from recent studies addressing the complexity of diabetes by proposing novel subgroups (subtypes) of diabetes. The most widely replicated and validated approach identified, in addition to severe autoimmune diabetes, four subgroups designated severe insulin-deficient diabetes, severe insulin-resistant diabetes, mild obesity-related diabetes and mild age-related diabetes subgroups. These subgroups display distinct patterns of clinical features, disease progression and onset of comorbidities and complications, with severe insulin-resistant diabetes showing the highest risk for cardiovascular, kidney and fatty liver diseases. While it has been suggested that people in these subgroups would benefit from stratified treatments, RCTs are required to assess the clinical utility of any reclassification effort. Several methodological and practical issues also need further study: the statistical approach used to define subgroups and derive recommendations for diabetes care; the stability of subgroups over time; the optimal dataset (e.g. phenotypic vs genotypic) for reclassification; the transethnic generalisability of findings; and the applicability in clinical routine care. Despite these open questions, the concept of a new classification of diabetes has already allowed researchers to gain more insight into the colourful picture of diabetes and has stimulated progress in this field so that precision diabetology may become reality in the future.
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“Different subtypes/endotypes/clusters of T2D are associated with different risks of disease progression, 58,59 with particularly high risk for MASLD/MASH progression in those individuals with severe insulin resistance.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [59]
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The integrative biology of type 2 diabetes
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Self-citationIdentification of type 2 diabetes subgroups through topological analysis of patient similarity
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Molecular Choreography of Acute Exercise
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Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210
Self-citation(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 545
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Xourafa, G., Korbmacher, M., & Roden, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00898-1 · Cited by 274
Self-citationStefan, N., & Schulze, M. B. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00086-4 · Cited by 215
Precision subclassification of type 2 diabetes: a systematic review
Misra, S., Wagner, R. J., Özkan, B., Schön, M., Sevilla-González, M. D. R., Prystupa, K., Wang, C. C., Kreienkamp, R. J., CROMER, S. J., Rooney, M. R., et al. (2023) · Communications Medicine · doi:10.1038/s43856-023-00360-3 · Cited by 132
Metadata
- Authors
- Herder, C., & Roden, M.
- Affiliations
- Düsseldorf University Hospital (DE)
- Corresponding author
- Herder, Christian
- Roden, Michael
- Venue
- Diabetologia
- Published
- 2022-01-04
- Volume
- 65
- Issue
- 11
- Pages
- 1770-1781
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC9522691
- OpenAlex
- W4206342425
- Cited by
- 140
- References
- 69
- Citations by year
- 2026: 21 · 2025: 37 · 2024: 34 · 2023: 33 · 2022: 15
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Diabetologia (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Funders
- German Center for Diabetes Research
- German Federal Ministry of Education and Research
- German Federal Ministry of Health
- Ministry of Culture and Science of the State of North Rhine-Westphalia
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetes classification, diabetes subtypes, autoimmune diabetes, insulin-deficient diabetes, obesity-related diabetes, age-related diabetes, pathogenesis, diabetes complications, cardiovascular risk, diabetic nephropathy, hepatic steatosis, treatment stratification
- MeSH terms
- Diabetes Mellitus, Type 1, Humans, Hyperglycemia, Insulin Resistance, Comorbidity, Insulins
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