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Cited by 22Genetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance

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Laakso, M., Malkki, M., Kek�l�inen, P., Kuusisto, J., Deeb, S. S.·1995·Diabetologia
DOI 10.1007/s001250050328
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  • Point mutations in the HK-II gene found in type 2 diabetes are not close to glucose and ATP binding sites and are not associated with insulin resistance.

    “Several groups have looked for point mutations in the HK-II gene in individuals with type 2 diabetes, and, although several nucleotide substitutions have been found, none are close to the glucose and ATP binding sites and none have been associated with insulin resistance [203–205].”

    From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [204]

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References 23 · Cited by 22

Authors
Laakso, M., Malkki, M., Kek�l�inen, P., Kuusisto, J., & Deeb, S. S.
Affiliations
  • University of Washington (US)
  • University of Eastern Finland (FI)
ORCID
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
1995-04-01
Volume
38
Issue
5
Pages
617-622
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/s001250050328
OpenAlex
W2040827324
Cited by
22
References
23
Citations by year
2024: 1 · 2023: 1 · 2022: 1 · 2018: 2 · 2015: 1 · 2013: 2
FWCI
0.83
Type
journal article
Language
en
Open access
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Academy of Finland
  • Medical Research Council
  • National Heart, Lung, and Blood Institute (P01HL030086, HL3-0086)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
hexokinase 2, type 2 diabetes, insulin resistance, candidate gene association, skeletal muscle, adipose tissue, Finnish population
MeSH terms
Adipose Tissue, Alleles, Base Sequence, Blood Glucose, Diabetes Mellitus, Type 2, Exons, Female, Finland, Hexokinase, Homozygote, Humans, Insulin Resistance, Isoenzymes, Male, Middle Aged, Molecular Sequence Data, Polymorphism, Genetic, Reference Values, Polymorphism, Restriction Fragment Length, Glucose Clamp Technique, Point Mutation, DNA Primers, Muscle, Skeletal

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