Association of the glycogen synthase locus on 19q13 with NIDDM in Pima Indians
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DNA sequencing of the glycogen synthase gene has found either no mutations or rare nucleotide substitutions that cannot explain the defect in insulin-stimulated glycogen synthase activity in type 2 diabetes.
“The glycogen synthase gene has been the subject of intensive investigation, and DNA sequencing has revealed either no mutations or rare nucleotide substitutions that cannot explain the defect in insulin-stimulated glycogen synthase activity [223–225].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [223]
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References 29 · Cited by 53
- Authors
- Majer, M., Mott, D. M., Mochizuki, H., Rowles, J. C., Pedersen, O., Knowler, W. C., Bogardus, C., & Prochazka, M.
- Affiliations
- National Institutes of Health (US)
- Venue
- Diabetologia
- Published
- 1996-02-01
- Volume
- 39
- Issue
- 3
- Pages
- 314-321
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1982950623
- Cited by
- 53
- References
- 29
- Citations by year
- 2025: 1 · 2018: 3 · 2015: 2
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (1P41-RR03655, P41RR003655)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- glycogen synthase, glycogen synthase 1, chromosome 19q13, type 2 diabetes, Pima Indians, insulin resistance, skeletal muscle, genetic association, linkage analysis, insulin-stimulated glucose disposal, post-translational modification, genetic susceptibility
- MeSH terms
- Adult, Alleles, Arizona, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 9, Diabetes Mellitus, Type 2, Ethnicity, Female, Finland, Genetic Markers, Genotype, Glycogen Synthase, Humans, Indians, North American, Insulin Resistance, Japan, Genetic Linkage, Male, Molecular Sequence Data, Reference Values, Repetitive Sequences, Nucleic Acid, RNA, Messenger, Gene Expression, Polymerase Chain Reaction, DNA Primers, Muscle, Skeletal, Polymorphism, Single-Stranded Conformational
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