Failure to adequately adapt reduced insulin sensitivity with increased insulin secretion in women with impaired glucose tolerance
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Studies in high-risk subjects have shown reductions in the later second-phase insulin response to intravenous glucose, glucose potentiation of insulin release, pulsatile insulin secretion, oscillatory insulin release, and the ability of an oscillating glucose infusion to induce oscillations in insulin secretion.
“Studies in subjects at high risk including first degree relatives of subjects with Type 2 diabetes [121, 122], women with a history of gestational diabetes [100] or polycystic ovarian disease [96] and subjects with IGT [123, 124] have shown reductions in the later (second-phase) insulin response to intravenous glucose [121], in glucose potentiation of insulin release [123], in pulsatile insulin”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [123]
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References 45 · Cited by 60
- Authors
- Larsson, H., & Ahr�n, B.
- Affiliations
- Lund University (SE)
- ORCID
- Larsson, H.
- Venue
- Diabetologia
- Published
- 1996-08-01
- Volume
- 39
- Issue
- 9
- Pages
- 1099-1107
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2038530296
- Cited by
- 60
- References
- 45
- Citations by year
- 2022: 1 · 2019: 1 · 2016: 1 · 2014: 1
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- impaired glucose tolerance, insulin sensitivity, beta-cell adaptation, insulin secretion, acute insulin response, arginine stimulation, glucagon secretion, postmenopausal women, islet function
- MeSH terms
- Insulin Secretion, Arginine, Blood Glucose, Female, Glucagon, Glucose Tolerance Test, Humans, Insulin, Middle Aged, Random Allocation, Glucose Clamp Technique, Body Mass Index, Normal Distribution, Glucose Intolerance
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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