Infusion of pramlintide, a human amylin analogue, delays gastric emptying in men with IDDM
Open accessAbstract
Pramlintide, a human amylin analogue, reduces hyperglycaemia after meals in patients with insulin-dependent diabetes mellitus (IDDM). We investigated whether this was due to delayed gastric emptying. Eight men with uncomplicated IDDM were studied twice in a randomised, double-blind crossover design. Euglycaemia was maintained overnight by intravenous infusion of glucose and/or insulin and the following morning a 5-h infusion of pramlintide 25 micrograms/h or placebo was started at 08.00 hours. At 08.30 hours the patients injected their normal morning insulin dose subcutaneously and 30 min later ate a meal (600 kcal, 50% carbohydrate) of which the solid component was labelled with Technetium-99 m and the liquid with Indium-111 to quantify gastric emptying. Gamma-scintigraphic images were obtained every 20 min for the next 4 h. Insulin and glucose were infused as necessary to maintain blood glucose levels within 3 mmol/l of the pre-meal value. Compared to placebo, pramlintide significantly delayed emptying of both liquid (median lag time 69 vs 7.5 min) and solid (median lag time 150 vs 44.5 min) components of the meal. Pramlintide delayed gastric emptying so much that t50 values could not be calculated for solid or liquid. Amylin agonists such as pramlintide may, therefore, be of value in improving glycaemic control in IDDM by modifying gastric emptying.
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Injection of pramlintide prior to meals acts to suppress glucagon secretion, delay gastric emptying, and promote satiety.
“Injection prior to meals acts to suppress glucagon secretion, delay gastric emptying, and promote satiety (247-250).”
From The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2021) · cites this paper as [247]
The Discussion reports that pramlintide delayed gastric emptying in men with insulin-dependent diabetes. The study administered pramlintide by intravenous infusion, not a pre-meal injection; our copy does not report suppression of glucagon secretion or promotion of satiety. (LLM, conf=0.90)
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Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419 · see citing works
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Anti-obesity therapy: from rainbow pills to polyagonists
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Effects of pramlintide, an amylin analogue, on gastric emptying in type 1 and 2 diabetes mellitus
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The effect of single doses of pramlintide on gastric emptying of two meals in men with IDDM
Kong, M.-F., Stubbs, T. A., King, P., Macdonald, I. A., Lambourne, J. E., Blackshaw, P. E., Perkins, A. C., & Tattersall, R. B. (1998) · Diabetologia · doi:10.1007/s001250050949 · Cited by 106 · see citing works
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Continuous Glucose Monitoring in Gastroparesis
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- Authors
- Kong, M.-F., King, P., Macdonald, I. A., Stubbs, T. A., Perkins, A. C., Blackshaw, P. E., Moyses, C., & Tattersall, R. B.
- Affiliations
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Venue
- Diabetologia
- Published
- 1997-01-09
- Volume
- 40
- Issue
- 1
- Pages
- 82-88
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2027629911
- Cited by
- 131
- References
- 1
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 5
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- pramlintide, amylin analogues, gastric emptying, type 1 diabetes, postprandial hyperglycemia, glycemic control
- MeSH terms
- Adult, Amyloid, Blood Glucose, Diabetes Mellitus, Type 1, Double-Blind Method, Food, Gastric Emptying, Humans, Hypoglycemic Agents, Infusions, Intravenous, Insulin, Male, Time Factors, Cross-Over Studies, Islet Amyloid Polypeptide
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