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Time of non-invasive ventilation
Abstract
Non-invasive ventilation (NIV) is a safe, versatile and effective technique that can avert side effects and complications associated with endotracheal intubation. The success of NIV relies on several factors, including the type and severity of acute respiratory failure, the underlying disease, the location of treatment, and the experience of the team. The time factor is also important. NIV is primarily used to avert the need for endotracheal intubation in patients with early-stage acute respiratory failure and post-extubation respiratory failure. It can also be used as an alternative to invasive ventilation at a more advanced stage of acute respiratory failure or to facilitate the process of weaning from mechanical ventilation. NIV has been used to prevent development of acute respiratory failure or post-extubation respiratory failure. The number of days of NIV and hours of daily use differ, depending on the severity and course of the acute respiratory failure and the timing of application. In this review article, we analyse, compare and discuss the results of studies in which NIV was applied at various times during the evolution of acute respiratory failure.
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“Anxiety and depression are common psychological comorbidities, which aggravate the clinical situation (16).”
From Promoting Acceptance and Adherence to Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial. (2022) · cites this paper as [16]
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Self-citationPlace de la ventilation non invasive dans les soins palliatifs et en fin de vie
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NIV failure in respiratory failure: an analysis
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“Moreover, NIV avoids intubation for a wide number of critical patients (Nava et al., 2006; Nava & Hill, 2009).”
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“Furthermore, delayed intubation in patients who fail NIV or HFNCs has been associated with increased mortality, highlighting the importance of close monitoring and timely escalation to invasive MV when necessary [36,37].”
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“…of nosocomial pneumonia (NP), increased risk of aspiration, tracheal injury, greater patient discomfort, and frequent need for sedatives [4–6 NIV, however, presents some issues related to its application, as patient’s discomfort can lead to non-compliance and, consequently, to interface…”
Self-citationPapalampidou, A., Bibaki, E., Boutlas, S., Pantazopoulos, I. N., Athanasiou, N., Moylan, M., Vlachakos, V., Grigoropoulos, V., Eleftheriou, K., Daniil, Z. D., et al. (2020) · ERJ Open Research · doi:10.1183/23120541.00114-2020 · Cited by 4
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“There is also evidence for the use of NIV in improving respiratory outcomes postoperatively, including reduction in pulmonary morbidity, mortality, hypoxemia and length of stay (30-35), for allowing early liberation from the ventilator (36), and for avoiding reintubation following planned extubation (37,38), although…”
BackgroundSadanandan, A., George, S., Mohamed, N. S., & Puthiyaveettil, S. K. (2024) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-024-03724-3 · Cited by 3
“(iii) Persistent hypoxemia despite supplemental oxygen therapy This intervention has dramatically decreased the rate of endotracheal intubation, which in turn has reduced the incidence of ventilator associated pneumonia, hospital stay length, and overall mortality [4, 5].”
Ventilação Não Invasiva: Experiência de um Serviço de Medicina Interna
Costa, J. C. (2018) · Medicina Interna · doi:10.24950/rspmi/original/78/1/2018 · Cited by 3
Panzuti, G., Giancotti, G., Nava, S., & Vega, M. L. (2025) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2025.2529540 · Cited by 2
“The endotracheal tube contributes to patient discomfort, often requiring sedatives to manage anxiety and ensure compliance [8].”
Self-citationWinck, J. C., & Gonçalves, M. (2011) · Journal of Medicine and the Person · doi:10.1007/s12682-011-0075-9 · Cited by 2
“NPPV should, however, be considered in some cases an alternative to invasive mechanical ventilation rather than its replacement [8–12].”
BackgroundLima, F. V. S. D. O., Hajjar, L. A., de Almeida, J. P., Ramalho, S. H. R., Chiappa, G. R., Cipriano, G. F. B., Cahalin, L. P., de Carvalho, C. R., & Cipriano, G. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-021-06078-z · Cited by 2
Abdelfattah, R. A., Ali, Y. M., Aziz, M. O. A., Abdelaziz, A. O., & Mohamed, B. I. (2023) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2023.293467 · Cited by 2
von Düring, S., Chevalley, B., Wozniak, H., Desmettre, T., Quintard, H., Suppan, L., & Fehlmann, C. A. (2025) · BMC Emergency Medicine · doi:10.1186/s12873-025-01193-0 · Cited by 2
“NIV improves outcomes in COPD exacerbations by reducing work of breathing, enhancing gas exchange, and lowering intubation rates, morbidity, hospital length of stay, and mortality compared to standard oxygen therapy [2, 5, 44–46].”
Vaschetto, R., Longhini, F., & Navalesi, P. (2016) · European Respiratory Society eBooks · doi:10.1183/2312508x.10002316 · Cited by 2
Self-citationClinical guidelines on use of noninvasive ventilation in patients with acute respiratory failure
Editorial, A. (2018) · PULMONOLOGIYA · doi:10.18093/0869-0189-2018-28-1-13-31 · Cited by 2
“Двухуровневая НВЛ показана лицам с обострением ХОБЛ в следующих клинических ситуациях [10]: • для предотвращения ОРА, т.”
Non-Invasive Ventilation in COVID-19 Related Respiratory Failure
Syafa’ah, I. (2021) · Jurnal Respirasi · doi:10.20473/jr.v7-i.3.2021.139-144 · Cited by 2
“The indications for the use of NIV are broadly (1) to prevent impending (not yet occurring) acute or post-extubation failure, (2) in the early phase, when respiratory failure has occurred, to prevent the need for endotracheal intubation, and (3) as an alternative to invasive ventilation in the more severe stages of ac…”
BackgroundHighlights from the Respiratory Failure and Mechanical Ventilation 2022 Conference
Viegas, P., Ageno, E., Corsi, G., Tagariello, F., Razakamanantsoa, L., Vilde, R., Ribeiro, C. S. M. F., Heunks, L. M. A., Patout, M., & Fisser, C. (2022) · ERJ Open Research · doi:10.1183/23120541.00467-2022 · Cited by 3
Parrilla-Gómez, F. J., Marín‐Corral, J., Castellví-Font, A., Pérez-Terán, P., Picazo, L., Ravelo-Barba, J., Campano-García, M., Festa, O., Restrepo, M. I., & Masclans, J. R. (2023) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2023.11.006 · Cited by 2
Nava, S., & Mercadante, S. (2010) · Springer eBooks · doi:10.1007/978-3-642-15742-4_49 · Cited by 1
“Therefore, the time to start and the time to eventually stop NIV are critical in a non-protected environment [ 7 ].”
BackgroundSelf-citationFrom ICU to Emergency Department: 9-Year Experience with Non-Invasive Ventilation for COPD
Ibrahim, I., Phua, J., Goh, E., Mahadevan, M., & Lim, T. (2014) · Hong Kong Journal of Emergency Medicine · doi:10.1177/102490791402100302 · Cited by 1
“In a survey by Hess et al of 132 academic EDs in the United States, NIV was used one or more times per week in 92% of EDs.13 Sixty-seven percent of EDs in the United Kingdom,14 and 46% in the European countries use NIV.15,16 Ironically, randomised controlled studies (RCT) on this field were often performed in ICU,17-1…”
BackgroundInfluentialNIV: indication in case of acute respiratory failure in obstructive pulmonary diseases
Ambrosino, N., & Corrado, A. (2008) · European Respiratory Society eBooks · doi:10.1183/1025448x.00041002 · Cited by 1
“Based on these observations, NPPV has been proposed as the first-line ventilatory strategy in this condition with different timing and location according to the level of ARF severity [10, 11, 34, 35].”
BackgroundManagement of Respiratory Emergencies in Chronic Neuromuscular Disease
Gaytant, M. A., & Wijkstra, P. J. (2022) · Springer eBooks · doi:10.1007/978-3-030-91932-0_4 · Cited by 1
Tinoco, H. A., Perdomo-Hurtado, L., Cruz, J. A. H., Escobar-Serna, J. F., Jaramillo-Robledo, O., Aguirre-Ospina, O. D., Hurtado-Hernández, M., & López-Guzmán, J. (2023) · Medicina · doi:10.3390/medicina59081372 · Cited by 1
“It has been explored for facilitating endotracheal tube removal after invasive mechanical ventilation, aiming to prevent reintubation post-extubation [7,9,10].”
BackgroundDesign, Modeling, and Control of a Soft Abdominal Compression Robot for Respiratory Assistance
Yuan, S., Zhou, S., Wang, Y., Hou, M., & Fei, Y. (2025) · Soft Robotics · doi:10.1089/soro.2024.0088 · Cited by 1
Indications for Noninvasive Respiratory Support
Kugelman, A., & Martinón‐Torres, F. (2014) · Springer eBooks · doi:10.1007/978-3-642-01219-8_17 · Cited by 1
Study of non-invasive mechanical ventilation in ICU patients : clinical and prognostic relevance
Momtaz, O. M., Elkhateeb, A. F., & Amin, E. (2019) · Fayoum University Medical Journal/Fayoum University Medical Journal · doi:10.21608/fumj.2019.55053 · Cited by 1
Alnajada, A., Blackwood, B., Mobrad, A. M., Akhtar, A., & Shyamsundar, M. (2021) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2020-000853 · Cited by 1
Ventilação Não-Invasiva na Falência Respiratória Aguda
Costa, B., Amaral, R., Vieira, M. S., Maia, J. M., Barros, N. C., & Esteves, F. (2021) · Medicina Interna · doi:10.24950/o/320/20/2/2021 · Cited by 1
Non-invasive ventilation in the treatment of acute respiratory failure with COVID-19
Nasibova, E. M., & Pashaev, C. N. (2020) · Journal of Anesthesia & Critical Care Open Access · doi:10.15406/jaccoa.2020.12.00445 · Cited by 1
Respiratory Failure in Acute Medical Unit
Boutrus, T. S. (2023) · Journal of Internal Medicine and Emergency Research · doi:10.37191/mapsci-2582-7367-4(3)-064 · Cited by 1
Quando iniziare (o meno) il trattamento ventilatorio
Nava, S., & Fanfulla, F. (2010) · Springer eBooks · doi:10.1007/978-88-470-1548-7_5 · Cited by 1
Self-citationNoninvasive Positive-Pressure Ventilation Therapy in Patients with COPD
Uçar, Z. Z. (2012) · InTech eBooks · doi:10.5772/29517
Metadata
- Authors
- Nava, S., Navalesi, P., & Conti, G.
- Affiliations
- Istituti Clinici Scientifici Maugeri (IT)
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Navalesi, Paolo
- Venue
- Intensive Care Medicine
- Published
- 2006-02-14
- Volume
- 32
- Issue
- 3
- Pages
- 361-370
- ISSN
- 0342-4642 (ISSN-L)
- 1432-1238
- OpenAlex
- W2081743814
- Cited by
- 144
- References
- 88
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 15 · 2022: 7 · 2021: 16 · 2020: 6 · 2019: 10 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 7
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Intensive Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- non-invasive ventilation, timing of ventilation initiation, acute respiratory failure, post-extubation respiratory failure, weaning from mechanical ventilation, endotracheal intubation avoidance
- MeSH terms
- Humans, Intensive Care Units, Intubation, Intratracheal, Italy, Respiration, Artificial, Respiratory Insufficiency, Ventilator Weaning, Pneumonia, Ventilator-Associated
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