Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patients
Open accessAbstract
PURPOSE: Selective digestive microbial decontamination (SDD) is hypothesized to benefit patients in intensive care (ICU) by suppressing Gram-negative potential pathogens from the colon without affecting the anaerobic intestinal microbiota. The purpose of this study was to provide more insight to the effects of digestive tract and oropharyngeal decontamination on the intestinal microbiota by means of a prospective clinical trial in which faecal samples were collected from ICU patients for intestinal microbiota analysis. METHODS: The faecal samples were collected from ICU patients enrolled in a multicentre trial to study the outcome of SDD and selective oral decontamination (SOD) in comparison with standard care (SC). Fluorescent in situ hybridization (FISH) was used to analyze the faecal microbiota. The numbers of bacteria from different bacterial groups were compared between the three regimens. RESULTS: The total counts of bacteria per gram faeces did not differ between regimens. The F. prausnitzii group of bacteria, representing an important group among intestinal microbiota, was significantly reduced in the SDD regimen compared to the SC and SOD. The Enterobacteriaceae were significantly suppressed during SDD compared to both SOD and SC; enterococci increased in SDD compared to both other regimens. CONCLUSIONS: The composition of the intestinal microbiota is importantly affected by SDD. The F. prausnitzii group was significantly suppressed during SDD. This group of microbiota is a predominant producer of butyrate, the main energy source for colonocytes. Reduction of this microbiota is an important trade-off while reducing gram-negative bacteria by SDD.
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Topical oral decontamination decreases the bacterial burden of the oropharynx and decreases immigration from the source community.
“topical oral decontamination, decrease the bacterial burden of the oropharynx and decrease immigration from the source community”
From The microbiome and critical illness (2016) · cites this paper as [44]
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References 44 · Cited by 63
- Authors
- Benus, R. F., Harmsen, H. J., Welling, G. W., Spanjersberg, R., Zijlstra, J. G., Degener, J. E., & van der Werf, T. S.
- Affiliations
- University Medical Center Groningen (NL)
- Venue
- Intensive Care Medicine
- Published
- 2010-03-16
- Volume
- 36
- Issue
- 8
- Pages
- 1394-1402
- ISSN
- 0342-4642 (ISSN-L)
- 1432-1238
- PMC
- PMC2900589
- OpenAlex
- W2079005986
- Cited by
- 63
- References
- 44
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Intensive Care Medicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc)
- Funders
- Universitair Medisch Centrum Groningen
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- gut microbiota, intensive care unit patients, Faecalibacterium prausnitzii, Enterobacteriaceae, Enterococcus, Gram-negative bacteria, butyrate, fecal microbiota composition
- MeSH terms
- Decontamination, Feces, Gram-Negative Bacteria, Humans, Intensive Care Units, Intestines, Middle Aged, Netherlands, Oropharynx, Antibiotic Prophylaxis, Metagenome
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