The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Effects of fluids on microvascular perfusion in patients with severe sepsis
Open accessAbstract
PurposeTo evaluate the effects of fluid administration on microcirculatory alterations in sepsis.MethodsWith a Sidestream Dark Field device, we evaluated the effects of fluids on the sublingual microcirculation in 60 patients with severe sepsis. These patients were investigated either within 24 h (early, n = 37) or more than 48 h (late, n = 23) after a diagnosis of severe sepsis. Hemodynamic and microcirculatory measurements were obtained before and 30 min after administration of 1,000 ml Ringer’s lactate (n = 29) or 400 ml 4% albumin (n = 31) solutions.ResultsFluid administration increased perfused small vessel density from 3.5 (2.9–4.3) to 4.4 (3.7–4.9) n/mm (p < 0.01), through a combined increase in the proportion of perfused small vessels from 69 (62–76) to 79 (71–83) %, p < 0.01) and in small vessel density from 5.3 (4.4–5.9) to 5.6 (4.8–6.3) n/mm (p < 0.01). Importantly, microvascular perfusion increased in the early but not in the late phase of sepsis: the proportion of perfused small vessels increased from 65 (60–72) to 80 (75–84) % (p < 0.01) in the early phase and from 75 (66–80) to 74 (67–81) (p = ns) in the late phase. These microvascular effects of fluids were not related to changes in cardiac index (R2 = 0.05, p = ns) or mean arterial pressure (R2 = 0.04, p = ns).ConclusionsIn this non-randomized trial, fluid administration improved microvascular perfusion in the early but not late phase of sepsis. This effect is independent of global hemodynamic effects and of the type of solution.
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Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
Dellinger, R. P., Levy, M. M., Carlet, J. M., Bion, J., Parker, M. M., Jaeschke, R., Reinhart, K., Angus, D. C., Brun-Buisson, C., Beale, R., et al. (2008) · Intensive Care Medicine · doi:10.1007/s00134-007-0934-2 · Cited by 6,772
Self-citation2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E., Angus, D., Cook, D., Cohen, J., Opal, S. M., Vincent, J.-L., & Ramsay, G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050454.01978.3b · Cited by 5,995
Self-citationComparison of Two Fluid-Management Strategies in Acute Lung Injury
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa062200 · Cited by 3,538
Intensive insulin therapy and pentastarch resuscitation in severe sepsis
Brunkhorst, F. M., Engel, C., Bloos, F., Meier-Hellmann, A., Ragaller, M., Weiler, N., Moerer, O., Gruendling, M., Oppert, M., Grond, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070716 · Cited by 2,921
Microvascular Blood Flow Is Altered in Patients with Sepsis
De Backer, D., Creteur, J., Preiser, J.-C., Dubois, M.-J., & Vincent, J.-L. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200109-016oc · Cited by 1,473
Self-citationSakr, Y., Dubois, M.-J., De Backer, D., Creteur, J., & Vincent, J.-L. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000138558.16257.3f · Cited by 1,266
Self-citationHow to evaluate the microcirculation: report of a round table conference
De Backer, D., Hollenberg, S., Boerma, C., Goedhart, P., Büchele, G., Ospina-Tascon, G., Dobbe, I., & Ince, C. (2007) · Critical Care · doi:10.1186/cc6118 · Cited by 830
Self-citationTrzeciak, S., Dellinger, R. P., Parrillo, J. E., Guglielmi, M., Bajaj, J., Abate, N. L., Arnold, R. C., Colilla, S., Zanotti, S., & Hollenberg, S. M. (2007) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2006.08.021 · Cited by 609
Nitroglycerin in septic shock after intravascular volume resuscitation
Spronk, P. E., Ince, C., Gardien, M. J., Mathura, K. R., Straaten, H. M. O.-V., & Zandstra, D. F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11393-6 · Cited by 541
Cited by
Fluid challenges in intensive care: the FENICE study: A global inception cohort study
on behalf of the FENICE Investigators and the ESICM Trial Group, Cecconi, M., Hofer, C., Teboul, J.-L., Pettila, V., Wilkman, E., Molnar, Z., Della Rocca, G., Aldecoa, C., Artigas, A., et al. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-3850-x · Cited by 573
Self-citationCecconi, M., Hernandez, G., Dunser, M., Antonelli, M., Baker, T., Bakker, J., Duranteau, J., Einav, S., Groeneveld, A. B. J., Harris, T., et al. (2019) · Intensive Care Medicine · doi:10.1007/s00134-018-5415-2 · Cited by 128
Self-citationBorthwick, H.-A., Brunt, L. K., Mitchem, K. L., & Chaloner, C. (2012) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1258/acb.2011.011227 · Cited by 48
Metadata
- Authors
- Ospina-Tascon, G., Neves, A. P., Occhipinti, G., Donadello, K., Büchele, G., Simion, D., Chierego, M.-L., Silva, T. O., Fonseca, A., Vincent, J.-L., & De Backer, D.
- Venue
- Intensive Care Medicine
- Published
- 2010-03-11
- Volume
- 36
- Issue
- 6
- Pages
- 949-955
- ISSN
- 0342-4642 (ISSN-L)
- 1432-1238
- OpenAlex
- W2048876919
- Cited by
- 323
- References
- 24
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- green
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