The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Can procalcitonin help identify associated bacterial infection in patients with severe influenza pneumonia? A multicentre study
Open accessAbstract
Purpose To determine whether procalcitonin (PCT) levels could help discriminate isolated viral from mixed (bacterial and viral) pneumonia in patients admitted to the intensive care unit (ICU) during the A/H1N1v2009 influenza pandemic.Methods A retrospective observational study was performed in 23 French ICUs during the 2009 H1N1 pandemic. Levels of PCT at admission were compared between patients with confirmed influenzae A pneumonia associated or not associated with a bacterial co-infection.Results Of 103 patients with confirmed A/H1N1 infection and not having received prior antibiotics, 48 (46.6%; 95% CI 37-56%) had a documented bacterial co-infection, mostly caused by Streptococcus pneumoniae (54%) or Staphylococcus aureus (31%). Fifty-two patients had PCT measured on admission, including 19 (37%) having bacterial co-infection. Median (range 25-75%) values of PCT were significantly higher in patients with bacterial co-infection: 29.5 (3.9-45.3) versus 0.5 (0.12-2) μg/l (P < 0.01). For a cut-off of 0.8 μg/l or more, the sensitivity and specificity of PCT for distinguishing isolated viral from mixed pneumonia were 91 and 68%, respectively. Alveolar condensation combined with a PCT level of 0.8 μg/l or more was strongly associated with bacterial co-infection (OR 12.9, 95% CI 3.2-51.5; P < 0.001).Conclusions PCT may help discriminate viral from mixed pneumonia during the influenza season. Levels of PCT less than 0.8 μg/l combined with clinical judgment suggest that bacterial infection is unlikely.
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“Only three studies excluded participants based on antibiotic use and reported coinfection rates of 12·2%, 26·7%, and 46·6%.28, 34, 36”
From The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis. (2016) · cites this paper as [34]
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“A French study measured levels of procalcitonin (PCT) – a recognised marker of bacterial infection, in patients with H1N1 influenza pneumonia admitted to hospital and was able to conclude that levels of 0·8 μg/l or more discriminated well between isolated viral and mixed bacterial and viral pneumonia.”
From Bacterial and viral infections associated with influenza (2013) · cites this paper as [39]
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Procalcitonin increase in early identification of critically ill patients at high risk of mortality*
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Streptococcus pneumoniae coinfection is correlated with the severity of H1N1 pandemic influenza
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Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis.
Klein, E. Y., Monteforte, B., Gupta, A., Jiang, W., May, L., Hsieh, Y., & Dugas, A. (2016) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12398 · Cited by 574
New Approaches to Sepsis: Molecular Diagnostics and Biomarkers
Reinhart, K., Bauer, M. W., Riedemann, N. C., & Hartog, C. S. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-12 · Cited by 546
MacIntyre, C. R., Chughtai, A. A., Barnes, M., Ridda, I., Seale, H., Toms, R., & Heywood, A. (2018) · BMC Infectious Diseases · doi:10.1186/s12879-018-3548-0 · Cited by 323
Contou, D., Claudinon, A., Pajot, O., Micaëlo, M., Flandre, P. L., Dubert, M., Cally, R., Logre, E., Fraissé, M., Mentec, H., et al. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-00736-x · Cited by 324
Metadata
- Authors
- Cuquemelle, E., Soulis, F., Villers, D., Roche-Campo, F., Ara Somohano, C., Fartoukh, M., Kouatchet, A., Mourvillier, B., Dellamonica, J., Picard, W., Schmidt, M., Boulain, T., Brun-Buisson, C., & A/H1N1 REVA-SRLF Study Group
- Affiliations
- Hôpital Charles-Nicolle (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Centre Hospitalier Universitaire de Nice (FR)
- Centre Hospitalier De Pau (FR)
- Centre hospitalier universitaire d'Orléans (FR)
- Venue
- Intensive Care Medicine
- Published
- 2011-03-03
- Volume
- 37
- Issue
- 5
- Pages
- 796-800
- ISSN
- 0342-4642 (ISSN-L)
- 1432-1238
- PMC
- PMC7080069
- OpenAlex
- W1997205563
- Cited by
- 109
- References
- 15
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 9 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 11 · 2014: 8 · 2013: 6 · 2012: 17
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Intensive Care Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Société de Réanimation de Langue Française
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Keywords
- procalcitonin, bacterial co-infection, influenza pneumonia, H1N1 influenza, Streptococcus pneumoniae, Staphylococcus aureus, intensive care unit patients, diagnostic biomarkers, 2009 H1N1 pandemic
- MeSH terms
- Adult, Bacterial Infections, Calcitonin, Female, France, Humans, Influenza, Human, Male, Middle Aged, Pneumonia, Protein Precursors, Retrospective Studies, Sensitivity and Specificity, Severity of Illness Index, Biomarkers, Calcitonin Gene-Related Peptide, Influenza A Virus, H1N1 Subtype
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