Cited by 111Nosocomial Infections in ICUSepsis Diagnosis and TreatmentClinical Nutrition and Gastroenterology

The DOI matches its Crossref record; 154 of the 156 references it cites were found in a registry or an index.

Selective decontamination of the digestive tract: the mechanism of action is control of gut overgrowth

Silvestri, Luciano, de la Cal, Miguel A., van Saene, Hendrick K. F.·2012·Intensive Care Medicine

Open this paper in CoChat — free account

Abstract

Purpose Gut overgrowth is the pathophysiological event in the critically ill requiring intensive care. In relation to the risk of developing a clinically important outcome, gut overgrowth is defined as ≥10(5) potential pathogens including 'abnormal' aerobic Gram-negative bacilli (AGNB), 'normal' bacteria and yeasts, per mL of digestive tract secretion. Surveillance samples of throat and gut are the only samples to detect overgrowth. Gut overgrowth is the crucial event which precedes both primary and secondary endogenous infection, and a risk factor for the development of de novo resistance. Selective decontamination of the digestive tract (SDD) is an antimicrobial prophylaxis designed to control overgrowth.Methods There have been 65 randomised controlled trials of SDD in 15,000 patients over 25 years and 11 meta-analyses, which are reviewed.Results and conclusions These trials demonstrate that the full SDD regimen using parenteral and enteral antimicrobials reduces lower airway infection by 72 %, blood stream infection by 37 %, and mortality by 29 %. Resistance is also controlled. Parenteral cefotaxime which reaches high salivary and biliary concentrations eradicates overgrowth of 'normal' bacteria such as Staphylococcus aureus in the throat. Enteral polyenes control 'normal' Candida species. Enteral polymyxin and tobramycin, eradicate, or prevent gut overgrowth of 'abnormal' AGNB. Enteral vancomycin controls overgrowth of 'abnormal' methicillin-resistant S. aureus. SDD controls overgrowth by achieving high antimicrobial concentrations effective against 'normal' and 'abnormal' potential pathogens rather than by selectivity.

Integrity signals

Registry

Crossref · 10.1007/s00134-012-2690-1

Cites

154 of 154 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias)
Guyatt, G. H., Oxman, A. D., Vist, G., Kunz, R., Brozek, J., Alonso-Coello, P., Montori, V., Akl, E. A., Djulbegovic, B., & Falck-Ytter, Y. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.017 · Cited by 2,798
Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis
Kohanski, M. A., DePristo, M. A., & Collins, J. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.003 · Cited by 985
Changing Pharyngeal Bacterial Flora of Hospitalized Patients: Emergence of Gram-Negative Bacilli
Johanson, W. G., Pierce, A. K., & Sanford, J. P. (1969) · New England Journal of Medicine · doi:10.1056/nejm196911202812101 · Cited by 910
Decontamination of the digestive tract and oropharynx in ICU patients
de Smet, A. M. G. A., Kluytmans, J. A. J. W., Cooper, B. S., Mascini, E. M., Benus, R. F. J., van der Werf, T. S., van der Hoeven, J. G., Pickkers, P., Bogaers-Hofman, D., van der Meer, N. J. M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0800394 · Cited by 813
The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients
Stoutenbeek, C. P., SAENE, H. K. F. V., Miranda, D. R., & Zandstra, D. F. (1984) · Intensive Care Medicine · doi:10.1007/bf00259435 · Cited by 711
Antibiotic Resistance Among Gram-Negative Bacilli in US Intensive Care Units
Neuhauser, M. M., Weinstein, R. A., Rydman, R. J., Danziger, L. H., Karam, G. H., & Quinn, J. P. (2003) · JAMA · doi:10.1001/jama.289.7.885 · Cited by 672
Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial
de Jonge, E., Schultz, M. J., Spanjaard, L., Bossuyt, P. M., Vroom, M. B., Dankert, J., & Kesecioğlu, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14409-1 · Cited by 585
Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients
Rayes, N., Seehofer, D., Hansen, S., Boucsein, K., Müller, A., Serke, S., Bengmark, S., & Neuhaus, P. (2002) · Transplantation · doi:10.1097/00007890-200207150-00021 · Cited by 488
Controlled Clinical Trial of Selective Decontamination for the Treatment of Severe Acute Pancreatitis
Luiten, E. J. T., Hop, W. C. J., Lange, J. F., & Bruining, H. A. (1995) · Annals of Surgery · doi:10.1097/00000658-199507000-00010 · Cited by 454
Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials
D’Amico, R., Pifferi, S., Leonetti, C., Torri, V., Tinazzi, A., & Liberati, A. (1998) · BMJ · doi:10.1136/bmj.316.7140.1275 · Cited by 443
Intestinal Decontamination for Control of Nosocomial Multiresistant Gram-Negative Bacilli
Brun‐Buisson, C., Legrand, P., Rauss, A., Richard, C., Montravers, F., Besbes, M., Meakins, J. L., Soussy, C. J., & Lemaire, F. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-11-873 · Cited by 370
A Controlled Trial in Intensive Care Units of Selective Decontamination of the Digestive Tract with Nonabsorbable Antibiotics
Gastinne, H., Wolff, M., Delatour, F., Faurisson, F., & Chevret, S. (1992) · New England Journal of Medicine · doi:10.1056/nejm199202273260903 · Cited by 362
Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care
Liberati, A., D’Amico, R., Pifferi, S., Torri, V., & Brazzi, L. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000022.pub2 · Cited by 356
Prevention of Ventilator-associated Pneumonia by Oral Decontamination
Bergmans, D. C. J. J., Bonten, M. J. M., Gaillard, S., PALING, J. C., van der GEEST, S., van Tiel, F. H., Beysens, A. J. M. M., de LEEUW, P. W., & Stobberingh, E. E. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.3.2005003 · Cited by 337
Influence of Combined Intravenous and Topical Antibiotic Prophylaxis on the Incidence of Infections, Organ Dysfunctions, and Mortality in Critically Ill Surgical Patients: A Prospective, Stratified, Randomized, Double-Blind, Placebo-controlled Clinical Trial
Krueger, W. A., Lenhart, F.-P., Neeser, G., Ruckdeschel, G., Schreckhase, H., Eissner, H. J., Forst, H., Eckart, J., Peter, K., & Unertl, K. E. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2105141 · Cited by 299
Prevention of Ventilator-associated Pneumonia by Oral Decontamination
Ar, E., D-J, D., Jk, W., Riel, E., Df, N., Ca, C., Buysse, D., Ks, K., Berens, K. L., Hj, O., et al. (2001) · Cited by 281
Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia. A randomized, placebo-controlled, double-blind clinical trial
Pugin, J. (1991) · JAMA · doi:10.1001/jama.265.20.2704 · Cited by 272
Double-blind study of selective decontamination of the digestive tract in intensive care
HAMMOND, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)92422-c · Cited by 254
Prevention of colonization and infection in critically ill patients
Kerver, A. J. H., Rommes, J. H., Mevissen-Verhage, E. A. E., Hulstaert, P. F., Vos, A. K., Verhoef, J., & WITTEBOL, P. (1988) · Critical Care Medicine · doi:10.1097/00003246-198811000-00001 · Cited by 246
Prevention of severe Candida infections in nonneutropenic, high-risk, critically ill patients: a randomized, double-blind, placebo-controlled trial in patients treated by selective digestive decontamination
Garbino, J., Lew, D. P., Romand, J.-A., Hugonnet, S., Auckenthaler, R., & Pittet, D. (2002) · Intensive Care Medicine · doi:10.1007/s00134-002-1540-y · Cited by 246
Prevention of colonization and respiratory infections in long-term ventilated patients by local antimicrobial prophylaxis
Unertl, K., Ruckdeschel, G., Selbmann, H. K., Jensen, U., Forst, H., Lenhart, F. P., & Peter, K. (1987) · Intensive Care Medicine · doi:10.1007/bf00254795 · Cited by 239
Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit
Vandenbroucke‐Grauls, C. M. J. E., & Vandenbroucke, J. P. (1991) · The Lancet · doi:10.1016/0140-6736(91)91510-2 · Cited by 237
Ecological Effects of Selective Decontamination on Resistant Gram-negative Bacterial Colonization
Oostdijk, E. A. N., de Smet, A. M. G. A., Blok, H. E. M., Groen, E. S. T., van Asselt, G. J., Benus, R. F. J., Bernards, S. T., Frénay, I., Jansz, A. R., de Jongh, B. M., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200908-1210oc · Cited by 225
Selective decontamination of the digestive tract: 13 years on, what it is and what it is not
Baxby, D., van Saene, H. K. F., Stoutenbeek, C. P., & Zandstra, D. F. (1996) · Intensive Care Medicine · doi:10.1007/bf01709750 · Cited by 215
Oropharyngeal Decontamination Decreases Incidence of Ventilator-Associated Pneumonia
Pugin, J., Auckenthaler, R., Lew, D. P., & Suter, P. M. (1991) · JAMA · doi:10.1001/jama.1991.03460200084041 · Cited by 212
Randomized, controlled trial of selective digestive decontamination in 600 mechanically ventilated patients in a multidisciplinary intensive care unit
Verwaest, C., Verhaegen, J., Ferdinande, P., Schetz, M., den Berghe, G. V., VERBIST, L., & Lauwers, P. (1997) · Critical Care Medicine · doi:10.1097/00003246-199701000-00014 · Cited by 208
Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials
Silvestri, L., van Saene, H. K. F., Milanese, M., Gregori, D., & Gullo, A. (2007) · Journal of Hospital Infection · doi:10.1016/j.jhin.2006.10.014 · Cited by 208
Self-citation
Prospective controlled trial of selective parenteral and enteral antimicrobial regimen in fulminant liver failure
Rolando, N., Gimson, A. E., Wade, J. J., Philpott‐Howard, J., Casewell, M., & Williams, R. L. (1993) · Hepatology · doi:10.1002/hep.1840170206 · Cited by 204
The Effect of Oropharyngeal Decontamination Using Topical Nonabsorbable Antibiotics on the Incidence of Nosocomial Respiratory Tract Infections in Multiple Trauma Patients
Stoutenbeek, C. P., SAENE, H. K. F. V., Miranda, D. R., DURK, F., & Langrehr, D. (1987) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198704000-00003 · Cited by 201
Effectiveness and Cost of Selective Decontamination of the Digestive Tract in Critically Ill Intubated Patients: A Randomized, Double-blind, Placebo-controlled, Multicenter Trial
García, M. S., Galache, J. A. C., DIAZ, J. L., Cerdá, E., BLASCO, J. R., AGUINAGA, M. A. G., Reiz, A. N., MARÍN, S. R., Cañaveral, J. J. O., & del CASTILLO, J. A. S. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.3.9712079 · Cited by 199
Survival Benefit in Critically Ill Burned Patients Receiving Selective Decontamination of the Digestive Tract
de la Cal, M. A., Cerdá, E., García-Hierro, P., van Saene, H. K. F., Gómez-Santos, D., Negro, E., & Lorente, J. A. (2005) · Annals of Surgery · doi:10.1097/01.sla.0000154148.58154.d5 · Cited by 192
Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care
D’Amico, R., Pifferi, S., Torri, V., Brazzi, L., Parmelli, E., & Liberati, A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000022.pub3 · Cited by 190
Selective decontamination of the digestive tract with norfloxacin in the prevention of ICU-acquired infections: a prospective randomized study
Ulrich, C., Weerd, J. E. H.-D., Bakker, N. C., Jacz, K., Doornbos, L., & de Ridder, V. A. (1989) · Intensive Care Medicine · doi:10.1007/bf00255597 · Cited by 187
SOME LABORATORY AND CLINICAL EXPERIENCES WITH A NEW ANTIBIOTIC, VANCOMYCIN
GERACI, J. E., Heilman, F. R., Nichols, D. R., Wellman, W. E., & Ross, G. T. (1956) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(26)01926-9 · Cited by 184
Selective digestive tract decontamination and selective oropharyngeal decontamination and antibiotic resistance in patients in intensive-care units: an open-label, clustered group-randomised, crossover study
de Smet, A. M. G. A., Kluytmans, J. A. J. W., Blok, H. E. M., Mascini, E. M., Benus, R. F. J., Bernards, A. T., Kuijper, E. J., Hall, M. A. L., Jansz, A. R., de Jongh, B. M., et al. (2011) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70035-4 · Cited by 183
A Randomized, Double-Blind, Placebo-Controlled Trial of Selective Digestive Decontamination Using Oral Gentamicin and Oral Polymyxin E for Eradication of Carbapenem-Resistant Klebsiella pneumoniae Carriage
Saidel‐Odes, L., Polachek, H., Peled, N., Riesenberg, K., Schlaeffer, F., Trabelsi, Y., Eskira, S., Yousef, B., Smolykov, R., Codish, S., et al. (2011) · Infection Control and Hospital Epidemiology · doi:10.1086/663206 · Cited by 182
Prevention of nosocomial lung infection in ventilated patients
Rodriguez-Roldan, J. M., ALTUNA-CUESTA, A., LÓPEZ, A., Carrillo, A., García, J. P., LEÓN, J., & MARTÍNEZ-PELLUS, A. J. (1990) · Critical Care Medicine · doi:10.1097/00003246-199011000-00011 · Cited by 166
HR 756, a New Cephalosporin Active Against Gram-Positive and Gram-Negative Aerobic and Anaerobic Bacteria
Neu, H. C., Aswapokee, N., Aswapokee, P., & Fu, K. P. (1979) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.15.2.273 · Cited by 157
Decrease in nosocomial pneumonia in ventilated patients by selective oropharyngeal decontamination (SOD)
Abele‐Horn, M., Dauber, A., Bauernfeind, A., Russwurm, W., Seyfarth-Metzger, I., Gleich, P., & Ruckdeschel, G. (1997) · Intensive Care Medicine · doi:10.1007/s001340050314 · Cited by 154
Prevention of nosocomial infection in critically ill patients by selective decontamination of the digestive tract
Rocha, L. Á., Martin, M. J., Pita, S., Paz, J., Seco, C., Margusino, L., Villanueva, R., & Durán-Valle, M. T. (1992) · Intensive Care Medicine · doi:10.1007/bf01694341 · Cited by 151
Prospective controlled trial of selective parenteral and enteral antimicrobial regimen in fulminant liver failure
Rolando, N. (1993) · Hepatology · doi:10.1016/0270-9139(93)90076-y · Cited by 149
Selective decontamination of the digestive tract in neurosurgical intensive care unit patients
Korinek, A. M., LAISNE, M. J., Nicolas, M. H., Raskine, L., DEROIN, V., & Pors, M.-J. S.-L. (1993) · Critical Care Medicine · doi:10.1097/00003246-199310000-00013 · Cited by 144
Utility of Selective Digestive Decontamination in Mechanically Ventilated Patients
Ferrer, M., Torres, A., Gonzalez, J., de la Bellacasa, J. P., El-Ebiary, M., Roca, M., Gatell, J. M., & Rodriguez‐Roisin, R. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-120-5-199403010-00006 · Cited by 142
Prevention of Infection in Critically Ill Patients by Selective Decontamination of the Digestive Tract
Cockerill, F. R., Muller, S. R., Anhalt, J. P., Marsh, H. W., Farnell, M. B., Mucha, P., Gillespie, D. J., Ilstrup, D. M., Larson-Keller, J. J., & Thompson, R. L. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-7-545 · Cited by 142
Selective Gut Decontamination Reduces Nosocomial Infections and Length of Stay but Not Mortality or Organ Failure in Surgical Intensive Care Unit Patients
Cerra, F. B. (1992) · Archives of Surgery · doi:10.1001/archsurg.1992.01420020045007 · Cited by 141
The Prevention of Anastomotic Leakage After Total Gastrectomy with Local Decontamination
Schardey, H. M., Joosten, U., Finke, U., Staubach, K.-H., Schauer, R. J., Heiss, A., Kooistra, A., Rau, H. G., Nibler, R., Lüdeling, S., et al. (1997) · Annals of Surgery · doi:10.1097/00000658-199702000-00005 · Cited by 141
Selective decontamination of the digestive tract: a stratified, randomized, prospective study in a mixed intensive care unit.
Blair, P. H., Rowlands, B. J., Lowry, K. G., Webb, H., Armstrong, P., & Smilie, J. (1991) · PubMed · Cited by 135
Selective decontamination to reduce gram-negative colonisation and infections after oesophageal resection
Tetteroo, G. W. M., Castelein, A., Tilanus, H. W., İnce, C., Bruining, H. A., & Wagenvoort, J. H. T. (1990) · The Lancet · doi:10.1016/0140-6736(90)90813-k · Cited by 125
Can selective digestive decontamination avoid the endotoxemia and cytokine activation promoted by cardiopulmonary bypass?
Martinez-Pellús, A., Merino, P., Bru, M., Conejero, R., Seller, G., Muñoz, C., Fuentes, T., González, G., & Alvarez, B. (1993) · Critical Care Medicine · doi:10.1097/00003246-199311000-00017 · Cited by 124
Role of Gastric Colonization in Nosocomial Infections and Endotoxemia: A Prospective Study in Neurosurgical Patients on Mechanical Ventilation
Reusser, P., Zimmerli, W., Scheidegger, D. H., Marbet, G. A., Buser, M. W., & Gyr, K. E. (1989) · The Journal of Infectious Diseases · doi:10.1093/infdis/160.3.414 · Cited by 124
Effectiveness and safety of enteral vancomycin to control endemicity of methicillin-resistant Staphylococcus aureus in a medical/surgical intensive care unit
de la Cal, M. A., Cerdá, E., SAENE, H. K. F. V., García-Hierro, P., Negro, E., Parra, M. L., Arias-Rivera, S., & Ballesteros, D. (2004) · Journal of Hospital Infection · doi:10.1016/j.jhin.2003.09.021 · Cited by 121
Selective Decontamination of the Digestive Tract in Multiple Trauma Patients
Quinio, B., Albanèse, J., Bues-Charbit, M., Viviand, X., & Martin, C. (1996) · CHEST Journal · doi:10.1378/chest.109.3.765 · Cited by 114
Descontaminación selectiva
Alexis Diomedi, P. (2009) · Revista chilena de infectología · doi:10.4067/s0716-10182009000700016 · Cited by 113
The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: A systematic review and meta-analysis†
Safdar, N., Said, A., & Lucey, M. R. (2004) · Liver Transplantation · doi:10.1002/lt.20108 · Cited by 112
Selective Intestinal Decontamination in Advanced Chronic Heart Failure: A Pilot Trial
Conraads, V. M., Jorens, P. G., Clerck, L. S. D., van Saene, H. K., Ieven, M. M., Bosmans, J. M., Schuerwegh, A. J., Bridts, C. H., Wuyts, F. L., Stevens, W. J., et al. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2003.12.004 · Cited by 110
A randomized, prospective, double-blinded evaluation of selective bowel decontamination in liver transplantation
Hellinger, W. C., Yao, J. D. C., Álvarez, S., Blair, J. E., Cawley, J. J., Payá, C. V., O'Brien, P. C., Spivey, J. R., Dickson, R. C., Harnois, D. M., et al. (2002) · Transplantation · doi:10.1097/00007890-200206270-00009 · Cited by 109
Randomized Controlled Trial of Selective Bowel Decontamination for Prevention of Infections Following Liver Transplantation
Arnow, P. M., Carandang, G., Zabner, R., & Irwin, M. E. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.6.997 · Cited by 107
Selective decontamination of the digestive tract reduces Gram-negative pulmonary colonization but not systemic endotoxemia in patients undergoing elective liver transplantation
Bion, J., Badger, I., Crosby, H. A., Hutchings, P., Kong, K.-L., Baker, J., Hutton, P., McMaster, P. D., Buckels, J. A. C., & Elliott, T. (1994) · Critical Care Medicine · doi:10.1097/00003246-199401000-00011 · Cited by 107
Prevention of acquired infections in intubated patients with the combination of two decontamination regimens
Camus, C., Bellissant, É., Sebille, V., Perrotin, D., Garo, B., Legras, A., Renault, A., Corre, P. L., Donnio, P.-Y., Gacouin, A., et al. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000152224.01949.01 · Cited by 106
Gastrointestinal motility disorders and bacterial overgrowth
Husebye, E. (1995) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1995.tb01196.x · Cited by 106
A controlled trial of selective decontamination of the digestive tract in intensive care and its effect on nosocomial infection
Winter, R., Humphreys, H., Pick, A., MacGowan, A. P., Willatts, S. M., & Speller, D. C. E. (1992) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/30.1.73 · Cited by 106
Antibiotic Prophylaxis of Respiratory Tract Infection in Mechanically Ventilated Patients
Aerdts, S. J. A., van Dalen, R., Clasener, H. A. L., Festen, J., van Lier, H. J. J., & Vollaard, E. J. (1991) · CHEST Journal · doi:10.1378/chest.100.3.783 · Cited by 105
A Randomized, Double-Blind, Placebo-Controlled Trial of Selective Digestive Decontamination in a Medical-Surgical Intensive Care Unit
Wiener, J., Itokazu, G. S., Nathan, C., Kabins, S. A., & Weinstein, R. A. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.4.861 · Cited by 105
Oropharyngeal flora as a source of bacteria colonizing the lower airways in patients on artificial ventilation
Uffelen, R. V., SAENE, H. K. F. V., Fidler, V., & Löwenberg, A. (1984) · Intensive Care Medicine · doi:10.1007/bf00256259 · Cited by 105
How to classify infections in intensive care units—the carrier state, a criterion whose time has come?
van Saene, H. K. F., Damjanovic, V., Murray, A. E., & de la Cal, M. A. (1996) · Journal of Hospital Infection · doi:10.1016/s0195-6701(96)90025-0 · Cited by 99
Selective decontamination of the digestive tract in severely burned pediatric patients
Barret, J. P., Jeschke, M. G., & Herndon, D. N. (2001) · Burns · doi:10.1016/s0305-4179(00)00147-9 · Cited by 99
The role of selective decontamination of the digestive tract in acute stroke
Gosney, M., Martin, M. V., & Wright, A. E. (2005) · Age and Ageing · doi:10.1093/ageing/afj019 · Cited by 98
Pilot Trial of Selective Decontamination for Prevention of Bacterial Infection in an Intensive Care Unit
Flaherty, J. P., Nathan, C., Kabins, S. A., & Weinstein, R. A. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/162.6.1393 · Cited by 97
Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia. A randomized, placebo-controlled, double-blind clinical trial.
Pugin, J., Auckenthaler, R., Lew, D. P., & Suter, P. M. (1991) · PubMed · Cited by 96
Tobramycin: An Overview
Neu, H. C. (1976) · The Journal of Infectious Diseases · doi:10.1093/infdis/134.supplement_1.s3 · Cited by 95
Endogenous endotoxemia of intestinal origin during cardiopulmonary bypass
Martínez-Pellús, A., Bru, M., Seller, G., Fuentes, T., Merino, P., Canovas, J., Sapiña, J., & Moro, J. (1997) · Intensive Care Medicine · doi:10.1007/s001340050494 · Cited by 95
Prospective study comparing the efficacy of prophylactic parenteral antimicrobials, with or without enteral decontamination, in patients with acute liver failure
Rolando, N., Wade, J. J., Stangou, A. J., Gimson, A., Wendon, J. A., Philpott‐Howard, J., Casewell, M. W., & Williams, R. L. (1996) · Liver Transplantation and Surgery · doi:10.1002/lt.500020103 · Cited by 93
Enteral vancomycin to control methicillin-resistant Staphylococcus aureus outbreak in mechanically ventilated patients
Silvestri, L., Milanese, M., Oblach, L., Fontana, F., Gregori, D., Guerra, R., & van Saene, H. K. F. (2002) · American Journal of Infection Control · doi:10.1067/mic.2002.122255 · Cited by 91
Self-citation
All great truths are iconoclastic: selective decontamination of the digestive tract moves from heresy to level 1 truth
van Saene, H. K. F., Petros, A., Ramsay, G., & Baxby, D. (2003) · Intensive Care Medicine · doi:10.1007/s00134-003-1722-2 · Cited by 91
The sins of expertness and a proposal for redemption
Sackett, D. L. (2000) · BMJ · doi:10.1136/bmj.320.7244.1283 · Cited by 89
Selective Intestinal Decontamination in Multiple Trauma Patients
Lingnau, W., Berger, J., Javorsky, F., Lejeune, P., Mutz, N., & Benzer, H. (1997) · doi:10.1097/00005373-199704000-00018 · Cited by 89
The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial
Stoutenbeek, C. P., van Saene, H. K. F., Little, R., Whitehead, A., & for the Working Group on Selective Decontamination of the Digestive Tract (2006) · Intensive Care Medicine · doi:10.1007/s00134-006-0455-4 · Cited by 88
Selective decontamination of the digestive tract to prevent postoperative infection: A randomized placebo-controlled trial in liver transplant patients
Zwaveling, J. H., Maring, J. K., KLOMPMAKER, I. J., Haagsma, E. B., Bottema, J. T., Laseur, M., Winter, H. L. J., van Enckevort, P. J., TenVergert, E. M., Metselaar, H. J., et al. (2002) · Critical Care Medicine · doi:10.1097/00003246-200206000-00004 · Cited by 88
Impact of Selective Decontamination of the Digestive Tract on Carriage and Infection Due to Gram-Negative and Gram-Positive Bacteria: A Systematic Review of Randomised Controlled Trials
Silvestri, L., van Saene, H. K. F., Casarin, A., Berlot, G., & Gullo, A. (2008) · Anaesthesia and Intensive Care · doi:10.1177/0310057x0803600304 · Cited by 85
Self-citation
Are most ICU infections really nosocomial? A prospective observational cohort study in mechanically ventilated patients
Silvestri, L., Monti‐Bragadin, C., Milanese, M., Gregori, D., Consales, C., & Gullo, A. (1999) · Journal of Hospital Infection · doi:10.1053/jhin.1998.0550 · Cited by 80
Self-citation
SELECTIVE DECONTAMINATION IN PEDIATRIC LIVER TRANSPLANTS
RANDOMIZED, A., Smith, S. D., Jackson, R., Hannakan, C., Wadowsky, R. M., Tzakis, A. G., & Rowe, M. I. (1993) · Transplantation · doi:10.1097/00007890-199306000-00018 · Cited by 80
Impact of selective decontamination of the digestive tract on multiple organ dysfunction syndrome: systematic review of randomized controlled trials
Silvestri, L., van Saene, H. K. F., Zandstra, D. F., Marshall, J. C., Gregori, D., & Gullo, A. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181d9db8c · Cited by 78
Self-citation
Prospective endoscopic study of stress erosions and ulcers in critically ill neurosurgical patients
Reusser, P., Gyr, K. E., Scheidegger, D. H., Buchmann, B., Buser, M. W., & Zimmerli, W. (1990) · Critical Care Medicine · doi:10.1097/00003246-199003000-00004 · Cited by 77
Impact of selective decontamination of the digestive tract on fungal carriage and infection: systematic review of randomized controlled trials
Silvestri, L., SAENE, H. K. F. V., Milanese, M., & Gregori, D. (2005) · Intensive Care Medicine · doi:10.1007/s00134-005-2654-9 · Cited by 73
Self-citation
Staphylococcus aureus Nasal Colonization in Patients with Cirrhosis: Prospective Assessment of Association with Infection
Chang, F. Y., Singh, N., Gayowski, T., Wagener, M. M., & Marino, I. R. (1998) · Infection Control and Hospital Epidemiology · doi:10.2307/30141373 · Cited by 72
Antibiotic restriction does not alter endemic colonization with resistant Gram-negative rods in a pediatric intensive care unit
Toltzis, P., Yamashita, T. S., Vilt, L., Green, M., Morrissey, A. B., Spinner-Block, S., & Blumer, J. L. (1998) · Critical Care Medicine · doi:10.1097/00003246-199811000-00035 · Cited by 71
Survival benefit of the full selective digestive decontamination regimen
Silvestri, L., van Saene, H. K. F., Weir, I. D., & Gullo, A. (2009) · Journal of Critical Care · doi:10.1016/j.jcrc.2008.11.005 · Cited by 69
Self-citation
The Polymyxins
Hoeprich, P. D. (1970) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)32591-3 · Cited by 69
No effect of preoperative selective gut decontamination on endotoxemia and cytokine activation during cardiopulmonary bypass: A randomized, placebo-controlled study
Bouter, H., Schippers, E., Luelmo, S., Versteegh, M., Ros, P., Guiot, H., Frölich, M., & van Dissel, J. V. (2002) · Critical Care Medicine · doi:10.1097/00003246-200201000-00006 · Cited by 67
Probiotics versus antibiotic decontamination of the digestive tract: infection and mortality
Oudhuis, G. J., Bergmans, D. C. J. J., Dormans, T. P. J., Zwaveling, J.-H., Kessels, A. G. H., Prins, M. H., Stobberingh, E. E., & Verbon, A. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-2002-6 · Cited by 66
Selective decontamination of subglottic area in mechanically ventilated patients with multiple trauma
Pneumatikos, I. A., Koulouras, V., Nathanail, C., Goe, D., & Nakos, G. (2002) · Intensive Care Medicine · doi:10.1007/s00134-002-1238-1 · Cited by 66
Endogenous endotoxemia of intestinal origin during cardiopulmonary bypass — role of type of flow and protective effect of selective digestive decontamination
Jakob, S. M., Takala, J. A., & Martínez-Pellús, A. (1998) · Intensive Care Medicine · doi:10.1007/s001340050658 · Cited by 66
Evidence for Biliary Excretion of Vancomycin into Stool during Intravenous Therapy: Potential Implications for Rectal Colonization with Vancomycin-Resistant Enterococci
Currie, B. P., & Lemos-Filho, L. B. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.11.4427-4429.2004 · Cited by 60
Prevention of nosocomial infection in a pediatric intensive care unit (PICU) through the use of selective digestive decontamination
Ruza, F., Alvarado, F., Herruzo, R., Delgado, M. A., García, S. G., Dorao, P., & Goded, F. (1998) · European Journal of Epidemiology · doi:10.1023/a:1007487330893 · Cited by 59
Secondary carriage with multi-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an adult ICU population: relationship with nosocomial infections and mortality
Garrouste-Orgeas, M., Marie, O., Rouveau, M., Villiers, S., Arlet, G., & Schlemmer, B. (1996) · Journal of Hospital Infection · doi:10.1016/s0195-6701(96)90108-5 · Cited by 57
Randomized clinical trial of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery
Roos, D., Dijksman, L. M., Straaten, H. M. O., de Wit, L. T., Gouma, D. J., & Gerhards, M. F. (2011) · British journal of surgery · doi:10.1002/bjs.7631 · Cited by 55
Long-term use of selective decontamination of the digestive tract does not increase antibiotic resistance: a 5-year prospective cohort study
Ochoa-Ardila, M. E., García-Cañas, A., Gómez-Mediavilla, K., González-Torralba, A., Alía, I., García-Hierro, P., Taylor, N., van Saene, H. K. F., & de la Cal, M. A. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2307-0 · Cited by 55
Prevention of pneumonia in an intensive care unit
Mandelli, M., Mosconi, P., LANGER, M., & Cigada, M. (1989) · Critical Care Medicine · doi:10.1097/00003246-198906000-00003 · Cited by 53
Reduction of colonization and infection rate during pediatric intensive care by selective decontamination of the digestive tract
Zobel, G., KUTTNIG, M., Grubbauer, H. M., Semmelrock, H., & Thiel, W. (1991) · Critical Care Medicine · doi:10.1097/00003246-199110000-00005 · Cited by 52
Effects of Carbapenem Exposure on the Risk for Digestive Tract Carriage of Intensive Care Unit-Endemic Carbapenem-Resistant Pseudomonas aeruginosa Strains in Critically Ill Patients
Peña, C., Guzmán, A. M., Suarez, C., Domínguez, M. Á., Tubau, F., Pujol, M., Gudiol, F., & Ariza, J. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01483-06 · Cited by 51
Topical Antibiotics on Tracheostoma Prevents Exogenous Colonization and Infection of Lower Airways in Children
Morar, P., Makura, Z. G. G., Jones, A. S., Baines, P. B., Selby, A., Hughes, J., & van Saene, R. (2000) · CHEST Journal · doi:10.1378/chest.117.2.513 · Cited by 51
Oropharyngeal decontamination with gentamicin for long-term ventilated patients on stress ulcer prophylaxis with sucralfate?
Laggner, A. N., Tryba, M., Georgopoulos, A., Lenz, K., Grimm, G., Graninger, W. B., Schneeweiss, B., & Druml, W. (1994) · PubMed · Cited by 51
Surveillance Cultures
Schimpff, S. C. (1981) · The Journal of Infectious Diseases · doi:10.1093/infdis/144.1.81 · Cited by 49
Prevention of nosocomial infection in mechanically ventilated patients: selective digestive decontamination versus sucralfate
Palomar, M., Álvarez-Lerma, F., Jordà, R., Borràs-Bermejo, B., & CATALAN STUDY GROUP OF NOSOCOMIAL P (1997) · Clinical Intensive Care · doi:10.3109/tcic.8.5.228.235 · Cited by 47
Antibiotic Prophylaxis in Cancer Patients: Regimens of Oral, Nonabsorbable Antibiotics for Prevention of Infection During Induction of Remission
Bodey, G. P. (1981) · Clinical Infectious Diseases · doi:10.1093/clinids/3.supplement_2.s259 · Cited by 46
A prospective study of septicaemia on a paediatric oncology unit: A three-year experience at The Royal Liverpool Children’s Hospital, Alder Hey, UK
Paulus, S. C., van Saene, H. K. F., Hemsworth, S., Hughes, J., Ng, A. Y. L., & Pizer, B. L. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.04.037 · Cited by 43
Microbial Gut Overgrowth Guarantees Increased Spontaneous Mutation Leading to Polyclonality and Antibiotic Resistance in the Critically Ill
van Saene, H., Taylor, N. F., Damjanovic, V., & Sarginson, R. E. (2008) · Current Drug Targets · doi:10.2174/138945008784221189 · Cited by 43
Efficacy of enteral decontamination in the prevention of anastomotic dehiscence and pulmonary infection in esophagogastric surgery
Farràn, L., Llop, J., Sans, M., Kreisler, E., Miró, M., Galán, M., & Rafecas, A. (2007) · Diseases of the Esophagus · doi:10.1111/j.1442-2050.2007.00764.x · Cited by 39
Selective decontamination
SAENE, H. K. F. V., & Stoutenbeek, C. P. (1987) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/20.4.462 · Cited by 39
Influence of Prophylactic Probiotics and Selective Decontamination on Bacterial Translocation in Patients Undergoing Pancreatic Surgery
Diepenhorst, G. M. P., van Ruler, O., Besselink, M. G., van Santvoort, H. C., Wijnandts, P. R., Renooij, W., Gouma, D. J., Gooszen, H. G., & Boermeester, M. A. (2010) · Shock · doi:10.1097/shk.0b013e3181ed8f17 · Cited by 38
Randomized clinical trial of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery
Behrns, K. E. (2012) · Yearbook of Surgery · doi:10.1016/j.ysur.2012.02.015 · Cited by 38
Levels of Cefotaxime in Body Fluids and Tissues: A Review
Novick, W. J. (1982) · Clinical Infectious Diseases · doi:10.1093/clinids/4.supplement_2.s346 · Cited by 38
Biliary Concentrations of Fluconazole in a Patient with Candidat Cholecystitis: Case Report
Bozzette, S. A., Gordon, R. L., Yen, A., Rinaldi, M. G., Ito, M. K., & Fierer, J. (1992) · Clinical Infectious Diseases · doi:10.1093/clind/15.4.701 · Cited by 37
Concentrations of amphotericin B in faeces and blood of healthy volunteers after the oral administration of various doses
Hofstra, W., de Vries-Hospers, H. G., & van der Waaij, D. (1982) · Infection · doi:10.1007/bf01666915 · Cited by 36
Reduction of the intestinal endotoxin pool by three different SDD regimens in human volunteers
Saene, J. J. M. V., Stoutenbeek, C. P., SAENE, H. K. F. V., Matera, G., Martínez-Pellús, A., & Ramsay, G. (1996) · Journal of Endotoxin Research · doi:10.1177/096805199600300408 · Cited by 34
Selective decontamination of the digestive tract does not increase resistance in critically ill patients: Evidence from randomized controlled trials
Silvestri, L., & van Saene, H. K. F. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000226400.53640.99 · Cited by 34
Self-citation
Gastric Flora in Chronically Mechanically Ventilated Patients: Relationship to Upper and Lower Airway Colonization
Palmer, L. B., Donelan, S. V., Fox, G., Bellemore, E., & Greene, W. H. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.151.4.7697232 · Cited by 34
Low dose oral tobramycin treatment for selective decontamination of the digestive tract: a study in human volunteers
Mulder, J., Wiersma, W. E., Welling, G. W., & van der Waaij, D. (1984) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/13.5.495 · Cited by 32
Concentrations of nystatin in faeces after oral administration of various doses of nystatin
Hofstra, W., de Vries-Hospers, H. G., & van der Waaij, D. (1979) · Infection · doi:10.1007/bf01640934 · Cited by 31
Welkommen to Our World: Emergence of Antibiotic Resistance with Selective Decontamination of the Digestive Tract
Wunderink, R. G. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1821ed · Cited by 31
Effect of selective decontamination on antibiotic resistance
Vincent, J., & Jacobs, F. (2011) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70067-6 · Cited by 28
Selective Decontamination of the Digestive Tract Contributes to the Control of Disseminated Intravascular Coagulation in Severe Liver Impairment
van Saene, H. K. F., Stoutenbeek, C. P., Faber‐Nijholt, R., & Saene, J. J. M. V. (1992) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199205000-00011 · Cited by 28
Differing Pathways of Lower Airway Colonization and Infection According to Mode of Ventilation (Endotracheal vs Tracheotomy)
Morar, P., Singh, V., Makura, Z. G. G., Jones, A. S., Baines, P. B., Selby, A., Sarginson, R. E., Hughes, J., & van Saene, R. (2002) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.128.9.1061 · Cited by 27
Effect of Amoxycillin on Colonisation Resistance in Human Volunteers
SAENE, H. K. F. V., Stoutenbeek, C. P., Geitz, J. N., Saene, J. J. M. V., & Hart, C. A. (1988) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v1i3.7412 · Cited by 27
Is Selective Digestive Decontamination Useful in Controlling Aerobic Gram-Negative Bacilli Producing Extended Spectrum Beta-Lactamases?
Abecasis, F., Sarginson, R. E., Kerr, S. J., Taylor, N., & SAENE, H. K. F. V. (2011) · Microbial Drug Resistance · doi:10.1089/mdr.2010.0060 · Cited by 26
Décontamination Digestive Sélective Résultats D'une Étude Chez Le Polytraumatisé
Georges, B., Mazerolles, M., Decun, J. F., Rouge, P., Pomiès, S., Cougot, P., Andrieu, P., & Virenque, C. (1994) · Réanimation Urgences · doi:10.1016/s1164-6756(05)80459-1 · Cited by 26
The Role of Admission Surveillance Cultures in Patients Requiring Prolonged Mechanical Ventilation in the Intensive Care Unit
Viviani, M., van Saene, H. K. F., Pisa, F. E., Lucangelo, U., Silvestri, L., Momesso, E., & Berlot, G. (2010) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1003800215 · Cited by 26
Self-citation
TREATMENT OF SALMONELLA CARRIERS WITH COLISTIN SULFATE
Gotoff, S. P., Lepper, M. H., & FIEDLER, M. A. (1965) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196504000-00005 · Cited by 24
Enterobacteriaceae suppression by three different oral doses of polymyxin E in human volunteers
Saene, J. J. M. V., SAENE, H. K. F. V., Tarko-Smit, N. J. P. H., & Beukeveld, G. J. J. (1988) · Epidemiology and Infection · doi:10.1017/s0950268800067169 · Cited by 21
The effect of amphotericin B on the fungal flora in feces
Bodey, G. P. (1969) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1969105675 · Cited by 19
SDD, SOD, or oropharyngeal chlorhexidine to prevent pneumonia and to reduce mortality in ventilated patients: which manoeuvre is evidence-based?
Silvestri, L., van Saene, H. K. F., Zandstra, D. F., Viviani, M., & Gregori, D. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-1809-5 · Cited by 18
Self-citation
Protected Environment — Prophylactic Antibiotic Programmes; Microbiological Studies
Bodey, G. P., & Rodriguez, V. (1976) · Clinics in Haematology · doi:10.1016/s0308-2261(21)00032-1 · Cited by 17
Is There a Role for Selective Decontamination of the Digestive Tract in Primarily Infected Patients in the ICU?
Hammond, J., & Potgieter, P. D. (1995) · Anaesthesia and Intensive Care · doi:10.1177/0310057x9502300240 · Cited by 17
Selective Digestive Tract Decontamination: A Tough Pill to Swallow
Laupland, K. B., & Fisman, D. N. (2009) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2009/290130 · Cited by 16
Selective Decontamination of the Digestive Tract in Burn Patients: An Evidence-Based Maneuver That Reduces Mortality
Silvestri, L., de la Cal, M. A., Taylor, N., van Saene, H. K. F., & Parodi, P. C. (2010) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181d1b61f · Cited by 13
Self-citation
Reducing susceptibility to bacteremia after experimental burn injury: a role for selective decontamination of the digestive tract
Horton, J. W., Maass, D. L., White, J., & Minei, J. P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01365.2005 · Cited by 11
Descontaminación digestiva selectiva
Fernández, E. M., García, N. R. D. E., Echevarria, B. C., & González, C. M. (2003) · Enfermería Intensiva · doi:10.1016/s1130-2399(03)78112-7 · Cited by 10
Selective digestive decontamination reduces ventilator-associated tracheobronchitis
Silvestri, L., Milanese, M., Taylor, N., Piacente, N., Zandstra, D. F., & van Saene, H. K. F. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2010.05.023 · Cited by 9
Self-citation
Selective digestive decontamination. Why are intensivists more "resistant" than microorganisms?
Silvestri, L., Petros, A., Cal, M. A. D. L., & Visintin, S. (2011) · PubMed · Cited by 9
Self-citation
Gut overgrowth harms the critically ill
Petros, A., Taylor, N., van Saene, H. K., & Silvestri, L. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2287-0 · Cited by 8
Self-citation
Selective digestive decontamination and antibiotic resistance
Bion, J., Taylor, N. F., Petros, A., Silvestri, L., & van Saene, H. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70276-6 · Cited by 6
Self-citation
Selective Decontamination of the Digestive Tract (SDD). Twenty-five Years of European Experience
Silvestri, L., de la Cal, M. A., & SAENE, H. K. F. V. (2009) · Springer eBooks · doi:10.1007/978-88-470-1436-7_23 · Cited by 6
Self-citation
Combinations of antimicrobial agents. I. The in vitro sensitivity of 100 strains of Pseudomonas aeruginosa to polymyxin B, colistin, carbenicillin, gentamicin and doxycycline and to various combinations of these antibiotics.
Js, K. (1975) · PubMed · Cited by 5
Effects of preoperatively selected gut decontamination on cardiopulmonary bypass-induced endotoxemia.
Jiang, Y., Xiao, Y., & Wang, X. (2007) · PubMed · Cited by 5
Worlds Apart: Proof that SDD Works
Wunderink, R. G. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.182.12.1564a · Cited by 4
Prevention of Pneumonia in an Intensive Care Unit
Stoutenbeek, H. P. (1990) · Critical Care Medicine · doi:10.1097/00003246-199010000-00038 · Cited by 4
[Excretion of beta-lactam antibiotics in human parotid saliva].
Maier, H., Zerfowski, M., & Schlegel, P. (1991) · PubMed · Cited by 4
Treatment of sepsis
van Saene, H. K., Silvestri, L., Taylor, N., Petros, A., & Bion, J. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70230-x · Cited by 4
Self-citation
Worlds Apart: Proof that SDD Works
Petros, A., Taylor, N., Damjanovic, V., van Saene, H. K., Abecasis, F., Silvestri, L., & de la Cal, M. A. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.182.12.1564 · Cited by 4
Self-citation
Selective Digestive Decontamination can be an Infection-Prevention Regimen for the Intoxicated Patients
Yılmazlar, A., Özyurt, G., Kahveci, F., & Göral, G. (2008) · Journal of Pharmacology and Toxicology · doi:10.3923/jpt.2009.36.40 · Cited by 3
Selective digestive decontamination reduces bacteremia following eradication of gut overgrowth
Silvestri, L., Petros, A., Zandstra, D. F., Taylor, N., & van Saene, H. K. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e31822d21b8 · Cited by 2
Self-citation
Selective Decontamination of the Digestive Tract May Reinforce the Efficacy of Corticosteroids
Silvestri, L., Rommes, J. H., Petros, A., Taylor, N., & van Saene, H. K. F. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.185.3.344 · Cited by 2
Self-citation
Selective decontamination and ecology
van Saene, H. K. F., Taylor, N., Silvestri, L., de la Cal, M. A., Petros, A., & Zandstra, D. F. (2012) · Anaerobe · doi:10.1016/j.anaerobe.2012.02.001 · Cited by 1
Self-citation
Gravity may be the law, but it does not impact critical illness related carriage in overgrowth.
Silvestri, L., Zandstra, D. F., Petros, A., Taylor, N., & Hk, V. S. (2012) · PubMed · Cited by 1
Self-citation

Research works printed but not linked: 6

Abdel-Razek SM, Abdel-Khalek AH, Allam AM, Shalaby H, Mandoor S, Higazi M (2000) Impact of selective gastrointestinal decontamination on mortality and morbidity in severely burned patients. Ann Burns Fire Disast 13:213–216
Gaussorgues PH, Salord F, Sirodot M, Tigaud S, Cagin S, Gerard M, Robert D (1991) Efficacite de la decontamination digestive sur la survenue des bacteriemies nosocomiales chez les patients sous ventilation mecanique et recevant des betamimetiques. Rean Soins Intens Med Urg 7:169–174
Jacobs S, Foweraker JE, Roberts SE (1992) Effectiveness of selective decontamination of the digestive tract (SDD) in an ICU with a policy encouraging a low gastric pH. Clin Intensive Care 3:52–58
van Saene HKF, Stoutenbeek CP, Geitz JN, van Saene JJM, Hart CA (1988) Effect of amoxicillin on colonization resistance in human volunteers. Microb Ecol Health Dis 1:169–177
Bodey GP, Pan T (1980) Absorption of tobramycin after chronic oral administration. Curr Ther Res 28:394–401
Palmer LB, Donelan SV, Fox G, Bellemore E, Greene WH (1995) Gastric flora in chronically mechanically ventilated patients. Am J Respir Crit Care Med 151:1063–1067

Sorted by citations

Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome
Dickson, R. P., Singer, B. H., Newstead, M. W., Falkowski, N. R., Erb-Downward, J. R., Standiford, T. J., & Huffnagle, G. B. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.113 · Cited by 724
The microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460
The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness
Klingensmith, N. J., & Coopersmith, C. M. (2016) · Critical Care Clinics · doi:10.1016/j.ccc.2015.11.004 · Cited by 429
How should we respond to the emergence of plasmid-mediated colistin resistance in humans and animals?
Al‐Tawfiq, J. A., Laxminarayan, R., & Mendelson, M. (2016) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2016.11.415 · Cited by 142
Randomized clinical trial of selective decontamination of the digestive tract in elective colorectal cancer surgery (SELECT trial)
Abis, G. S. A., Stockmann, H. B. A. C., Bonjer, H. J., van Veenendaal, N., van Doorn-Schepens, M. L. M., Budding, A. E., Wilschut, J. A., van Egmond, M., Oosterling, S. J., Abis, G. S. A., et al. (2019) · British journal of surgery · doi:10.1002/bjs.11117 · Cited by 113

See all 111

Authors: Silvestri, L., de la Cal, M. A., & van Saene, H. K. F.
Venue: Intensive Care Medicine
Publisher: Springer Science and Business Media LLC
Published: 2012-09-22
Volume: 38
Issue: 11
Pages: 1738-1750
ISSN: 0342-4642 (ISSN-L)
1432-1238
DOI: 10.1007/s00134-012-2690-1
OpenAlex: W2065187449
Cited by: 111
References: 156
Citations by year: 2026: 4 · 2025: 7 · 2024: 6 · 2023: 12 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 12 · 2013: 16
FWCI: 1.88
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Intensive Care Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords: selective decontamination of the digestive tract, critically ill patients, antibiotic prophylaxis, lower respiratory tract infection, bloodstream infection, mortality, antimicrobial resistance, cefotaxime, polymyxins, tobramycin, vancomycin, methicillin-resistant Staphylococcus aureus, Candida, Staphylococcus aureus, endogenous infection
MeSH terms: Bacterial Infections, Carrier State, Decontamination, Digestive System, Gram-Negative Aerobic Bacteria, Humans, Meta-Analysis as Topic, Randomized Controlled Trials as Topic, Critical Illness, Antibiotic Prophylaxis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Selective decontamination of the digestive tract: the mechanism of action is control of gut overgrowth

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks