The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Short-course antibiotic therapy for critically ill patients treated for postoperative intra-abdominal infection: The DURAPOP randomised clinical trial.
Open accessAbstract
Purpose Shortening the duration of antibiotic therapy (ABT) is a key measure in antimicrobial stewardship. The optimal duration of ABT for treatment of postoperative intra-abdominal infections (PIAI) in critically ill patients is unknown.Methods A multicentre prospective randomised trial conducted in 21 French intensive care units (ICU) between May 2011 and February 2015 compared the efficacy and safety of 8-day versus 15-day antibiotic therapy in critically ill patients with PIAI. Among 410 eligible patients (adequate source control and ABT on day 0), 249 patients were randomly assigned on day 8 to either stop ABT immediately (n = 126) or to continue ABT until day 15 (n = 123). The primary endpoint was the number of antibiotic-free days between randomisation (day 8) and day 28. Secondary outcomes were death, ICU and hospital length of stay, emergence of multidrug-resistant (MDR) bacteria and reoperation rate, with 45-day follow-up.Results Patients treated for 8 days had a higher median number of antibiotic-free days than those treated for 15 days (15 [6-20] vs 12 [6-13] days, respectively; P < 0.0001) (Wilcoxon rank difference 4.99 days [95% CI 2.99-6.00; P < 0.0001). Equivalence was established in terms of 45-day mortality (rate difference 0.038, 95% CI - 0.013 to 0.061). Treatments did not differ in terms of ICU and hospital length of stay, emergence of MDR bacteria or reoperation rate, while subsequent drainages between day 8 and day 45 were observed following short-course ABT (P = 0.041).Conclusion Short-course antibiotic therapy in critically ill ICU patients with PIAI reduces antibiotic exposure. Continuation of treatment until day 15 is not associated with any clinical benefit. CLINICALTRIALS.Gov identifier NCT01311765.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Intra-abdominal | Montravers 2018 (305) | 8 days | 15 days | No difference”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as Montravers 2018 (305)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Magiorakos, A.-P., Srinivasan, A., Carey, R. B., Carmeli, Y., Falagas, M. E., Giske, C. G., Harbarth, S., Hindler, J. F., Kahlmeter, G., Olsson-Liljequist, B., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03570.x · Cited by 14,449
mice: Multivariate Imputation by Chained Equations in R
Buuren, S. V., & Groothuis-Oudshoorn, K. (2011) · Journal of Statistical Software · doi:10.18637/jss.v045.i03 · Cited by 13,870
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
Le Gall, J.-R. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.270.24.2957 · Cited by 7,773
J Antimicrob Chemother 1994; 33: 350–351
O’Shaughnessy, E. M., & DAS, S. S. (1994) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/33.2.350 · Cited by 3,758
Barlam, T. F., Cosgrove, S. E., Abbo, L. M., MacDougall, C., Schuetz, A. N., Septimus, E. J., Srinivasan, A., Dellit, T. H., Falck-Ytter, Y. T., Fishman, N. O., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw118 · Cited by 3,214
Solomkin, J. S., Mazuski, J. E., Bradley, J. S., Rodvold, K. A., Goldstein, E. J. C., Baron, E. J., O’Neill, P. J., Chow, A. W., Dellinger, E. P., Eachempati, S. R., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/649554 · Cited by 1,571
Chastre, J., Wolff, M., Fagon, J.-Y., Chevret, S., Thomas, F., Wermert, D., Clementi, E., Gonzalez, J., Jusserand, D., Asfar, P., et al. (2003) · JAMA · doi:10.1001/jama.290.19.2588 · Cited by 1,376
Self-citationBouadma, L., Luyt, C.-E., Tubach, F., Cracco, C., Alvarez, A., Schwebel, C., Schortgen, F., Lasocki, S., Veber, B., Dehoux, M., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61879-1 · Cited by 1,183
Self-citationGoldmann, D. A. (1996) · JAMA · doi:10.1001/jama.1996.03530270074035 · Cited by 755
Trial of short-course antimicrobial therapy for intraabdominal infection.
Sawyer, R. G., Claridge, J. A., Nathens, A. B., Rotstein, O. D., Duane, T. M., Evans, H. L., Cook, C. H., O’Neill, P. J., Mazuski, J. E., Askari, R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411162 · Cited by 747
The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection
Mazuski, J. E., Tessier, J. M., May, A. K., Sawyer, R. G., Nadler, E. P., Rosengart, M. R., Chang, P. K., O’Neill, P. J., Mollen, K. P., Huston, J. M., et al. (2017) · Surgical Infections · doi:10.1089/sur.2016.261 · Cited by 604
Solomkin, J. S., Hershberger, E., Miller, B. W., Popejoy, M. W., Friedland, I. R., Steenbergen, J. N., Yoon, M., Collins, S. H., Yuan, G., Barie, P. S., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ097 · Cited by 423
Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR)
Evans, S. R., Rubin, D., Follmann, D. A., Pennello, G. A., Huskins, W. C., Powers, J. H., Schoenfeld, D., Chuang‐Stein, C., Cosgrove, S. E., Fowler, V. G., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ495 · Cited by 363
Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study
Sartelli, M., Catena, F., Ansaloni, L., Coccolini, F., Corbella, D., Moore, E. E., Malangoni, M. A., Velmahos, G. C., Coimbra, R. S. M., Koike, K., et al. (2014) · World Journal of Emergency Surgery · doi:10.1186/1749-7922-9-37 · Cited by 311
LUCASTI, C. J., Popescu, I., Ramesh, M. K., Lipka, J., & Sable, C. A. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks523 · Cited by 234
Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference
Sartelli, M., Catena, F., Abu‐Zidan, F. M., Ansaloni, L., Biffl, W. L., Boermeester, M. A., Ceresoli, M., Chiara, O., Coccolini, F., Waele, J. J. D., et al. (2017) · World Journal of Emergency Surgery · doi:10.1186/s13017-017-0132-7 · Cited by 222
Self-citationGuidelines for management of intra-abdominal infections
Montravers, P., Dupont, H., Léone, M., Constantin, J., Mertès, P., Laterre, P., Misset, B., Bru, J. P., Gauzit, R., Sotto, A., et al. (2015) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2015.03.005 · Cited by 160
Self-citationfor the EPIC II Investigators, Waele, J. J. D., Lipman, J., Sakr, Y. L., Marshall, J. C., Vanhems, P., Groba, C. B., Léone, M., & Vincent, J. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-420 · Cited by 138
Solomkin, J. S., Ramesh, M. K., Česnauskas, G., Novikovs, N., Stefanova, P. P., Sutcliffe, J. A., Walpole, S. M., & Horn, P. T. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01614-13 · Cited by 120
Riché, F. C., Dray, X., Laisné, M.-J. C., Matéo, J., Raskine, L., Pors, M.-J. S.-L., Payen, D. M., Valleur, P. D., & Cholley, B. (2009) · Critical Care · doi:10.1186/cc7931 · Cited by 118
Antibiotic Duration After Laparoscopic Appendectomy for Acute Complicated Appendicitis
van Rossem, C. C., Schreinemacher, M. H. F., van Geloven, A. A. W., Bemelman, W. A., & for the Snapshot Appendicitis Collaborative Study Group (2015) · JAMA Surgery · doi:10.1001/jamasurg.2015.4236 · Cited by 99
Self-citationDupont, H., Friggeri, A., Touzeau, J., Airapetian, N., Tinturier, F., Lobjoie, E., Lorne, E., Hijazi, M., Regimbeau, J., & Mahjoub, Y. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr308 · Cited by 91
Self-citationSéguin, P., Laviolle, B., Chanavaz, C., Donnio, P.-Y., Gautier-Lerestif, A.-L., Campion, J. P., & Mallédant, Y. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01507.x · Cited by 80
Séguin, P., Fédun, Y., Laviolle, B., Nesseler, N., Donnio, P.-Y., & Mallédant, Y. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp439 · Cited by 76
Canadian Practice Guidelines for Surgical Intra‐Abdominal Infections
Chow, A. W., Evans, G. A., Nathens, A. B., Ball, C. G., Hansen, G. T., Harding, G., Kirkpatrick, A. W., Weiss, K., & Zhanel, G. G. (2010) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2010/580340 · Cited by 58
Montravers, P., Augustin, P., Grall, N., Desmard, M., Allou, N., Marmuse, J., & Guglielminotti, J. R. (2016) · Critical Care · doi:10.1186/s13054-016-1267-8 · Cited by 55
Self-citationDynamic changes of microbial flora and therapeutic consequences in persistent peritonitis
Montravers, P., Dufour, G., Guglielminotti, J. R., Desmard, M., Muller‐Serieys, C., Houissa, H., Allou, N., Marmuse, J., & Augustin, P. (2015) · Critical Care · doi:10.1186/s13054-015-0789-9 · Cited by 54
Self-citationJung, B., Molinari, N., Nasri, M., Hajjej, Z., Chanques, G., Jean‐Pierre, H., Panaro, F., & Jaber, S. (2013) · Critical Care · doi:10.1186/cc13082 · Cited by 45
Self-citationPseudomonas aeruginosa Post-Operative Peritonitis: Clinical Features, Risk Factors, and Prognosis
Augustin, P., Tran‐Dinh, A., Valin, N., Desmard, M., Crevecoeur, M. A., Muller‐Serieys, C., Woerther, P., Marmuse, J., Bronchard, R., & Montravers, P. (2013) · Surgical Infections · doi:10.1089/sur.2012.084 · Cited by 20
Self-citationAntibiotikatherapie intraabdomineller Infektionen im Zeitalter der Multiresistenz
Eckmann, C. (2015) · Der Chirurg · doi:10.1007/s00104-015-0106-9 · Cited by 19
Waele, J. J. D., Tellado, J. M., Weiß, G., Alder, J. D., Kruesmann, F., Arvis, P., Hussain, T., & Solomkin, J. S. (2014) · Surgical Infections · doi:10.1089/sur.2013.045 · Cited by 7
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935
Bloodstream infections in critically ill patients: an expert statement
Timsit, J., Ruppé, É., Barbier, F., Tabah, A., & Bassetti, M. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05950-6 · Cited by 487
2023 Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency Department
Guarino, M., Perna, B., Cesaro, A. E., Maritati, M., Spampinato, M. D., Contini, C., & GIORGIO, R. D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093188 · Cited by 342
How to use biomarkers of infection or sepsis at the bedside: guide to clinicians
Póvoa, P. M. S. R., Coelho, L., Dal‐Pizzol, F., Ferrer, R., Huttner, A., Morris, A. C., Junior, V. A. N., Ramírez, P., Rouzé, A., Salluh, J. I., et al. (2023) · Intensive Care Medicine · doi:10.1007/s00134-022-06956-y · Cited by 313
Metadata
- Authors
- For the DURAPOP Trial Group, Montravers, P., Tubach, F., Lescot, T., Veber, B., Esposito-Farèse, M., Seguin, P., Paugam, C., Lepape, A., Meistelman, C., Cousson, J., Tesniere, A., Plantefeve, G., Blasco, G., Asehnoune, K., Jaber, S., Lasocki, S., & Dupont, H.
- Affiliations
- Assistance Publique – Hôpitaux de Paris (FR)
- Inserm (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Centre Hospitalier Universitaire de Besançon (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Corresponding author
- Montravers, Philippe
- ORCID
- Venue
- Intensive Care Medicine
- Published
- 2018-02-26
- Volume
- 44
- Issue
- 3
- Pages
- 300-310
- ISSN
- 0342-4642 (ISSN-L)
- 1432-1238
- OpenAlex
- W2788905391
- Semantic Scholar
- dbe977f969deb7a1c03bc9fa9985b3dc9757f50a
- Cited by
- 173
- References
- 33
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 17 · 2023: 24 · 2022: 30 · 2021: 30 · 2020: 17 · 2019: 16 · 2018: 11
- FWCI
- 11.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Intensive Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- French Ministery of Health-Programme Hospitalier de Recherche Clinique 2009 (AOM-09024)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Health Sciences › Medicine › Surgery › Surgical site infection prevention
- Health Sciences › Medicine › Surgery › Abdominal Surgery and Complications
- Keywords
- short-course antibiotic therapy, postoperative intra-abdominal infection, critically ill patients, antimicrobial stewardship, antibiotic duration, multidrug-resistant bacteria, reoperation, ICU length of stay, mortality
- MeSH terms
- Aged, Aged, 80 and over, Anti-Bacterial Agents, Female, France, Humans, Intensive Care Units, Male, Middle Aged, Obesity, Morbid, Prospective Studies, Critical Illness, Intraabdominal Infections
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
