Polypropylene mesh and the host response
Abstract
The use of polypropylene (PP) mesh for pelvic floor repair has been increasing dramatically over the past decade; however, tissue response in humans has not been extensively studied. This review discusses PP mesh and postimplantation host tissue response. Emphasis is placed on studies investigating the relationship between individual mesh properties and specific responses. There is an immediate inflammatory response after PP mesh implantation that lays the framework for tissue ingrowth and subsequent mesh integration. This response varies based on physical properties of individual mesh, such as pore size, weight, coatings, bacterial colonization, and biofilm production.
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In anti-adhesion applications, PP is often used in composite meshes where one side provides structural support and the other side, typically coated with a biodegradable or bio-inert material, prevents tissue adhesion.
“In anti-adhesion applications, PP is often used in composite meshes where one side provides structural support, while the other side, typically coated with a biodegradable or bio-inert material, prevents tissue adhesion [244].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [244]
Cites
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138 · cited 1× · see citing works
“A well-known host response to foreign-body implantation occurs immediately after introduction of the biomaterial into the body [15].”
BackgroundMast cells mediate acute inflammatory responses to implanted biomaterials
Tang, L., Jennings, T. A., & Eaton, J. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8841 · Cited by 272 · see citing works
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Patel, H., Ostergard, D. R., & Sternschuss, G.
- Affiliations
- MemorialCare Long Beach Medical Center (US)
- University of Louisville (US)
- Corresponding author
- Patel, Hiren
- Venue
- International Urogynecology Journal
- Published
- 2012-03-20
- Volume
- 23
- Issue
- 6
- Pages
- 669-679
- ISSN
- 0937-3462 (ISSN-L)
- 1433-3023
- OpenAlex
- W2134364902
- Cited by
- 93
- References
- 2
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 13 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Urogynecology Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Surgery › Hernia repair and management
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- polypropylene mesh, pelvic floor reconstruction, host tissue response, mesh implantation, inflammation, mesh integration, tissue ingrowth, mesh pore size, mesh weight, mesh coating, bacterial colonization, biofilm
- MeSH terms
- Animals, Biocompatible Materials, Female, Humans, Materials Testing, Polypropylenes, Urologic Surgical Procedures, Surgical Mesh, Hernia, Abdominal, Pelvic Organ Prolapse, Herniorrhaphy
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