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Cited by 9Sexual function and dysfunction studiesPelvic floor disorders treatmentsUrinary Bladder and Prostate Research

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Expressions of vaginal endothelial nitric oxide synthase and phosphodiesterase 5 in female sexual dysfunction: a pilot study

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Cho, Kang Jun, Lee, Kyu-Sung, Choo, Myung-Soo, Seo, Ju Tae, Kim, Jang Hwan, Choi, Jong Bo, Oh, Seung-June, Kim, Joon Chul·2017·International Urogynecology Journal
DOI 10.1007/s00192-016-3159-5
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Abstract

Introduction and hypothesis The objective was to investigate the expression of endothelial nitric oxide synthase (eNOS) and phosphodiesterase (PDE) 5 in vaginal tissue of premenopausal women experiencing stress urinary incontinence (SUI) with and without sexual dysfunction.Methods Women presenting for treatment of SUI were screened using the Female Sexual Function Index (FSFI) and 10 were selected who met the criteria for female sexual dysfunction (FSD) and 10 asymptomatic controls. Vaginal tissue specimens were obtained from those premenopausal women aged ≥40 years who had had sexual activity ≥2 times every month for the last 6 months and who were scheduled to undergo surgery for SUI. FSD criteria was FSFI scores <18 and arousal domain scores <3. The control group had FSFI scores ≥26 and individual domain scores ≥4. The expressions of eNOS and PDE 5 were compared in the two groups using immunofluorescence staining and western blotting.Results The mean total FSFI scores were 30.4 ± 2.6 and 15.3 ± 2.3 in the control and FSD groups respectively. In immunofluorescence staining, eNOS and PDE5 were localized in the vaginal epithelium. In western blotting, the expressions of eNOS and PDE5 were significantly lower in the FSD group than in the control group (p = 0.003 and p = 0.038 respectively).Conclusions eNOS and PDE5 in the vagina may play important roles in the pathophysiology of FSD.

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Metadata

Authors
Cho, K. J., Lee, K.-S., Choo, M.-S., Seo, J. T., Kim, J. H., Choi, J. B., Oh, S.-J., & Kim, J. C.
Affiliations
  • The Catholic University of Korea Bucheon St. Mary's Hospital (KR)
  • Samsung Medical Center (KR)
  • Asan Medical Center (KR)
  • Cheil General Hospital and Women's Healthcare Center (KR)
  • Yonsei University (KR)
  • Ajou University Hospital (KR)
  • Seoul National University (KR)
Corresponding author
  • Kim, Jang Hwan
  • Kim, Joon Chul
ORCID
Venue
International Urogynecology Journal
Publisher
Springer Science and Business Media LLC
Published
2016-09-29
Volume
28
Issue
3
Pages
431-436
ISSN
  • 0937-3462 (ISSN-L)
  • 1433-3023
DOI
10.1007/s00192-016-3159-5
OpenAlex
W2525179638
Cited by
9
References
26
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1
FWCI
0.59
Type
journal article
Language
en
Open access
Licence
Locations
  • International Urogynecology Journal (publishedVersion)
  • PubMed (publishedVersion)
  • YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
  • AJOU Open Repository (Ajou University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
female sexual dysfunction, endothelial nitric oxide synthase, phosphodiesterase 5, vaginal tissue, stress urinary incontinence, premenopausal women, vaginal epithelium, nitric oxide signaling, Female Sexual Function Index
MeSH terms
Epithelium, Female, Fluorescent Antibody Technique, Humans, Middle Aged, Sexual Dysfunction, Physiological, Urinary Incontinence, Stress, Vagina, Blotting, Western, Biomarkers, Case-Control Studies, Premenopause, Nitric Oxide Synthase, Cyclic Nucleotide Phosphodiesterases, Type 5

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The paper
Cho, K. J., Lee, K.-S., Choo, M.-S., Seo, J. T., Kim, J. H., Choi, J. B., Oh, S.-J., & Kim, J. C. (2017). Expressions of vaginal endothelial nitric oxide synthase and phosphodiesterase 5 in female sexual dysfunction: a pilot study. International Urogynecology Journal. https://doi.org/10.1007/s00192-016-3159-5