Acetaldehyde adducts in the brain of alcoholics
Abstract
Acetaldehyde binds to some proteins and becomes a Schiff base. It is assumed that after the consumption of ethanol the acetaldehyde binds to the proteins to form adducts, and such acetaldehyde adducts are associated with organ diseases. We investigated the detection of acetaldehyde adducts in the brain region of a human alcoholics. Brain samples collected from an alcoholic autopsied case were used. Determination of acetaldehyde adducts was performed using a fluorescence immmunohistochemical staining method with antibodies against acetaldehyde adducts. We demonstrated acetaldehyde adducts in the frontal cortex and the midbrain of an alcoholics. Our studies showed that an acetaldehyde adduct was produced in the brain of alcoholics.
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Ethanol intake or exposure can induce and accelerate AGE production in the brain; aggregation of cross-linked AGEs further upregulates RAGE expression and activation, contributing to diverse outcomes with neurobehavioral impairment, as observed in people with AUD.
“In addition to cerebral AA-protein adducts, ethanol intake or exposure can induce and accelerate AGE production in the brain.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [190]
AA-protein adducts are widely present in the brains of alcohol-exposed rodents or people with AUD; after alcohol consumption they are rapidly produced in the cerebral cortex primarily with mitochondrial proteins and localized in white matter, deep layers of the frontal cortex, and molecular layer of the cerebellum; they also form AA-tubulin adducts causing microtubule malformation and cytoskeletal
“AA-protein adducts are widely present in the brains of alcohol-exposed rodents or people with alcohol use disorder (AUD)189–192.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [190]
Aggregation of AA-protein adducts can enhance neuronal damage and degeneration in different brain regions, suggesting a critical role for AA-protein adducts in promoting brain damage and pathophysiology associated with chronic alcohol consumption.
“Additionally, the aggregation of these AA-protein adducts can enhance neuronal damage and degeneration in different brain regions190,196.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [190]
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References 24 · Cited by 47
- Authors
- Nakamura, K., Iwahashi, K., Furukawa, A., Ameno, K., Kinoshita, H., Ijiri, I., Sekine, Y., Suzuki, K., Iwata, Y., Minabe, Y., & Mori, N.
- Affiliations
- Hamamatsu University (JP)
- Azabu University (JP)
- Corresponding author
- Nakamura, Kazuhiko
- Venue
- Archives of Toxicology
- Published
- 2003-10-01
- Volume
- 77
- Issue
- 10
- Pages
- 591-593
- ISSN
- 0340-5761 (ISSN-L)
- 1432-0738
- OpenAlex
- W2159314321
- Cited by
- 47
- References
- 24
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 1 · 2012: 5
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- acetaldehyde adducts, alcoholism, brain, protein adducts, Schiff base, alcohol metabolism, frontal cortex, midbrain, fluorescence immunohistochemistry, neuropathology
- MeSH terms
- Acetaldehyde, Ethanol, Alcoholism, Brain, Brain Chemistry, Humans, Immunohistochemistry, Liver, Male, Middle Aged, Proteins, Fatal Outcome
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