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Cited by 57Neutrophil, Myeloperoxidase and Oxidative MechanismsOccupational and environmental lung diseasesImmunotoxicology and immune responses

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Carbon black particles increase reactive oxygen species formation in rat alveolar macrophages in vitro

Aam, Berit Bjugan, Fonnum, F.·2007·Archives of Toxicology
DOI 10.1007/s00204-006-0164-3
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Abstract

Alveolar macrophages (AM) have an important role in clearing particles from the lungs. In response to different stimuli they can release reactive oxygen species (ROS) and inflammatory mediators and promote pulmonary inflammation. We exposed rat AM to carbon black (CB) particles (0.63-20 microg/ml) and measured the eneration of ROS by using the fluorescent probe 2',7'-dichlorofluorescein diacetate. Fluorescence was elevated in a concentration dependent manner in the AM exposed to CB. Follow-up experiments using a series of enzyme inhibitors indicate that the ERK MAP kinase pathway and the p38 MAP kinase pathway may be involved in the formation of ROS.

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Metadata

Authors
Aam, B. B., & Fonnum, F.
Affiliations
  • Norwegian Defence Research Establishment (NO)
  • University of Oslo (NO)
Corresponding author
Aam, Berit Bjugan
Venue
Archives of Toxicology
Publisher
Springer Science and Business Media LLC
Published
2006-11-21
Volume
81
Issue
6
Pages
441-446
ISSN
  • 0340-5761 (ISSN-L)
  • 1432-0738
DOI
10.1007/s00204-006-0164-3
OpenAlex
W1976772807
Cited by
57
References
1
Citations by year
2024: 3 · 2022: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 5
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Archives of Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
carbon black particles, alveolar macrophages, reactive oxygen species, oxidative stress, lung inflammation, ERK MAP kinase pathway, particulate matter toxicity
MeSH terms
Animals, Butadienes, Dose-Response Relationship, Drug, Enzyme Inhibitors, Imidazoles, Male, Nitriles, Onium Compounds, Pyridines, Rats, Inbred WKY, Tacrolimus, Macrophages, Alveolar, Reactive Oxygen Species, NADPH Oxidases, MAP Kinase Signaling System, p38 Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 7, MAP Kinase Kinase 5, Rats, Particulate Matter, Soot, In Vitro Techniques

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CoChat. (2026). Citation check: Carbon black particles increase reactive oxygen species formation in rat alveolar macrophages in vitro. https://app.cochat.ai/papers/10.1007/s00204-006-0164-3
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Aam, B. B., & Fonnum, F. (2007). Carbon black particles increase reactive oxygen species formation in rat alveolar macrophages in vitro. Archives of Toxicology. https://doi.org/10.1007/s00204-006-0164-3