Cited by 347Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Do animal models of anxiety predict anxiolytic-like effects of antidepressants?

Borsini, Franco, Podhorna, Jana, Marazziti, Donatella·2002·Psychopharmacology

DOI 10.1007/s00213-002-1155-6

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Abstract

Chronically administered antidepressant drugs, particularly selective serotonin (5-HT) reuptake inhibitors (SSRIs), are clinically effective in the treatment of all anxiety disorders, while the clinical effectiveness of "traditional" anxiolytics, such as benzodiazepines (BDZs), is limited to generalised anxiety disorder or acute panic attacks. This implies that animal models of anxiety should be sensitive to SSRIs and other antidepressants in order to have predictive validity. We reviewed the literature on the effects of antidepressants in the so-called animal models of anxiety and found that only the isolation-induced calls in guinea-pig pups may reveal anxiolytic-like action of all antidepressant classes after acute administration. Some other models, such as marble-burying or conditioned-freezing behaviours, and isolation- or shock-induced ultrasonic vocalisation models, may detect anxiolytic-like activity of acutely administered antidepressants, although the sensitivity of these models is usually limited to SSRIs and other drugs affecting 5-HT uptake. The predictive validity of models of "anxiety", such as the plus-maze and light-dark transition tests or stress-induced hyperthermia, appears to be limited to BDZ-related drugs. Far less work has been done on chronic administration of antidepressants in animal anxiety models. Unless and until such studies have been undertaken, the true predictive value of the anxiety models will remain unknown.

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Authors: Borsini, F., Podhorna, J., & Marazziti, D.
Affiliations: Boehringer Ingelheim (Germany) (DE)
University of Pisa (IT)
ORCID: Marazziti, Donatella
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2002-09-01
Volume: 163
Issue: 2
Pages: 121-141
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-002-1155-6
OpenAlex: W2069192879
Cited by: 347
References: 1
Citations by year: 2026: 1 · 2025: 2 · 2024: 8 · 2023: 12 · 2022: 8 · 2021: 10 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 12 · 2016: 14 · 2015: 17 · 2014: 21 · 2013: 9 · 2012: 12
FWCI: 6.04
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: animal models of anxiety, antidepressants, anxiolytic-like effects, selective serotonin reuptake inhibitors, benzodiazepines, predictive validity, marble burying test, conditioned freezing, ultrasonic vocalizations, plus-maze test, light-dark transition test, stress-induced hyperthermia, anxiety disorders
MeSH terms: Animals, Antidepressive Agents, Tricyclic, Anxiety, Disease Models, Animal, Forecasting, Humans, Anti-Anxiety Agents

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Do animal models of anxiety predict anxiolytic-like effects of antidepressants?

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