Hippocampal Function in Cognition
Abstract
Rationale and objectives Any consideration of cognitive disruption in schizophrenia quite naturally leads to questions concerning the cellular and molecular mechanisms underlying normal cognition. This review will describe emerging models for the cellular basis of cognitive processing in the hippocampus.Methods and results This review will describe results from several laboratories that have used in vivo recording in behaving rodents to probe the role of the hippocampus in cognition. These exciting studies have indicated a broader role of the hippocampus in general information processing than was previously appreciated. These recent results suggest that the hippocampus is involved in minute-to-minute cognitive processing including spatial information processing, temporal sequencing, and formulating the relationships between objects in the environment.Conclusions The hippocampus appears to play a major role in bringing together environmental signals and producing a cohesive and unified percept in the spatial and temporal domains. This new view of the role of the hippocampus in cognition fits strikingly well with models for schizophrenia hypothesizing hippocampal dysfunction as one cause of cognitive decline in schizophrenic patients.
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Collectively, these studies provide some evidence that the hippocampus is vulnerable to long-chain PFAS exposure and warrants further assessment.
“Collectively, these studies provide some evidence that the hippocampus, a brain region critical for spatial learning and memory as well as anxiety-like behavior, is vulnerable to long-chain PFAS exposure and warrants further assessment (Bannerman et al., 2004; Sweatt, 2004).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Sweatt, 2004
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References 53 · Cited by 217
- Authors
- Sweatt, J. D.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Sweatt, J.David
- ORCID
- Sweatt, J.David
- Venue
- Psychopharmacology
- Published
- 2004-03-02
- Volume
- 174
- Issue
- 1
- Pages
- 99-110
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2122817044
- Cited by
- 217
- References
- 53
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 13 · 2023: 5 · 2022: 9 · 2021: 13 · 2020: 13 · 2019: 13 · 2018: 6 · 2017: 5 · 2016: 15 · 2015: 9 · 2014: 14 · 2013: 14 · 2012: 1
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- hippocampus, cognition, schizophrenia, hippocampal dysfunction, spatial data processing, temporal sequencing, object relations
- MeSH terms
- Animals, Blinking, Cognition, Hippocampus, Humans, Memory, Mental Processes, Nerve Net, Neurons, Space Perception, Maze Learning
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