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Effects of isradipine on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition
Abstract
Rationale While the effects of d-amphetamine in increasing performance have been established, there is a paucity of information on the effects of methamphetamine on cognition in drug-naive subjects, and no published information on the effects of intravenous methamphetamine administration in dependent individuals. The dihydropyridine-class calcium channel antagonist, isradipine, has been posited as a putative treatment to prevent methamphetamine-associated hypertensive crisis and its sequelae. Yet, isradipine's effects on cognitive performance in methamphetamine-dependent individuals are not known.Objective Since individuals whose dependence on methamphetamine is attributable to the need to enhance performance may be loath to take a cognition-impairing medication, even for the treatment of life-threatening hypertensive crisis, it would be important to determine isradipine's effects on performance.Methods We therefore examined in a blinded, placebo-controlled, crossover design the cognitive effects of low and high doses of intravenous methamphetamine (15 mg and 30 mg, respectively) in both the presence and absence of isradipine.Results Intravenous d-methamphetamine produced dose-dependent increases in attention, concentration, and psychomotor performance. Isradipine, both with and without methamphetamine, had a modest effect to decrease attention.Conclusion Our results do not support the further testing of isradipine as a medication for improving the cognitive impairments that have been associated with chronic methamphetamine use.
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“Methamphetamine (MA) is a psychostimulant that when used regularly is associated with harms such as injecting and sexual risk-taking behaviour, symptoms of mental ill health (eg, psychosis, aggression, depression and/or anxiety), psychomotor, social and cognitive impairment, criminal activity and sometimes death caused by overdose.1–7”
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Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis
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ResultAcute Physiological and Behavioral Effects of Intranasal Methamphetamine in Humans
Hart, C. L., Gunderson, E. W., Perez, A. Y., Kirkpatrick, M. G., Thurmond, A., Comer, S. D., & Foltin, R. W. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301578 · Cited by 126
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BackgroundResult
Metadata
- Authors
- Johnson, B. A., Roache, J. D., Ait-Daoud, N., Wallace, C., Wells, L. T., & Wang, Y.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Johnson, Bankole A.
- Venue
- Psychopharmacology
- Published
- 2004-09-25
- Volume
- 178
- Issue
- 2-3
- Pages
- 296-302
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2079204173
- Cited by
- 33
- References
- 49
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2014: 3 · 2013: 1
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da012969-02)
- National Institute on Drug Abuse (R01DA12969-04)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- isradipine, methamphetamine, cognitive performance, attention, psychomotor performance, dihydropyridine calcium channel antagonists, drug addiction, hypertensive crisis, dose-dependent effects
- MeSH terms
- Adult, Antihypertensive Agents, Attention, Calcium Channel Blockers, Dose-Response Relationship, Drug, Double-Blind Method, Drug Interactions, Drug Therapy, Combination, Female, Humans, Male, Methamphetamine, Psychomotor Performance, Reaction Time, Substance Abuse, Intravenous, Treatment Outcome, Isradipine, Cross-Over Studies, Area Under Curve, Amphetamine-Related Disorders
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