Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia
Abstract
Rationale Several investigators implicated role of free radical-mediated pathology in schizophrenia. No study has ever examined the effect of vitamin C with atypical antipsychotics in the treatment of schizophrenia.Objective The aim of this study was to examine the effect of oral vitamin C with atypical antipsychotics on serum malondialdehyde (MDA), plasma ascorbic acid levels, and brief psychiatric rating scale (BPRS) score in schizophrenic patients.Method Forty schizophrenic patients participated in a prospective, double-blind, placebo-controlled, noncrossover, 8-week study. The patients with schizophrenia were divided randomly into placebo and vitamin C group of 20 each. Serum MDA and plasma ascorbic acid were estimated by methods of Nischal and Aye, respectively.Result Increased serum MDA and decreased plasma ascorbic acid levels were found in schizophrenic patients. These levels were reversed significantly after treatment with vitamin C along with atypical antipsychotics compared to placebo with atypical antipsychotics. BPRS change scores at 8 weeks improved statistically significant with vitamin C as compared to placebo.Conclusion Oral supplementation of vitamin C with atypical antipsychotic reverses ascorbic acid levels, reduces oxidative stress, and improves BPRS score, hence both the drugs in combination can be used in the treatment of schizophrenia.
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Vitamin C supplementation in schizophrenic patients normalizes plasma levels of ascorbic acid and malondialdehyde abnormalities.
“Vitamin C supplementation in schizophrenic patients has been reported to normalize not only plasma levels of ascorbic acid but also malondialdehyde abnormalities (Dakhale et al. 2005).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Dakhale et al. 2005
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References 25 · Cited by 131
- Authors
- Dakhale, G. N., Khanzode, S. D., Khanzode, S. S., & Saoji, A.
- Affiliations
- Government Medical College (IN)
- Corresponding author
- Khanzode, S. D.
- ORCID
- Dakhale, G. N.
- Venue
- Psychopharmacology
- Published
- 2005-08-13
- Volume
- 182
- Issue
- 4
- Pages
- 494-498
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2091456872
- Cited by
- 131
- References
- 25
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 12 · 2021: 6 · 2020: 11 · 2019: 2 · 2018: 8 · 2017: 6 · 2016: 2 · 2015: 6 · 2014: 7 · 2013: 13 · 2012: 7
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Keywords
- vitamin C supplementation, atypical antipsychotics, schizophrenia, oxidative stress, malondialdehyde, vitamin C, free radicals, Brief Psychiatric Rating Scale, combination therapy
- MeSH terms
- Adult, Analysis of Variance, Ascorbic Acid, Female, Humans, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Schizophrenia, Time Factors, Antipsychotic Agents, Treatment Outcome, Oxidative Stress
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