Potential programming of dopaminergic circuits by early life stress
Open accessAbstract
Stress and high levels of glucocorticoids during pre- and early postnatal life seem to alter developmental programs that assure dopaminergic transmission in the mesolimbic, mesocortical, and nigrostriatal systems. The induced changes are likely to be determined by the ontogenetic state of development of these brain regions at the time of stress exposure and their stability is associated with increased lifetime susceptibility to psychiatric disorders, including drug addiction. This article is intended to serve as a starting point for future studies aimed at the attenuation or reversal of the effects of adverse early life events on dopamine-regulated behaviors.
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There may be critical periods, such as during childhood, in which neural systems are particularly vulnerable to sensitization by stress.
“In particular, there may be critical periods, such as during childhood, in which neural systems are particularly vulnerable to sensitization by stress (Rodrigues, Leão, Carvalho, Almeida, & Sousa, 2011).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Rodrigues, Leão, Carvalho, Almeida, & Sousa, 2011
Stressful experiences during early development may sensitize mesolimbic dopamine signaling in neural regions, inducing permanent changes in the neural programming of dopaminergic activity.
“There is substantial evidence to support that stressful experiences during early development may sensitize mesolimbic dopamine signaling in neural regions, inducing permanent changes in the neural programming of dopaminergic activity (Rodrigues et al., 2011).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Rodrigues et al., 2011
Individuals experiencing stressful events during early life and adolescence are particularly prone for developing cross-sensitization to drugs of abuse.
“In particular, evidence suggests that final maturation of behavior, dopamine systems, and HPA axis occurs during adolescence, suggesting that individuals experiencing stressful events during early life and adolescence are particularly prone for developing cross-sensitization to drugs of abuse (Burke & Miczek, 2014; Rodrigues et al., 2011).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Rodrigues et al., 2011
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References 206 · Cited by 97
- Authors
- Rodrigues, A.-J., Leão, P., Carvalho, M., Almeida, O. F. X., & Sousa, N.
- Affiliations
- University of Minho (PT)
- Max Planck Society (DE)
- Corresponding author
- Sousa, Nuno
- Venue
- Psychopharmacology
- Published
- 2010-11-19
- Volume
- 214
- Issue
- 1
- Pages
- 107-120
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2140853453
- Cited by
- 97
- References
- 206
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 13 · 2020: 10 · 2019: 1 · 2018: 6 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 7 · 2013: 9 · 2012: 1
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- early life stress, dopaminergic circuits, glucocorticoids, mesolimbic system, nigrostriatal pathway, dopamine signaling, developmental programming, mental illness, drug addiction, adverse childhood experiences
- MeSH terms
- Animals, Mental Disorders, Brain, Disease Susceptibility, Dopamine, Glucocorticoids, Humans, Life Change Events, Stress, Psychological, Substance-Related Disorders
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