Interaction between cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC): influence of administration interval and dose ratio between the cannabinoids
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The pharmacokinetic interaction that results in the blockade of P-450 cytochromes by CBD and inhibits the metabolism of Δ9-THC can be overcome by a pharmacodynamic interaction, when the CBD/Δ9-THC ratio is high and/or administration of the two cannabinoids occurs simultaneously or very close in time.
“Nowadays, we have evidence that the pharmacokinetic interaction that results in the blockade of P-450 cytochromes by CBD and inhibits the metabolism of Δ9-THC can be overcome by a pharmacodynamic interaction, when the CBD/Δ9-THC ratio is high and/or administration of the two cannabinoids occurs simultaneously or very close in time (14).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [14]
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References 16 · Cited by 84
- Authors
- Zuardi, A. W., Hallak, J. E. C., & Crippa, J. A. S.
- Affiliations
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
- Venue
- Psychopharmacology
- Published
- 2011-09-21
- Volume
- 219
- Issue
- 1
- Pages
- 247-249
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2065079281
- Cited by
- 84
- References
- 16
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 4
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Keywords
- cannabidiol, delta-9-tetrahydrocannabinol, dose ratio
- MeSH terms
- Animals, Behavior, Animal, Cannabidiol, Male, Dronabinol
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