Effects of nicotine withdrawal on cognition in a clinical trial setting
Abstract
Rationale Smoking withdrawal has been widely established to produce a range of impairments to the quality of several major domains of cognitive function including attention, working memory and episodic memory.Objectives This study was conducted to determine the degree to which smoking withdrawal will produce impairments in cognitive function in phase I clinical trials.Methods Healthy male volunteers who were housed in a clinical trial facility for 16 days underwent periods of ad libitum smoking and smoking withdrawal.Results Smoking withdrawal disrupted aspects of attention and episodic verbal recall and recognition.Conclusions This study confirms previous work showing cognitive declines in smoking withdrawal and illustrates that such effects occur in ongoing safety and tolerability studies of new medicines and thus require careful consideration for the assessment of cognitive function in such trials as well as the accurate attribution of adverse events to the safety profiles of the medicines.
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Cognitive deficits manifest during nicotine withdrawal, including difficulty concentrating, increased reaction times in sustained attention tasks, and impaired episodic and working memory.
“In addition, there are cognitive deficits that manifest during nicotine withdrawal, including difficulty concentrating, increased reaction times in tasks requiring sustained attention, and impaired episodic and working memory (Myers et al. 2008; Wesnes et al. 2013).”
From Nicotine Withdrawal (2015) · cites this paper as Wesnes et al. 2013
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References 20 · Cited by 31
- Authors
- Wesnes, K. A., Edgar, C. J., Kezic, I., Salih, H. M., & de Boer, P.
- Affiliations
- Swinburne University of Technology (AU)
- Johnson & Johnson (United States) (US)
- SGS (Belgium) (BE)
- Corresponding author
- Wesnes, Keith A.
- Venue
- Psychopharmacology
- Published
- 2013-04-17
- Volume
- 229
- Issue
- 1
- Pages
- 133-140
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2063899748
- Cited by
- 31
- References
- 20
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 3
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- nicotine withdrawal, cognitive impairment, attention, episodic memory, word recall, recognition memory, clinical trial safety, drug safety assessment
- MeSH terms
- Adult, Cognition, Humans, Male, Middle Aged, Nicotine, Reaction Time, Smoking, Substance Withdrawal Syndrome, Smoking Cessation, Young Adult
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