Allopregnanolone modulation of HPA axis function in the adult rat
Abstract
Rationale GABAergic neuronal circuits regulate neuroendocrine stress response, and the most potent positive endogenous modulator of GABAA receptor function is allopregnanolone. This neurosteroid acts in a nongenomic manner to selectively increase the inhibitory signal meditated by GABAA receptors; in addition, it also induces long-lasting changes in the expression of specific GABAA receptor subunits in various brain regions, with consequent changes in receptor function.Objective The objective of this review is to summarize our findings on emotional state and stress responsiveness in three animal models in which basal brain concentrations of allopregnanolone differ. It is postulated that individual differences in allopregnanolone levels can influence general resilience.Results The results showed that there is an apparent correlation between endogenous levels of brain allopregnanolone and basal and stress-stimulated HPA axis activity.Conclusion The relationship between endogenous brain levels of allopregnanolone and HPA axis activity and function sustains the therapeutic potential of this neurosteroid for the treatment of stress-associated disorders.
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Studies in rodents show an inhibitory effect of allopregnanolone on the function of the HPA axis.
“Studies in rodents show an inhibitory effect of allopregnanolone on the function of the HPA axis (77–79).”
From Higher Circulating Cortisol in the Follicular vs. Luteal Phase of the Menstrual Cycle: A Meta-Analysis (2020) · cites this paper as [79]
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References 67 · Cited by 40
- Authors
- Biggio, G., Pisu, M. G., Biggio, F., & Serra, M.
- Affiliations
- University of Cagliari (IT)
- Corresponding author
- Biggio, Giovanni
- Venue
- Psychopharmacology
- Published
- 2014-03-22
- Volume
- 231
- Issue
- 17
- Pages
- 3437-3444
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1964415730
- Cited by
- 40
- References
- 67
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 6 · 2014: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- allopregnanolone, hypothalamic-pituitary-adrenal axis, neurosteroids, GABAA receptor, stress response, emotional state, stress resilience, neuroendocrine stress response, GABAA receptor subunits
- MeSH terms
- Animals, Hypothalamo-Hypophyseal System, Maternal Deprivation, Pituitary-Adrenal System, Pregnanolone, Social Isolation, Rats, Resilience, Psychological
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