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Cited by 54Cannabis and Cannabinoid ResearchMemory and Neural MechanismsPosttraumatic Stress Disorder Research

The DOI matches its Crossref record; 267 of the 268 references it cites were found in a registry or an index.

Tempering aversive/traumatic memories with cannabinoids: a review of evidence from animal and human studies

Lisboa, Sabrina F., Vila-Verde, C., Rosa, J., Uliana, D. L., Stern, C. A. J., Bertoglio, L. J., Resstel, L. B., Guimaraes, F. S.·2019·Psychopharmacology
DOI 10.1007/s00213-018-5127-x
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Abstract

Rationale Aversive learning and memory are essential to cope with dangerous and stressful stimuli present in an ever-changing environment. When this process is dysfunctional, however, it is associated with posttraumatic stress disorder (PTSD). The endocannabinoid (eCB) system has been implicated in synaptic plasticity associated with physiological and pathological aversive learning and memory.Objective and methods The objective of this study was to review and discuss evidence on how and where in the brain genetic or pharmacological interventions targeting the eCB system would attenuate aversive/traumatic memories through extinction facilitation in laboratory animals and humans. The effect size of the experimental intervention under investigation was also calculated.Results Currently available data indicate that direct or indirect activation of cannabinoid type-1 (CB1) receptor facilitates the extinction of aversive/traumatic memories. Activating CB1 receptors around the formation of aversive/traumatic memories or their reminders can potentiate their subsequent extinction. In most cases, the effect size has been large (Cohen's d ≥ 1.0). The brain areas responsible for the abovementioned effects include the medial prefrontal cortex, amygdala, and/or hippocampus. The potential role of cannabinoid type-2 (CB2) receptors in extinction learning is now under investigation.Conclusion Drugs augmenting the brain eCB activity can temper the impact of aversive/traumatic experiences by diverse mechanisms depending on the moment of their administration. Considering the pivotal role the extinction process plays in PTSD, the therapeutic potential of these drugs is evident. The sparse number of clinical trials testing these compounds in stress-related disorders is a gap in the literature that needs to be addressed.

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Crossref · 10.1007/s00213-018-5127-x

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267 of 267 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. Egertová M, Giang DK, Cravatt BF, Elphick MR (1998) A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proc Biol Sci 265:2081–2085 · DOI

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Metadata

Authors
Lisboa, S. F., Vila-Verde, C., Rosa, J., Uliana, D. L., Stern, C. A. J., Bertoglio, L. J., Resstel, L. B., & Guimaraes, F. S.
Affiliations
  • Universidade de São Paulo (BR)
  • Universidade Federal do Paraná (BR)
  • Universidade Federal de Santa Catarina (BR)
Corresponding author
Lisboa, Sabrina F.
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2019-01
Volume
236
Issue
1
Pages
201-226
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-018-5127-x
OpenAlex
W2907417472
Cited by
54
References
268
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 16 · 2020: 10 · 2019: 4
FWCI
1.28
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2012/17626-7)
  • Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (465458/2014-9)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords
endocannabinoid system, cannabinoid type 1 receptor, cannabinoid type 2 receptor, post-traumatic stress disorder, aversive memory, traumatic memory, memory extinction, medial prefrontal cortex, amygdala, hippocampus, synaptic plasticity, stress-related disorders, cannabinoid receptor agonists
MeSH terms
Amygdala, Animals, Avoidance Learning, Cannabinoids, Extinction, Psychological, Fear, Hippocampus, Humans, Neuronal Plasticity, Stress Disorders, Post-Traumatic, Prefrontal Cortex

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