The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood
Abstract
The neonatal ibotenic acid lesion of the ventral hippocampus in the rat is an animal model of several aspects of schizophrenia. This lesion produces a number of behavioural abnormalities, such as hyperlocomotion and deficits in prepulse inhibition of startle, that present themselves relatively late in development, i.e. after puberty. Some of these abnormalities, which are thought to model the positive symptoms of schizophrenia, can be normalized by chronic treatment with neuroleptics. In the present study, we examined the effects of the neonatal hippocampal lesion on social behaviour. Social withdrawal and isolation are key components of the negative symptoms of schizophrenia that have not been previously addressed in this model. Rats were lesioned on postnatal day 7 (PD7) and tested for social interaction on PD35 and PD65. They were then treated with clozapine (1.9 and 7.4 micromol/kg or 0.63 and 2.5 mg/kg) for 21 days and retested. The results show that although, as previously reported, spontaneous hyperlocomotion emerged in the lesioned rats only after puberty (PD65), social interaction deficits and behaviors that may reflect anxiety were present at both PD35 and PD65. Clozapine normalized locomotion, but did not ameliorate putative anxiety or social interaction deficits in the neonatally lesioned rats. Our results indicate that the neonatal hippocampal lesion in the rat models some aspects of both positive and negative symptoms of schizophrenia. The effects of clozapine appear inconsistent with its putative benefit for negative symptoms.
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“Behaviorally, adult rats with a NVHL show hyperlocomotion, 39,40 increased response to novelty, 41 abnormal social behaviors, 41 exaggerated responses to stress, stimulants and NMDA antagonists, 39,42 and increased liability for addictive behaviors.43,44”
From Adolescent Onset of Cortical Disinhibition in Schizophrenia: Insights From Animal Models (2011) · cites this paper as [41]
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Clozapine for the Treatment-Resistant Schizophrenic: A Double-blind Comparison With Chlorpromazine
Kane, J. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800330013001 · Cited by 4,156
File, S. E. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90012-6 · Cited by 820
Lipska, B. K., Jaskiw, G. E., & Weinberger, D. R. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.44 · Cited by 697
Self-citationEffects of clozapine on positive and negative symptoms in outpatients with schizophrenia
Breier, A. F., Buchanan, R. W., Kirkpatrick, B. W., Davis, O. R., Irish, D., Summerfelt, A. T., & Carpenter, W. T. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.1.20 · Cited by 388
Lipska, B. K., Weinberger, D. R., Swerdlow, N. R., Geyer, M. A., BRAFF, D. L., & Jaskiw, G. E. (1995) · Psychopharmacology · doi:10.1007/bf02246439 · Cited by 356
Self-citationComparison of Amphetamine Psychosis and Schizophrenia
Bell, D. S. (1965) · The British Journal of Psychiatry · doi:10.1192/bjp.111.477.701 · Cited by 328
The Effect of Clozapine on Cognition and Psychiatric Symptoms in Patients with Schizophrenia
Goldberg, T. E., Greenberg, R. D., Griffin, S. J., Gold, J. M., Kleinman, J. E., Pickar, D., Schulz, S. C., & Weinberger, D. R. (1993) · The British Journal of Psychiatry · doi:10.1192/bjp.162.1.43 · Cited by 289
Self-citationBartosik, V. (2008) · Wiley eBooks · doi:10.1002/9780470373699.speced0124 · Cited by 281
Phencyclidine-induced stereotyped behaviour and social isolation in rats
Sams‐Dodd, F. (1996) · Behavioural Pharmacology · doi:10.1097/00008877-199601000-00001 · Cited by 247
Self-citationA STUDY OF A 1-ARYL CYCLO HEXYL AMINE FOR ANESTHESIA*
GREIFENSTEIN, F. E., DEVAULT, M., Yoshitake, J., & GAJEWSKI, J. E. (1958) · Anesthesia & Analgesia · doi:10.1213/00000539-195809000-00007 · Cited by 202
The excitatory amino acid antagonist d-CPP-ene (SDZ EAA-494) in patients with epilepsy
Sveinbjörnsdóttir, S., Sander, J. W. A. S., Upton, D., Thompson, P. J., Patsalos, P. N., Hirt, D., Emre, M., Lowe, D., & Duncan, J. S. (1993) · Epilepsy Research · doi:10.1016/0920-1211(93)90031-2 · Cited by 200
EPIDEMIOLOGY OF SCHIZOPHRENIA1
EATON, W. W. (1985) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036278 · Cited by 194
Phencyclidine and ketamine intoxication: a study of four populations of recreational users.
Siegel, R. K. (1978) · PubMed · Cited by 134
Lipska, B. K., & Weinberger, D. R. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.22 · Cited by 131
Self-citationCHILDHOOD PRECURSORS OF ADULT SCHIZOPHRENIA
Nuechterlein, K. H. (1986) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1986.tb02327.x · Cited by 48
McLaren, S., Cookson, J., & Silverstone, T. (1992) · International Clinical Psychopharmacology · doi:10.1097/00004850-199207020-00001 · Cited by 35
Neurobehavioral functioning and social behavior of children at risk for schizophrenia.
Auerbach, J. G., Hans, S. L., & Marcus, J. H. (1993) · PubMed · Cited by 23
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Automated apparatus for quantitation of social approach behaviors in mice
Nadler, J. J., Moy, S. S., Dold, G., Trang, D., Simmons, N., Perez, A., Young, N. B., Barbaro, R. P., Piven, J., Magnuson, T. R., et al. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00071.x · Cited by 775
Animal models of schizophrenia
Jones, C., Watson, D., & Fone, K. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01386.x · Cited by 771
A review of 25 years of the social interaction test
File, S. E., & Seth, P. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01273-1 · Cited by 763
Prefrontal neurons and the genetics of schizophrenia
Weinberger, D. R., Egan, M. F., Bertolino, A., Callicott, J. H., Mattay, V. S., Lipska, B. K., Berman, K. F., & Goldberg, T. E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01252-5 · Cited by 751
Self-citationTo Model a Psychiatric Disorder in Animals Schizophrenia As a Reality Test
Lipska, B. K. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00137-8 · Cited by 663
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Metadata
- Authors
- Sams-Dodd, F., Lipska, B. K., & Weinberger, D. R.
- Affiliations
- National Institutes of Health (US)
- Venue
- Psychopharmacology
- Published
- 1997-08-05
- Volume
- 132
- Issue
- 3
- Pages
- 303-310
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2036180008
- Cited by
- 346
- References
- 17
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 10 · 2018: 10 · 2017: 8 · 2016: 14 · 2015: 15 · 2014: 21 · 2013: 14 · 2012: 17
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- ventral hippocampus, ibotenic acid, animal models of schizophrenia, social behavior, social withdrawal, negative symptoms of schizophrenia, positive symptoms, hyperlocomotion, clozapine, antipsychotic drugs, anxiety, social interaction deficits
- MeSH terms
- Animals, Animals, Newborn, Behavior, Animal, Clozapine, Female, Hippocampus, Male, Motor Activity, Social Behavior, Antipsychotic Agents, Rats, Sprague-Dawley, Rats
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