The DOI matches its Crossref record.
Antidepressant effects of nicotine in an animal model of depression
Abstract
Epidemiological studies indicate a high incidence of cigarette smoking among depressed individuals. Moreover, individuals with a history of depression have a much harder time giving up smoking. It has been postulated that smoking may reflect an attempt at self-medication with nicotine by these individuals. Although some animal and human studies suggest that nicotine may act as an antidepressant, further verification of this hypothesis and involvement of nicotinic cholinergic system in depressive symptoms is required. Flinders Sensitive Line (FSL) rats have been proposed as an animal model of depression. These rats, selectively bred for their hyperresponsiveness to cholinergic stimulation, show an exaggerated immobility in the forced swim test compared to their control Flinders Resistant Line (FRL) rats. Acute or chronic (14 days) administration of nicotine (0.4 mg/kg s.c.) significantly improved the performance of the FSL but not the FRL rats in the swim test. The effects of nicotine on swim test were dissociable from its effects on locomotor activity. Moreover, the FSL rats had significantly higher [3H]cytisine binding (selective for the alpha4beta2 nicotinic receptor subtype) but not [125I]alpha-bungarotoxin binding (selective for the alpha7 subtype) in the frontal cortex, striatum, midbrain and colliculi compared to FRL rats. These data strongly implicate the involvement of central nicotinic receptors in the depressive characteristics of the FSL rats, and suggest that nicotinic agonists may have therapeutic benefits in depressive disorders.
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In the citing paper
“Animal studies have also shown that chronic nicotine administration can elicit antidepressant-like effects in rats both in the learned helplessness (Semba et al., 1998) and the forced swim (Djuric et al., 1999; Tizabi et al., 1999) paradigms.”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Tizabi et al., 1999
In the citing paper
“Furthermore, nicotine binds to neuronal nicotinic acetylcholine receptors (nAChRs) and partial agonists and antagonists of nAChRs including nicotine (14), mecamylamine and dihydro-beta-erythroidine (DHβE) (15), cytisine (16) and varenicline (17), have antidepressant-like effects in preclinical studies.”
From Persistent β 2 *-Nicotinic Acetylcholinergic Receptor Dysfunction in Major Depressive Disorder (2012) · cites this paper as [14]
In the citing paper
“many studies have reported that nicotine can improve symptoms of depression under some conditions (Salin-Pascual et al., 1995; Tizabi et al., 1999)”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Tizabi et al., 1999
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Items 201–210 of 210
Faccin, G. L., Amante, E. R., Tramonte, V. L. C. G., et al. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2009.0180
“14,15 The FS test is the model most widely used in pharmacology to evaluate antidepressant activity in vivo .”
Antkiewicz‐Michaluk, L., Michaluk, J., Romańska, I., Popik, P., Krawczyk, M., Nalepa, I., & Vetulani, J. (2006) · PubMed
Development of Antidepressant Drugs Through Targeting α4β2-Nicotinic Acetylcholine Receptors
Zhang, H., Gunosewoyo, H., Fan, Y., Tang, J., & Yu, L.-F. (2016) · Neuromethods · doi:10.1007/978-1-4939-3768-4_11
Psychiatrische Komorbiditäten bei tabakbedingten Störungen
Psychiatrie, A., & Tübingen, U. (2016)
Long-Term Oral Nicotine Treatment and Daily Variations in Brain Monoamines and Motor Activity
Gäddnäs, H. (2002) · Työväentutkimus Vuosikirja
Changes in Affect Following Smoking Cessation in Depressed Smokers
Mathew, A. R. (2013) · Cited by 1
3.タバコ,潜在的うつ状態と心血管疾患(禁煙治療の現状と発展,第9回禁煙推進セミナー)
長谷川, 浩., 和田, 啓., & 裕子, 高. (2010) · Journal of JCS Cardiologists · doi:10.1253/jjcsc.18.2_352
Risdiana, N., Susilowati, R., Sholikhah, E. N., & Partadiredja, G. (2022) · BIO Web of Conferences · doi:10.1051/bioconf/20224901002
“This depends on the species, strain, and sex of experimental animals used [32].”
BackgroundPeter‐Derex, L., Fort, E., Putois, B., Martel, N., Ricordeau, F., Bastuji, H., Arnulf, I., Barateau, L., Bourgin, P., Dauvilliers, Y. A., et al. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.02.037
Metadata
- Authors
- Tizabi, Y., Overstreet, D. H., Rezvani, A. H., Louis, V. A., Clark Jr, E., Janowsky, D. S., & Kling, M. A.
- Affiliations
- Howard University (US)
- University of North Carolina at Chapel Hill (US)
- University of Maryland, Baltimore (US)
- Venue
- Psychopharmacology
- Published
- 1999-02-18
- Volume
- 142
- Issue
- 2
- Pages
- 193-199
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2049363507
- Cited by
- 209
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 14 · 2014: 5 · 2013: 12 · 2012: 10
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- nicotine, antidepressant effects, depression, Flinders Sensitive Line rats, forced swim test, immobility, nicotinic acetylcholine receptors, alpha4beta2 nicotinic receptor, alpha7 nicotinic acetylcholine receptor, self-medication, smoking, locomotor activity, frontal cortex, striatum, midbrain, colliculi
- MeSH terms
- Quinolizidine Alkaloids, Alkaloids, Animals, Antidepressive Agents, Azocines, Binding Sites, Body Temperature, Bungarotoxins, Depression, Disease Models, Animal, Iodine Radioisotopes, Male, Motor Activity, Nicotine, Quinolizines, Receptors, Nicotinic, Tritium, Nicotinic Agonists, Rats
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