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Effects of synthetic Δ 9 -tetrahydrocannabinol on binocular depth inversion of natural and artificial objects in man
Abstract
Binocular depth inversion represents an illusion of visual perception that is sensitive to various behavioural and psychiatric conditions. It is affected by cannabinoids, reflecting associated changes in perception. The present study investigated the differences in binocular depth inversion of different classes of natural and artificial objects and the effect of synthetic delta9-tetrahydrocannabinol (Dronabinol) on these illusionary perceptions. Using this model, the effects of orally administered Dronabinol on binocular depth inversion were investigated in 17 healthy male volunteers. Pictures from natural and artificial objects were presented stereoscopically and the depth perception of the volunteers was scored in an operationalized way. The timecourse of the effects of Dronabinol on binocular depth inversion was analyzed with regard to the stimulus classes (natural and synthetic objects). Significant differences in binocular depth inversion of the different groups of stimuli were revealed. Objects with a higher degree of everyday familiarity were generally seen as more illusionary than those with a lower degree of everyday familiarity. A strong impairment of binocular depth inversion due to Dronabinol was found in most classes of objects. Analysis of different stimulus classes provides further information on the underlying perceptual processing of binocular depth inversion. An impairment of top-down processing of visual sensory data by Dronabinol is suggested. The anandamidergic system seems to be involved in areas of visual information processing.
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“other studies have suggested that the induction of “pro-psychotic” states in non-clinical populations, via, for example, acute cannabinoids (Emrich et al., 1997; Leweke et al., 1999; Koethe et al., 2006), chronic intoxication (Semple et al., 2003) or sleep deprivation (Sternemann et al., 1997), enable to experimentally reduce sensitivity to VIs.”
From What visual illusions teach us about schizophrenia (2014) · cites this paper as Leweke et al., 1999
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Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
Leweke, F. M., Piomelli, D., Pahlisch, F., Muhl, D., Gerth, C. W., Hoyer, C., Klosterkötter, J., Hellmich, M., & Koethe, D. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.15 · Cited by 1,059
Self-citationD'Souza, D. C., Perry, E., MacDougall, L., Ammerman, Y., Cooper, T., Wu, Y.-T., Braley, G., Gueorguieva, R., & Krystal, J. H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300496 · Cited by 1,024
“…(Andreasson et al, 1987, 1988, 1989; Arseneault et al, 2002; McGuire et al, 1995; Zammit et al, 2002), genetic (Ujike et al, 2002), neurochemical (Leweke et al, 1999a), and postmortem (Dean et al, 2001) approaches, suggesting that the consumption of cannabinoids (exogenous) and/or brain…”
BackgroundResultGiuffrida, A., Leweke, F. M., Gerth, C. W., Schreiber, D., Koethe, D., Faulhaber, J., Klosterkötter, J., & Piomelli, D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300558 · Cited by 481
“…signaling may be associated with schizophrenia is further supported by studies showing that endocannabinoid levels in cerebrospinal fluid (CSF) (Leweke et al, 1999b) and plasma (Yao et al, 2002; De Marchi et al, 2003) as well as CB1 receptor expression (Dean et al, 2001) are abnormal in…”
BackgroundResultSelf-citationSchneider, M., & Koch, M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300225 · Cited by 425
“…and for a possible dysregulation in the endogenous cannabinoid system being associated with the pathogenesis of schizophrenia (Emrich et al, 1997; Leweke et al, 1999a; Dean et al, 2001) Moreover, some of the highest densities of CB1 receptors have been found in regions of the human brain that…”
BackgroundInfluentialGone to Pot – A Review of the Association between Cannabis and Psychosis
Radhakrishnan, R., Wilkinson, S. T., & Dâ€TMSouza, D. C. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00054 · Cited by 327
Metadata
- Authors
- Leweke, F. M., Schneider, U., Thies, M., Münte, T. F., & Emrich, H. M.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Venue
- Psychopharmacology
- Published
- 1999-03-04
- Volume
- 142
- Issue
- 3
- Pages
- 230-235
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1972994864
- Cited by
- 102
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 5 · 2012: 3
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- delta-9-tetrahydrocannabinol, dronabinol, optical illusions, object familiarity, stereoscopic depth perception
- MeSH terms
- Adult, Electrophysiology, Hallucinogens, Humans, Illusions, Male, Middle Aged, Neuropsychology, Perception, Dronabinol, Vision, Binocular, Observation
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