The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Glycan labeling strategies and their use in identification and quantification
Open accessAbstract
Most methods for the analysis of oligosaccharides from biological sources require a glycan derivatization step: glycans may be derivatized to introduce a chromophore or fluorophore, facilitating detection after chromatographic or electrophoretic separation. Derivatization can also be applied to link charged or hydrophobic groups at the reducing end to enhance glycan separation and mass-spectrometric detection. Moreover, derivatization steps such as permethylation aim at stabilizing sialic acid residues, enhancing mass-spectrometric sensitivity, and supporting detailed structural characterization by (tandem) mass spectrometry. Finally, many glycan labels serve as a linker for oligosaccharide attachment to surfaces or carrier proteins, thereby allowing interaction studies with carbohydrate-binding proteins. In this review, various aspects of glycan labeling, separation, and detection strategies are discussed.
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Citations
Cites
Glycomic analysis by capillary electrophoresis–mass spectrometry
Mechref, Y., & Novotny, M. V. (2009) · Mass Spectrometry Reviews · doi:10.1002/mas.20196 · Cited by 105
Cited by
Mass spectrometry approaches to glycomic and glycoproteomic analyses
Ruhaak, L. R., Xu, G., Li, Q., Goonatilleke, E., & Lebrilla, C. B. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00732 · Cited by 395
Self-citationOligosaccharide Analysis by Mass Spectrometry: A Review of Recent Developments
Kailemia, M. J., Ruhaak, L. R., Lebrilla, C. B., & Amster, I. J. (2014) · Analytical Chemistry · doi:10.1021/ac403969n · Cited by 377
Self-citationHigh-sensitivity Analytical Approaches for the Structural Characterization of Glycoproteins
Alley, W. R., Mann, B. F., & Novotny, M. V. (2013) · Chemical Reviews · doi:10.1021/cr3003714 · Cited by 310
Lauber, M. A., Yu, Y.-Q., Brousmiche, D. W., Hua, Z., Koza, S. M., Magnelli, P., Guthrie, E., Taron, C. H., & Fountain, K. J. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00758 · Cited by 211
Glycan analysis of therapeutic glycoproteins
Zhang, L., Luo, S., & Zhang, B. (2016) · mAbs · doi:10.1080/19420862.2015.1117719 · Cited by 207
Metadata
- Authors
- Ruhaak, L. R., Zauner, G., Huhn, C., Bruggink, C., Deelder, A. M., & Wuhrer, M.
- Venue
- Analytical and Bioanalytical Chemistry
- Published
- 2010-03-12
- Volume
- 397
- Issue
- 8
- Pages
- 3457-3481
- ISSN
- 1618-2642 (ISSN-L)
- 1618-2650
- OpenAlex
- W2075166329
- Cited by
- 479
- References
- 1
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ruhaak, L. R., Zauner, G., Huhn, C., Bruggink, C., Deelder, A. M., & Wuhrer, M. (2010). Glycan labeling strategies and their use in identification and quantification. Analytical and Bioanalytical Chemistry. https://doi.org/10.1007/s00216-010-3532-z
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