The 2018 Nobel Prize in Chemistry: phage display of peptides and antibodies
Abstract
One-half of the 2018 Nobel Prize in Chemistry was awarded jointly to George P. Smith and Sir Gregory P. Winter "for the phage display of peptides and antibodies". This feature article summarizes significant achievements leading to the development of phage display of peptides and antibodies, where a bacteriophage is genetically modified to display peptides and proteins, with the primary aim of producing new biopharmaceuticals. These significant achievements are proven to be useful for the development of phage-based bioassays and biosensors.
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Directed evolution has been powerfully applied to developing and maturing monoclonal antibodies and was recognised as part of the 2018 Nobel Prize for Chemistry.
“This form of directed evolution has been powerfully applied to developing and maturing monoclonal antibodies and was recognised as part of the 2018 Nobel Prize for Chemistry (62).”
From Massively parallel functional genomic assays in endocrinology: from promise to delivery (2026) · cites this paper as [62]
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Advances in Ultrahigh Throughput Hit Discovery with Tandem Mass Spectrometry Encoded Libraries
Mata, J. M., van der Nol, E., & Pomplun, S. J. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c04899 · Cited by 27 · see citing works
Massively parallel functional genomic assays in endocrinology: from promise to delivery
Xu, J., Aslanzadeh, V., Kudla, G., & Semple, R. K. (2026) · Journal of Molecular Endocrinology · doi:10.1530/jme-25-0134
- Authors
- Barderas, R., & Benito-Peña, E.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Corresponding author
- Barderas, Rodrigo
- ORCID
- Barderas, Rodrigo
- Venue
- Analytical and Bioanalytical Chemistry
- Published
- 2019-03-19
- Volume
- 411
- Issue
- 12
- Pages
- 2475-2479
- ISSN
- 1618-2642 (ISSN-L)
- 1618-2650
- OpenAlex
- W2924815854
- Cited by
- 114
- References
- 0
- Citations by year
- 2026: 10 · 2025: 24 · 2024: 19 · 2023: 24 · 2022: 9 · 2021: 16 · 2020: 11 · 2019: 1
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Analytical and Bioanalytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III (PI17CIII/00045)
- Ministerio de Economía y Competitividad (CTQ2015-69278-C2)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- phage display, bacteriophages, peptide display, antibody display, biopharmaceuticals, biosensors
- MeSH terms
- Antibodies, Biopharmaceutics, Chemistry, Nobel Prize, Peptides, History, 21st Century, Cell Surface Display Techniques
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