Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study)
Open accessAbstract
In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people using data from a single axial computed tomographic section through the mid-thigh. Additionally, we studied the association of these variables with incident low-trauma lower limb fractures. A total of 3,762 older individuals (1,838 men and 1,924 women), aged 66-96 years, participants in the AGES-Reykjavik study, were studied. The total cross-sectional muscular area and knee extensor strength declined with age similarly in both sexes. Muscle parameters correlated most strongly with cortical area and total shaft area (adjusted for age, height, and weight) but explained <10 % of variability in those bone parameters. The increment in medullary area (MA) and buckling ratio (BR) with age was almost fourfold greater in women than men. The association between MA and muscle parameters was nonsignificant. During a median follow-up of 5.3 years, 113 women and 66 men sustained incident lower limb fractures. Small muscular area, low knee extensor strength, large MA, low cortical thickness, and high BR were significantly associated with fractures in both sexes. Our results show that bone and muscle loss proceed at different rates and with different gender patterns.
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In both the Health ABC and AGES studies, even when controlling for body composition, muscle attenuation was associated with increased risk of fracture.
“In both studies, even when controlling for body composition, the muscle attenuation was associated with increased risk of fracture (Lang et al., 2010; Johannesdottir et al., 2012; Frank-Wilson et al., 2018).”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Johannesdottir et al., 2012
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References 46 · Cited by 52
- Authors
- Johannesdottir, F., Aspelund, T., Siggeirsdottir, K., Jonsson, B. Y., Mogensen, B., Sigurdsson, S., Harris, T. B., Gudnason, V. G., Lang, T. F., & Sigurdsson, G.
- Affiliations
- University of Iceland (IS)
- Icelandic Heart Association (IS)
- National Institutes of Health (US)
- University of California, San Francisco (US)
- Corresponding author
- Sigurdsson, Gunnar
- Venue
- Calcified Tissue International
- Published
- 2012-03-27
- Volume
- 90
- Issue
- 5
- Pages
- 354-364
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- PMC
- PMC5111551
- OpenAlex
- W2070519681
- Cited by
- 52
- References
- 46
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 7 · 2013: 4 · 2012: 1
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Calcified Tissue International (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- Háskóli Íslands
- National Institutes of Health (n01ag12100-57-0-2)
- National Institute on Aging (N01-AG12100, N01-AG012100)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Surgery › Hip and Femur Fractures
- Keywords
- muscle mass, quadriceps strength, fragility fractures, lower limb fractures, older adults, sex differences, bone loss, muscle mass loss, buckling ratio, cortical thickness, AGES-Reykjavik Study
- MeSH terms
- Aged, Aged, 80 and over, Female, Femur, Follow-Up Studies, Humans, Male, Sex Factors, Cohort Studies, Bone Density, Muscle, Skeletal, Lower Extremity, Fractures, Bone
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