The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms
Open accessAbstract
Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly. Because the precise molecular mechanisms which are involved in the degradation of cartilage matrix and development of OA are poorly understood and there are currently no effective interventions to decelerate the progression of OA or retard the irreversible degradation of cartilage except for total joint replacement surgery. In this paper, the important molecular mechanisms related to OA pathogenesis will be summarized and new insights into potential molecular targets for the prevention and treatment of OA will be provided.
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1 retracted
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Developmental regulation of the growth plate
Kronenberg, H. M. (2003) · Nature · doi:10.1038/nature01657 · Cited by 2,849
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
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The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis
Wojdasiewicz, P., Poniatowski, Ł. A., & Szukiewicz, D. (2014) · Mediators of Inflammation · doi:10.1155/2014/561459 · Cited by 1,608
Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch
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Dickkopf-1 is a master regulator of joint remodeling
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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
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Cited by
Hu, Y., Gui, Z., Zhou, Y., Xia, L., Lin, K., & Xu, Y. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.09.024 · Cited by 292
Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity?
Meurot, C., Jacques, C., Martin, C., Sudre, L., Breton, J., Rattenbach, R., Bismuth, K., & Berenbaum, F. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.02.001 · Cited by 94
Metadata
- Authors
- Xia, B., Chen, D., Zhang, J., Hu, S., Jin, H., & Tong, P.
- Venue
- Calcified Tissue International
- Published
- 2014-10-14
- Volume
- 95
- Issue
- 6
- Pages
- 495-505
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- OpenAlex
- W2094371980
- Cited by
- 543
- References
- 139
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Xia, B., Chen, D., Zhang, J., Hu, S., Jin, H., & Tong, P. (2014). Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms. Calcified Tissue International. https://doi.org/10.1007/s00223-014-9917-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
