Biology of Bone Sarcomas and New Therapeutic Developments
Open accessAbstract
Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis. This review gives a brief overview of their specificities and summarises the main therapeutic advances in the field of bone sarcoma.
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Osteosarcoma is slightly more common in males, with an average male-to-female ratio of 1.4:1.
“Osteosarcoma is slightly more common in males, with an average male-to-female ratio of 1.4:1 (ref.15 ).”
From Osteosarcoma (2022) · cites this paper as [15]
The seed and soil phenomenon in osteosarcoma is driven by a microenvironment that modulates osteosarcoma cell behaviour and facilitates proliferation, quiescence, invasion, migration and drug resistance, and contributes to intrinsic heterogeneity.
“This seed and soil phenomenon is driven by a microenvironment that modulates osteosarcoma cell behaviour and facilitates proliferation, quiescence, invasion, migration, and drug resistance 15,51,52,53 and contributes to their intrinsic heterogeneity 54,55 .”
From Osteosarcoma (2022) · cites this paper as [15]
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References 147 · Cited by 163
Research works printed but not linked: 2
- [3]Heymann D Bone cancer: primary bone cancer an bone metastases 2014 2 San Diego Elsevier
- [45]Bovée JV Hogendoorn PC Wunder JS Alman BA Cartilage tumours and bone development: molecular pathology and possible therapeutic targets Nat Rev Cancer 2010 10 481 488 10.1038/nrc2869 20535132 · DOI
- Authors
- Brown, H. K., Schiavone, K., Gouin, F., Heymann, M.-F., & Heymann, D.
- Affiliations
- Inserm (FR)
- Corresponding author
- Heymann, Dominique
- Venue
- Calcified Tissue International
- Published
- 2017-12-13
- Volume
- 102
- Issue
- 2
- Pages
- 174-195
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- PMC
- PMC5805807
- OpenAlex
- W2773926595
- Cited by
- 163
- References
- 147
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 20 · 2023: 30 · 2022: 17 · 2021: 25 · 2020: 19 · 2019: 17 · 2018: 8
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Calcified Tissue International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- HAL (submittedVersion, cc-by)
- HAL (submittedVersion, other-oa)
- Funders
- Bone Cancer Research Trust (144681)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Veterinary Oncology Research
- Keywords
- bone sarcoma, osteosarcoma, Ewing sarcoma, chondrosarcoma, mesenchymal tumors, tumor heterogeneity, tumor microenvironment, pathogenesis, cancer therapy, childhood cancer
- MeSH terms
- Bone Neoplasms, Female, Humans, Male, Sarcoma, Giant Cell Tumor of Bone, Tumor Microenvironment
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