Multi-Tiered Analysis of Brain Injury in Neonates With Congenital Heart Disease
Open accessAbstract
Early brain injury occurs in newborns with congenital heart disease (CHD) placing them at risk for impaired neurodevelopmental outcomes. Predictors for preoperative brain injury have not been well described in CHD newborns. This study aimed to analyze, retrospectively, brain magnetic resonance imaging (MRI) in a heterogeneous group of newborns who had CHD surgery during the first month of life using a detailed qualitative CHD MRI Injury Score, quantitative imaging assessments (regional apparent diffusion coefficient [ADC] values and brain volumes), and clinical characteristics. Seventy-three newborns who had CHD surgery at 8 ± 5 (mean ± SD) days of life and preoperative brain MRI were included; 38 also had postoperative MRI. Thirty-four (34 of 73, 47 %) had at least one type of preoperative brain injury, and 28 of 38 (74 %) had postoperative brain injury. The 5-min APGAR score was negatively associated with preoperative injury, but there was no difference between CHD types. Infants with intraparenchymal hemorrhage, deep gray matter injury, and/or watershed infarcts had the highest CHD MRI Injury Scores. ADC values and brain volumes were not different in infants with different CHD types or in those with and without brain injury. In a mixed group of CHD newborns, brain injury was found preoperatively on MRI in almost 50 %, and there were no significant baseline characteristic differences to predict this early brain injury except 5-min APGAR score. We conclude that all infants, regardless of CHD type, who require early surgery should be evaluated with MRI because they are all at high risk for brain injury.
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Patients with single ventricle pathology have longer postoperative stay, more additional operations, and more frequent cardiopulmonary resuscitation and extracorporeal membrane oxygenation than patients with transposition of the great arteries, but incidences of acquired brain injury are similar between the two groups.
“Patients with SVP show longer length of postoperative stay, more additional operations, more often cardiopulmonary resuscitation and extracorporal membrane oxygenation than patients with TGA, 82 but incidences of acquired brain injury are similar between the two groups.59,83”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [83]
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References 42 · Cited by 34
- Authors
- Mulkey, S. B., Swearingen, C. J., Melguizo, M. S., Schmitz, M. L., Ou, X., Ramakrishnaiah, R. H., Glasier, C. M., Bradley Schaefer, G., & Bhutta, A. T.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- Corresponding author
- Mulkey, Sarah B.
- ORCID
- Venue
- Pediatric Cardiology
- Published
- 2013-05-08
- Volume
- 34
- Issue
- 8
- Pages
- 1772-1784
- ISSN
- 0172-0643 (ISSN-L)
- 1432-1971
- PMC
- PMC3973037
- OpenAlex
- W2028238552
- Cited by
- 34
- References
- 42
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 2
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pediatric Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Arkansas
- University of Arkansas for Medical Sciences
- National Institutes of Health
- Institute for Translational Neuroscience
- National Institute of General Medical Sciences (P20GM103425, P30GM110702)
- National Center for Research Resources (UL1RR029884)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Keywords
- congenital heart disease, neonatal brain injury, apparent diffusion coefficient, brain volume, Apgar score, intraparenchymal hemorrhage, watershed infarction, neurodevelopmental outcomes, neonatal cardiac surgery
- MeSH terms
- Arkansas, Brain, Brain Diseases, Follow-Up Studies, Heart Defects, Congenital, Cardiac Surgical Procedures, Humans, Infant, Newborn, Magnetic Resonance Imaging, Prognosis, Retrospective Studies, Risk Factors, Severity of Illness Index, Time Factors, Prevalence
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