Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives
Open accessAbstract
The growing awareness of the importance of chirality in conjunction with biological activity has led to an increasing demand for efficient methods for the industrial synthesis of enantiomerically pure compounds. Polyhydroxyalkanotes (PHAs) are a family of polyesters consisting of over 140 chiral R-hydroxycarboxylic acids (R-HAs), representing a promising source for obtaining chiral chemicals from renewable carbon sources. Although some R-HAs have been produced for some time and certain knowledge of the production processes has been gained, large-scale production has not yet been possible. In this article, through analysis of the current advances in production of these acids, we present guidelines for future developments in biotechnological processes for R-HA production.
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Biological catalysis offers advantages over chemical synthesis, such as stereo-selective production of chemical compounds.
“Moreover, biological catalysis offers several advantages over chemical synthesis, such as stereo-selective production of chemical compounds [9].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [9]
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References 148 · Cited by 113
Research works printed but not linked: 2
- Ohashi T Hasegawa J Collins AN Sheldrake GN Crosby J D-(−)-β-hydroxycarboxylic acids as raw materials for captopril and beta lactams Chirality in Industry 1992 New York John Wiley & Sons Ltd 269 278
- Ohashi T Hasegawa J Collins AN Sheldrake G Crosby J New preparative methods for optically active β-hydroxycarboxylic acids Chirality in Industry 1992 New York John Wiley & Sons 249 268
- Authors
- Ren, Q., Ruth, K., Thöny-Meyer, L., & Zinn, M.
- Affiliations
- Empa (CH)
- Corresponding author
- Ren, Qun
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2010-04-15
- Volume
- 87
- Issue
- 1
- Pages
- 41-52
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- PMC
- PMC2872024
- OpenAlex
- W2026370090
- Cited by
- 113
- References
- 148
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 13 · 2019: 12 · 2018: 6 · 2017: 11 · 2016: 4 · 2015: 13 · 2014: 7 · 2013: 9 · 2012: 4
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Applied Microbiology and Biotechnology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) (submittedVersion, other-oa)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, other-oa)
- ETH Zürich Research Collection
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- polyhydroxyalkanoates, enantiomerically pure compounds, renewable carbon sources, biotechnological production, industrial-scale production, biopolymer production
- MeSH terms
- Bacteria, Biotechnology, Carboxylic Acids, Polyesters, Stereoisomerism
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