Regulation of immunity and oncogenesis by the IRF transcription factor family
Open accessAbstract
Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis.
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STAT1 and IRF5 are involved in M1 polarization/maintenance; STAT6, IRF4, CREB-C/EBPβ, and PPARγ are involved in M2 polarization/maintenance.
“Specifically, STAT1 and IRF5 have been shown to be involved in polarization and maintenance of an M1 phenotype while STAT6, IRF4, CREB-C/EBPβ, and PPARγ are involved in polarization and maintenance of an M2 phenotype [23–30].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [30]
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- Authors
- Savitsky, D., Tamura, T., Yanai, H., & Taniguchi, T.
- Affiliations
- The University of Tokyo (JP)
- Corresponding author
- Taniguchi, Tadatsugu
- Venue
- Cancer Immunology, Immunotherapy
- Published
- 2010-01-05
- Volume
- 59
- Issue
- 4
- Pages
- 489-510
- ISSN
- 0340-7004 (ISSN-L)
- 1432-0851
- PMC
- PMC11030943
- OpenAlex
- W1978990512
- Cited by
- 298
- References
- 228
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 15 · 2023: 20 · 2022: 14 · 2021: 21 · 2020: 11 · 2019: 25 · 2018: 12 · 2017: 21 · 2016: 22 · 2015: 23 · 2014: 22 · 2013: 24 · 2012: 22
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Cancer Immunology Immunotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- University of Pittsburgh
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- interferon regulatory factors, IRF transcription factors, type I interferon, immune regulation, carcinogenesis, host defense, immune cell development, tumor immunology
- MeSH terms
- Animals, Humans, Immunity, Neoplasms, Interferon Regulatory Factors
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