Increased risk of zoonotic Salmonella and Campylobacter gastroenteritis in patients with haematological malignancies: a population-based study
Open accessAbstract
We hypothesised that haematological malignancies increase the risk of acquiring zoonotic Salmonella or Campylobacter gastroenteritis. The population-based study comprised all first-time Salmonella/Campylobacter gastroenteritis cases in two Danish counties (1991-2003), with age- and gender-matched controls from the background population. We linked the study cohort to registries to obtain data on malignancies, chemotherapy (yes/no), and main comorbidities diagnosed before Salmonella/Campylobacter gastroenteritis. Based on this design, we determined incidence rate ratios (IRR) in conditional logistic regression analyses, and we used weighted mean regression curves to evaluate fluctuations in risk 0-5 years after the malignancy diagnosis. Sixty-eight of 13,324 cases (0.5%) and 29 of 26,648 controls (0.1%) had haematological malignancy before their Salmonella/Campylobacter gastroenteritis. Comorbidity-adjusted IRR for Salmonella/Campylobacter gastroenteritis in patients with haematological malignancy as compared to patients without malignancy were 4.46 [95% confidence intervals (CI), 2.88-6.90] for all individuals, 8.33 (95% CI, 4.31-16.1) for Salmonella, and 2.17 (95% CI, 1.15-4.08) for Campylobacter. Stratification on chemotherapy treatment did not change these estimates. In time-related analyses, IRR were 7-8 in the first 2 years after the haematological malignancy diagnosis and 4-5 in the following 3 years. Patients with haematological malignancy had increased long-term risk o…
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Young children (age < 5 years), older adults (age >= 65 years), immunocompromised patients, and pregnant women are at increased risk for zoonotic diseases from pets.
“Pets are a potential source of infection, with patients who are immunocompromised, pregnant women, young children and older adults at the greatest risk for transmission.”
From Reducing the risk of pet-associated zoonotic infections (2015) · cites this paper as [14]
High-risk groups may have more severe disease, longer symptom duration, or more severe complications than other patients.
“may have more severe disease, may have symptoms for a longer duration, or may have more severe complications than other patients. 13-15”
From Reducing the risk of pet-associated zoonotic infections (2015) · cites this paper as [14]
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Reducing the risk of pet-associated zoonotic infections
Stull, J. W., Brophy, J., & Weese, J. S. (2015) · Canadian Medical Association Journal · doi:10.1503/cmaj.141020 · Cited by 164 · see citing works
- Authors
- Gradel, K. O., Nørgaard, M., Dethlefsen, C., Schønheyder, H. C., Kristensen, B., Ejlertsen, T., & Nielsen, H.
- Affiliations
- Aalborg University Hospital (DK)
- Aarhus University Hospital (DK)
- Corresponding author
- Gradel, Kim O.
- ORCID
- Venue
- Annals of Hematology
- Published
- 2008-12-16
- Volume
- 88
- Issue
- 8
- Pages
- 761-767
- ISSN
- 0939-5555 (ISSN-L)
- 1432-0584
- OpenAlex
- W2001148407
- Cited by
- 31
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 6 · 2012: 2
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Annals of Hematology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Keywords
- Salmonella gastroenteritis, Campylobacter gastroenteritis, hematologic malignancies, infection risk, chemotherapy, comorbidities, incidence rate ratio
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Antineoplastic Agents, Campylobacter Infections, Child, Child, Preschool, Denmark, Disease Susceptibility, Female, Gastroenteritis, Humans, Infant, Infant, Newborn, Male, Middle Aged, Opportunistic Infections, Registries, Regression, Psychology, Risk, Salmonella Infections, Zoonoses, Incidence, Case-Control Studies, Hematologic Neoplasms, Young Adult
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