The feto–maternal interface: setting the stage for potential immune interactions
Abstract
Human implantation and placentation comprise the direct contact of fetal with maternal tissues culminating in the erosion of maternal tissues by fetal cells. A complex interplay of maternal and fetal factors is key to maintain pregnancy until delivery. Immunological interactions can be found at different stages, such as blastocyst attachment, trophoblast invasion into maternal tissues, and flow of maternal blood through the placenta. These interactions need tightly controlled mechanisms to avoid rejection of the conceptus. In this study, these sites of interaction are introduced on a morphological level to help immunologists create their hypotheses on how the immunological interactions may work.
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References 98 · Cited by 52
- Authors
- Huppertz, B.
- Affiliations
- Medical University of Graz (AT)
- Corresponding author
- Huppertz, Berthold
- ORCID
- Huppertz, Berthold
- Venue
- Seminars in Immunopathology
- Published
- 2007-04-13
- Volume
- 29
- Issue
- 2
- Pages
- 83-94
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- OpenAlex
- W1996166328
- Cited by
- 52
- References
- 98
- Citations by year
- 2025: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 5
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Immunopathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Keywords
- maternal-fetal interface, pregnancy immunology, implantation, placentation, trophoblast invasion, blastocyst attachment, maternal-fetal immune interaction, maternal-fetal immune tolerance, placental blood flow
- MeSH terms
- Blastocyst, Female, Gestational Age, Humans, Maternal-Fetal Exchange, Embryo Implantation, Placenta, Placentation, Pregnancy, Pregnancy Complications, Trophoblasts
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