The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Biocompatibility of implants: lymphocyte/macrophage interactions
Abstract
The monocyte-derived macrophage is recognized as a critical determinant in biocompatibility, but its appearance in the chronic inflammatory phase is accompanied by the presence of lymphocytes, which have been much less studied in this regard. Here, we first present an overview of the physiologic continuum comprising host reactions to the surgical implantation of biomaterial. Secondly, we describe our collective research efforts, which indicate that lymphocytes are additional and key cellular determinants of biocompatible outcome. Thus, bioengineering advances will require that lymphocyte responses be regarded as integral components of innate inflammatory and immune/immunotoxic cell interactions at sites of biomaterial implantation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Likewise, Th2 lymphocyte derived signals such as IL-4 and IL-13 direct M2 polarization of macrophages that in turn produce chemokines such as CCL17, CCL22 and CCL24, which enhance the recruitment of Th2 lymphocytes [68].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [68]
In the citing paper
“In addition to the well-established role of macrophages in response to implanted biomaterials, emerging research suggests that lymphocytes are key cellular determinants of biomaterial outcomes [68].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [68]
In the citing paper
“TH1 lymphocytes release IFN-g which polarizes cells toward an M1 phenotype, secreting several pro-inflammatory cytokines and chemokines, some of which (IL-12, CXCL-10) escalate the inflammatory response by recruiting more Th1 lymphocytes [68,69].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [68]
Citations
Cites
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Biomaterials Science: An Introduction to Materials in Medicine
Ratner, B. D., Hoffman, A. S., Schöen, F. J., & Lemons, J. E. (1996) · doi:10.1016/c2009-0-02433-7 · Cited by 5,125
Giancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869
RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS
Ruoslahti, E. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.697 · Cited by 3,191
Pathology of Drug-Eluting Stents in Humans
Joner, M., Finn, A. V., Farb, A. A., Mont, E. K., Kolodgie, F. D., Ladich, E. R., Kutys, R., Skorija, K., Gold, H. K., & Virmani, R. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.03.042 · Cited by 2,751
Inflammation. Basic principles and clinical correlates
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90156-x · Cited by 2,388
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960
Vitamin E: function and metabolism
Brigelius‐Flohé, R., & Traber, M. G. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.10.1145 · Cited by 1,592
Biological Responses to Materials
Anderson, J. M. (2001) · Annual Review of Materials Research · doi:10.1146/annurev.matsci.31.1.81 · Cited by 1,465
Self-citation
Research works printed but not linked: 4
- Anderson JM, Schoen FJ, Brown SA, Merritt K (2004) Chapter 9.5. Implant retrieval and evaluation. In: Ratner BD, As Hoffman, Schoen FJ, Lemons JE (eds) Biomaterials science: an introduction to materials in medicine. Elsevier, New York, pp 771–782
- Anderson JM (2004) Chapter 4.2. Inflammation, wound healing, and the foreign body response. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) Biomaterials science: an introduction to materials in medicine. Elsevier, New York, pp 296–304
- Keegan AD (2001) IL-4. In: Oppenheim JJ, Feldman M (eds) Cytokine reference. Academic, San Diego
- McKenzie ANJ, Matthews DJ (2001) IL-13. In: Oppenheim JJ, Feldman M (eds) Cytokine reference. Academic, San Diego
Cited by
Sorted by citations
Vascular Endothelial Cell Biology: An Update
Krüger‐Genge, A., Blocki, A. M., Franke, R., & Jung, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184411 · Cited by 1,249
Advances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 890
Biomaterial based modulation of macrophage polarization: a review and suggested design principles
Sridharan, R., Cameron, A. R., Kelly, D. J., Kearney, C. J., & O’Brien, F. J. (2015) · Materials Today · doi:10.1016/j.mattod.2015.01.019 · Cited by 826
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Mariani, E., Lisignoli, G., Borzì, R. M., & Pulsatelli, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030636 · Cited by 706
Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response
Vishwakarma, A., Bhise, N. S., Evangelista, M. B., Rouwkema, J., Dokmeci, M. R., Ghaemmaghami, A. M., Vrana, N. E., & Khademhosseini, A. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.03.009 · Cited by 516
Metadata
- Authors
- Anderson, J. M., & McNally, A. K.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Anderson, James M.
- ORCID
- Anderson, James M.
- Venue
- Seminars in Immunopathology
- Published
- 2011-01-27
- Volume
- 33
- Issue
- 3
- Pages
- 221-233
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- OpenAlex
- W2036077057
- Cited by
- 226
- References
- 109
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 17 · 2022: 16 · 2021: 19 · 2020: 34 · 2019: 18 · 2018: 14 · 2017: 13 · 2016: 18 · 2015: 22 · 2014: 13 · 2013: 10 · 2012: 14
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Seminars in Immunopathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (EB 00282)
- Topics
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Keywords
- implant biocompatibility, lymphocytes, macrophages, monocyte-derived macrophages, biomaterial implantation, host immune response, chronic inflammation, immunotoxicity, innate immunity, macrophage-lymphocyte interaction
- MeSH terms
- Animals, Biocompatible Materials, Cell Communication, Humans, Inflammation, Lymphocytes, Macrophages, Wound Healing, Prostheses and Implants
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
