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Cited by 165

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Immunopathogenesis of Staphylococcus aureus pulmonary infection

Open access
Parker, Dane, Prince, Alice·2012·Seminars in Immunopathology

Abstract

Staphylococcus aureus is a common human pathogen highly evolved as both a component of the commensal flora and as a major cause of invasive infection. Severe respiratory infection due to staphylococci has been increasing due to the prevalence of more virulent USA300 CA-MRSA strains in the general population. The ability of S. aureus to adapt to the milieu of the respiratory tract has facilitated its emergence as a respiratory pathogen. Its metabolic versatility, the ability to scavenge iron, coordinate gene expression, and the horizontal acquisition of useful genetic elements have all contributed to its success as a component of the respiratory flora, in hospitalized patients, as a complication of influenza and in normal hosts. The expression of surface adhesins facilitates its persistence in the airways. In addition, the highly sophisticated interactions of the multiple S. aureus virulence factors, particularly the α-hemolysin and protein A, with diverse immune effectors in the lung such as ADAM10, TNFR1, EGFR, immunoglobulin, and complement all contribute to the pathogenesis of staphylococcal pneumonia.

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Metadata

Authors
Parker, D., & Prince, A.
Venue
Seminars in Immunopathology
Published
2011-10-31
Volume
34
Issue
2
Pages
281-297
ISSN
  • 1863-2297 (ISSN-L)
  • 1863-2300
OpenAlex
W2005388425
Cited by
165
References
31
FWCI
5.41
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Immunopathogenesis of Staphylococcus aureus pulmonary infection. https://app.cochat.ai/papers/10.1007/s00281-011-0291-7
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Parker, D., & Prince, A. (2012). Immunopathogenesis of Staphylococcus aureus pulmonary infection. Seminars in Immunopathology. https://doi.org/10.1007/s00281-011-0291-7

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.