Potential importance of B cells in aging and aging-associated neurodegenerative diseases
Open accessAbstract
Our understanding of B cells as merely antibody producers is slowly changing. Alone or in concert with antibody, they control outcomes of seemingly different diseases such as cancer, rheumatoid arthritis, diabetes, and multiple sclerosis. While their role in activation of effector immune cells is beneficial in cancer but bad in autoimmune diseases, their immunosuppressive and regulatory subsets (Bregs) inhibit autoimmune and anticancer responses. These pathogenic and suppressive functions are not static and appear to be regulated by the nature and strength of inflammation. Although aging increases inflammation and changes the composition and function of B cells, surprisingly, little is known whether the change affects aging-associated neurodegenerative disease, such as Alzheimer's disease (AD). Here, by analyzing B cells in cancer and autoimmune and neuroinflammatory diseases, we elucidate their potential importance in AD and other aging-associated neuroinflammatory diseases.
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Functional immune cells can enter the CNS through the blood-brain barrier, choroid plexus, and lymphatic vessels and have been described beyond neuropathological conditions.
“However, the idea that the CNS is an immune privileged organ has been reconsidered, as the functional immune cells can enter the CNS through the BBB, the choroid plexus, and the lymphatic vessels and have been described beyond neuropathological conditions (26, 35–47).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [37]
Bacterial products and metabolites can pass the blood-brain barrier and shape CNS development and functions and the genesis of certain diseases.
“Among the molecules that can pass the BBB are also bacterial products and metabolites shaping not only the CNS development and functions (6, 15) but also the genesis of certain diseases (33–42).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [37]
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References 227 · Cited by 25
- Authors
- Biragyn, A., Aliseychik, M., & Rogaev, E.
- Affiliations
- National Institute on Aging (US)
- University of Massachusetts Chan Medical School (US)
- Russian Academy of Sciences (RU)
- Corresponding author
- Biragyn, Arya
- Venue
- Seminars in Immunopathology
- Published
- 2017-01-12
- Volume
- 39
- Issue
- 3
- Pages
- 283-294
- ISSN
- 1863-2297 (ISSN-L)
- 1863-2300
- PMC
- PMC8011659
- OpenAlex
- W2572872292
- Cited by
- 25
- References
- 227
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2018: 2 · 2017: 2
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-01-14)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Immunopathology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (ZIAAG000778)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- B cells, regulatory B cells, aging, neurodegenerative diseases, Alzheimer's disease, neuroinflammation, autoimmune disease, tumor immunology, immunosuppression, inflammation
- MeSH terms
- Aging, Alzheimer Disease, Animals, B-Lymphocytes, Humans, Immunoglobulins, Inflammation, Neurodegenerative Diseases
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